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9LHP

Crystal structure of human thymine DNA glycosylase TDG in complex with a covalent inhibitor (1S, 5R)-C-2711

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005643cellular_componentnuclear pore
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006281biological_processDNA repair
B0015459molecular_functionpotassium channel regulator activity
B0016604cellular_componentnuclear body
B0016605cellular_componentPML body
B0016607cellular_componentnuclear speck
B0016925biological_processprotein sumoylation
B0019899molecular_functionenzyme binding
B0031334biological_processpositive regulation of protein-containing complex assembly
B0031386molecular_functionprotein tag activity
B0031625molecular_functionubiquitin protein ligase binding
B0031647biological_processregulation of protein stability
B0031965cellular_componentnuclear membrane
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0034605biological_processcellular response to heat
B0042308biological_processnegative regulation of protein import into nucleus
B0044388molecular_functionsmall protein activating enzyme binding
B0044389molecular_functionubiquitin-like protein ligase binding
B0045759biological_processnegative regulation of action potential
B0045892biological_processnegative regulation of DNA-templated transcription
B0050821biological_processprotein stabilization
B0060021biological_processroof of mouth development
B0060633biological_processnegative regulation of transcription initiation by RNA polymerase II
B0071276biological_processcellular response to cadmium ion
B0086004biological_processregulation of cardiac muscle cell contraction
B0097165cellular_componentnuclear stress granule
B0141109molecular_functiontransporter activator activity
B1903169biological_processregulation of calcium ion transmembrane transport
B1990381molecular_functionubiquitin-specific protease binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI2
Number of Residues3
DetailsRegion: {"description":"(Microbial infection) Interaction with Tula hantavirus","evidences":[{"source":"PubMed","id":"12606074","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsSite: {"description":"Interaction with PIAS2"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues5
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

258009

PDB entries from 2026-08-12

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