9LQ1

Structure of human DNMT3A-TCL1A complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000775	cellular_component	chromosome, centromeric region
A	0000791	cellular_component	euchromatin
A	0000792	cellular_component	heterochromatin
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0001741	cellular_component	XY body
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003714	molecular_function	transcription corepressor activity
A	0003886	molecular_function	DNA (cytosine-5-)-methyltransferase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0006325	biological_process	chromatin organization
A	0006346	biological_process	DNA methylation-dependent constitutive heterochromatin formation
A	0008168	molecular_function	methyltransferase activity
A	0008270	molecular_function	zinc ion binding
A	0009410	biological_process	response to xenobiotic stimulus
A	0009636	biological_process	response to toxic substance
A	0010212	biological_process	response to ionizing radiation
A	0010288	biological_process	response to lead ion
A	0016363	cellular_component	nuclear matrix
A	0016740	molecular_function	transferase activity
A	0030182	biological_process	neuron differentiation
A	0031048	biological_process	regulatory ncRNA-mediated heterochromatin formation
A	0031667	biological_process	response to nutrient levels
A	0032259	biological_process	methylation
A	0032355	biological_process	response to estradiol
A	0033189	biological_process	response to vitamin A
A	0042220	biological_process	response to cocaine
A	0044027	biological_process	negative regulation of gene expression via chromosomal CpG island methylation
A	0045322	molecular_function	unmethylated CpG binding
A	0045471	biological_process	response to ethanol
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046872	molecular_function	metal ion binding
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0071361	biological_process	cellular response to ethanol
A	0071456	biological_process	cellular response to hypoxia
A	0097284	biological_process	hepatocyte apoptotic process
A	0106222	molecular_function	lncRNA binding
A	0106363	molecular_function	protein-cysteine methyltransferase activity
A	0141196	biological_process	transposable element silencing by piRNA-mediated DNA methylation
A	1900039	biological_process	positive regulation of cellular response to hypoxia
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0019901	molecular_function	protein kinase binding
B	0035556	biological_process	intracellular signal transduction
B	0042802	molecular_function	identical protein binding
B	0043539	molecular_function	protein serine/threonine kinase activator activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005829	cellular_component	cytosol
C	0019901	molecular_function	protein kinase binding
C	0035556	biological_process	intracellular signal transduction
C	0042802	molecular_function	identical protein binding
C	0043539	molecular_function	protein serine/threonine kinase activator activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005829	cellular_component	cytosol
D	0019901	molecular_function	protein kinase binding
D	0035556	biological_process	intracellular signal transduction
D	0042802	molecular_function	identical protein binding
D	0043539	molecular_function	protein serine/threonine kinase activator activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005829	cellular_component	cytosol
E	0019901	molecular_function	protein kinase binding
E	0035556	biological_process	intracellular signal transduction
E	0042802	molecular_function	identical protein binding
E	0043539	molecular_function	protein serine/threonine kinase activator activity
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000775	cellular_component	chromosome, centromeric region
F	0000791	cellular_component	euchromatin
F	0000792	cellular_component	heterochromatin
F	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
F	0001741	cellular_component	XY body
F	0003677	molecular_function	DNA binding
F	0003682	molecular_function	chromatin binding
F	0003714	molecular_function	transcription corepressor activity
F	0003886	molecular_function	DNA (cytosine-5-)-methyltransferase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0005737	cellular_component	cytoplasm
F	0006325	biological_process	chromatin organization
F	0006346	biological_process	DNA methylation-dependent constitutive heterochromatin formation
F	0008168	molecular_function	methyltransferase activity
F	0008270	molecular_function	zinc ion binding
F	0009410	biological_process	response to xenobiotic stimulus
F	0009636	biological_process	response to toxic substance
F	0010212	biological_process	response to ionizing radiation
F	0010288	biological_process	response to lead ion
F	0016363	cellular_component	nuclear matrix
F	0016740	molecular_function	transferase activity
F	0030182	biological_process	neuron differentiation
F	0031048	biological_process	regulatory ncRNA-mediated heterochromatin formation
F	0031667	biological_process	response to nutrient levels
F	0032259	biological_process	methylation
F	0032355	biological_process	response to estradiol
F	0033189	biological_process	response to vitamin A
F	0042220	biological_process	response to cocaine
F	0044027	biological_process	negative regulation of gene expression via chromosomal CpG island methylation
F	0045322	molecular_function	unmethylated CpG binding
F	0045471	biological_process	response to ethanol
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0046872	molecular_function	metal ion binding
F	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
F	0071361	biological_process	cellular response to ethanol
F	0071456	biological_process	cellular response to hypoxia
F	0097284	biological_process	hepatocyte apoptotic process
F	0106222	molecular_function	lncRNA binding
F	0106363	molecular_function	protein-cysteine methyltransferase activity
F	0141196	biological_process	transposable element silencing by piRNA-mediated DNA methylation
F	1900039	biological_process	positive regulation of cellular response to hypoxia

Functional Information from PROSITE/UniProt

site_id	PS00094
Number of Residues	13
Details	C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. DlVigGsPCnDLS

Chain	Residue	Details
A	ASP702-SER714

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	264
Details	Domain: {"description":"ADD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00865","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	556
Details	Domain: {"description":"SAM-dependent MTase C5-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01016","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	60
Details	Zinc finger: {"description":"GATA-type; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00865","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	112
Details	Zinc finger: {"description":"PHD-type; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00865","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	184
Details	Region: {"description":"Interaction with the PRC2/EED-EZH2 complex","evidences":[{"source":"UniProtKB","id":"O88508","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01016","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10018","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17713477","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QRV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"S-methylcysteine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"O88508","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---