9LLZ
Cryo-EM structure of a class C GPCR (Global, without symmetry)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0001640 | molecular_function | adenylate cyclase inhibiting G protein-coupled glutamate receptor activity |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007196 | biological_process | adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway |
| A | 0007216 | biological_process | G protein-coupled glutamate receptor signaling pathway |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0007626 | biological_process | locomotory behavior |
| A | 0008066 | molecular_function | glutamate receptor activity |
| A | 0009584 | biological_process | detection of visible light |
| A | 0030425 | cellular_component | dendrite |
| A | 0035841 | cellular_component | new growing cell tip |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0045202 | cellular_component | synapse |
| A | 0050908 | biological_process | detection of light stimulus involved in visual perception |
| A | 0050953 | biological_process | sensory perception of light stimulus |
| A | 0051286 | cellular_component | cell tip |
| A | 0051966 | biological_process | regulation of synaptic transmission, glutamatergic |
| A | 1905665 | biological_process | positive regulation of calcium ion import across plasma membrane |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0001640 | molecular_function | adenylate cyclase inhibiting G protein-coupled glutamate receptor activity |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007196 | biological_process | adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway |
| B | 0007216 | biological_process | G protein-coupled glutamate receptor signaling pathway |
| B | 0007268 | biological_process | chemical synaptic transmission |
| B | 0007626 | biological_process | locomotory behavior |
| B | 0008066 | molecular_function | glutamate receptor activity |
| B | 0009584 | biological_process | detection of visible light |
| B | 0030425 | cellular_component | dendrite |
| B | 0035841 | cellular_component | new growing cell tip |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0045202 | cellular_component | synapse |
| B | 0050908 | biological_process | detection of light stimulus involved in visual perception |
| B | 0050953 | biological_process | sensory perception of light stimulus |
| B | 0051286 | cellular_component | cell tip |
| B | 0051966 | biological_process | regulation of synaptic transmission, glutamatergic |
| B | 1905665 | biological_process | positive regulation of calcium ion import across plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00041 |
| Number of Residues | 43 |
| Details | HTH_ARAC_FAMILY_1 Bacterial regulatory proteins, araC family signature. RVvaVVgaSassvsim..VaNVLRLfAIpqis.YastAPElsDsTR |
| Chain | Residue | Details |
| B | ARG144-ARG186 |
| site_id | PS00979 |
| Number of Residues | 19 |
| Details | G_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNVLrLFaIPQISyASTA |
| Chain | Residue | Details |
| B | VAL160-ALA178 |
| site_id | PS00980 |
| Number of Residues | 23 |
| Details | G_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCWhCeaCdgyrFqv...DefTCeaC |
| Chain | Residue | Details |
| B | CYS536-CYS558 |
| site_id | PS00981 |
| Number of Residues | 11 |
| Details | G_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKpIGFTM |
| Chain | Residue | Details |
| B | PHE779-MET789 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 50 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 102 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
