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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9LOL

Cryo-EM structure of human MON1A-CCZ1-RAB7A

Functional Information from GO Data
ChainGOidnamespacecontents
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005765cellular_componentlysosomal membrane
A0007034biological_processvacuolar transport
A0016192biological_processvesicle-mediated transport
A0035658cellular_componentMon1-Ccz1 complex
C0000045biological_processautophagosome assembly
C0000166molecular_functionnucleotide binding
C0000421cellular_componentautophagosome membrane
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005739cellular_componentmitochondrion
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005770cellular_componentlate endosome
C0005811cellular_componentlipid droplet
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006622biological_processprotein targeting to lysosome
C0006629biological_processlipid metabolic process
C0006897biological_processendocytosis
C0006914biological_processautophagy
C0007174biological_processepidermal growth factor catabolic process
C0008333biological_processendosome to lysosome transport
C0009617biological_processresponse to bacterium
C0010008cellular_componentendosome membrane
C0015031biological_processprotein transport
C0016042biological_processlipid catabolic process
C0016787molecular_functionhydrolase activity
C0019003molecular_functionGDP binding
C0019076biological_processviral release from host cell
C0022615biological_processprotein to membrane docking
C0030667cellular_componentsecretory granule membrane
C0030670cellular_componentphagocytic vesicle membrane
C0030672cellular_componentsynaptic vesicle membrane
C0030904cellular_componentretromer complex
C0031267molecular_functionsmall GTPase binding
C0031410cellular_componentcytoplasmic vesicle
C0031902cellular_componentlate endosome membrane
C0031966cellular_componentmitochondrial membrane
C0032935molecular_functionsterol sensor activity
C0032991cellular_componentprotein-containing complex
C0033162cellular_componentmelanosome membrane
C0034045cellular_componentphagophore assembly site membrane
C0036466biological_processsynaptic vesicle recycling via endosome
C0042147biological_processretrograde transport, endosome to Golgi
C0042632biological_processcholesterol homeostasis
C0045022biological_processearly endosome to late endosome transport
C0045335cellular_componentphagocytic vesicle
C0045453biological_processbone resorption
C0045732biological_processpositive regulation of protein catabolic process
C0048524biological_processpositive regulation of viral process
C0061462biological_processprotein localization to lysosome
C0061724biological_processlipophagy
C0070062cellular_componentextracellular exosome
C0090120biological_processlysosome to ER cholesterol transport
C0090382biological_processphagosome maturation
C0090383biological_processphagosome acidification
C0090385biological_processphagosome-lysosome fusion
C0097208cellular_componentalveolar lamellar body
C0098588cellular_componentbounding membrane of organelle
C0098830cellular_componentpresynaptic endosome
C0099638biological_processendosome to plasma membrane protein transport
C1903542biological_processnegative regulation of exosomal secretion
C1903543biological_processpositive regulation of exosomal secretion
C1905366biological_processnegative regulation of intralumenal vesicle formation
C1905394molecular_functionretromer complex binding
Functional Information from PROSITE/UniProt
site_idPS00675
Number of Residues14
DetailsSIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VIIlGDSGVGKtsL
ChainResidueDetails
CVAL11-LEU24
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues13
DetailsMotif: {"description":"Switch 1","evidences":[{"source":"PubMed","id":"15933719","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T91","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YHN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues15
DetailsMotif: {"description":"Switch 2","evidences":[{"source":"PubMed","id":"15933719","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T91","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YHN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20028791","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3LAW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15933719","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20028791","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1T91","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LAW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15933719","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20028791","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T91","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LAW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15933719","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YHN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15933719","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20028791","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LAW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by LRRK1","evidences":[{"source":"PubMed","id":"36040231","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

248942

PDB entries from 2026-02-11

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