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9LDB

DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004459molecular_functionL-lactate dehydrogenase activity
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0006089biological_processlactate metabolic process
A0006090biological_processpyruvate metabolic process
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0019752biological_processcarboxylic acid metabolic process
A0042802molecular_functionidentical protein binding
A1990204cellular_componentoxidoreductase complex
B0003824molecular_functioncatalytic activity
B0004459molecular_functionL-lactate dehydrogenase activity
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0006089biological_processlactate metabolic process
B0006090biological_processpyruvate metabolic process
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0019752biological_processcarboxylic acid metabolic process
B0042802molecular_functionidentical protein binding
B1990204cellular_componentoxidoreductase complex
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 402
ChainResidue
AARG109
AASN140
AARG171
AHIS195
AALA236
ATHR246
ANAD401

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 403
ChainResidue
AHIS188
AHOH430
AHOH433
AHOH446
AHOH450
AARG173
AHIS188

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 403
ChainResidue
BARG173
BHIS188
BHIS188
BHOH442
BHOH444
BHOH462
BHOH463

site_idAC4
Number of Residues30
DetailsBINDING SITE FOR RESIDUE NAD A 401
ChainResidue
AGLY30
AALA31
AVAL32
AASP53
AVAL54
AMET55
ATHR97
AALA98
AGLY99
AALA100
AARG101
APHE122
AILE123
AVAL138
AASN140
ASER163
ALEU167
AHIS195
ATHR246
AILE250
ASO4402
AHOH404
AHOH411
AHOH413
AHOH424
AHOH429
AHOH442
AHOH464
BHOH425
BHOH473

site_idAC5
Number of Residues24
DetailsBINDING SITE FOR RESIDUE NAD B 401
ChainResidue
BGLY30
BALA31
BVAL32
BASP53
BVAL54
BMET55
BTHR97
BALA98
BGLY99
BALA100
BARG101
BILE119
BVAL138
BASN140
BSER163
BHIS195
BTHR246
BILE250
BOXM402
BHOH407
BHOH414
BHOH416
BHOH429
BHOH441

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE OXM B 402
ChainResidue
BGLN102
BARG109
BASN140
BARG171
BHIS195
BALA236
BTHR246
BNAD401

Functional Information from PROSITE/UniProt
site_idPS00064
Number of Residues7
DetailsL_LDH L-lactate dehydrogenase active site. LGEHGDS
ChainResidueDetails
ALEU192-SER198

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AGLY196
BGLY196

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:1678537
ChainResidueDetails
AALA31
AGLN102
BALA31
BGLN102

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING:
ChainResidueDetails
ALEU110
APRO141
APHE172
ASER247
BLEU110
BPRO141
BPHE172
BSER247

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:838465
ChainResidueDetails
ATHR2
BTHR2

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P06151
ChainResidueDetails
AASP5
APHE122
ASER318
BASP5
BPHE122
BSER318

site_idSWS_FT_FI6
Number of Residues6
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P00338
ChainResidueDetails
AGLU14
AASP84
ATYR130
BGLU14
BASP84
BTYR130

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P00338
ChainResidueDetails
ALEU59
BLEU59

site_idSWS_FT_FI8
Number of Residues6
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P06151
ChainResidueDetails
AGLU223
AGLU231
ALEU242
BGLU223
BGLU231
BLEU242

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P06151
ChainResidueDetails
AGLU238
BGLU238

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P04642
ChainResidueDetails
APRO309
ALEU322
BPRO309
BLEU322

site_idSWS_FT_FI11
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P00338
ChainResidueDetails
ALEU59
BLEU59

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PDB entries from 2024-03-27

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