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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9L8W

Human KCNQ2-CaM in complex with QO-58

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0001508biological_processaction potential
A0005216molecular_functionmonoatomic ion channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0007268biological_processchemical synaptic transmission
A0007399biological_processnervous system development
A0008076cellular_componentvoltage-gated potassium channel complex
A0016020cellular_componentmembrane
A0022843molecular_functionvoltage-gated monoatomic cation channel activity
A0030506molecular_functionankyrin binding
A0033268cellular_componentnode of Ranvier
A0043194cellular_componentaxon initial segment
A0045202cellular_componentsynapse
A0055085biological_processtransmembrane transport
A0071805biological_processpotassium ion transmembrane transport
B0001508biological_processaction potential
B0005216molecular_functionmonoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0007268biological_processchemical synaptic transmission
B0007399biological_processnervous system development
B0008076cellular_componentvoltage-gated potassium channel complex
B0016020cellular_componentmembrane
B0022843molecular_functionvoltage-gated monoatomic cation channel activity
B0030506molecular_functionankyrin binding
B0033268cellular_componentnode of Ranvier
B0043194cellular_componentaxon initial segment
B0045202cellular_componentsynapse
B0055085biological_processtransmembrane transport
B0071805biological_processpotassium ion transmembrane transport
C0001508biological_processaction potential
C0005216molecular_functionmonoatomic ion channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0007268biological_processchemical synaptic transmission
C0007399biological_processnervous system development
C0008076cellular_componentvoltage-gated potassium channel complex
C0016020cellular_componentmembrane
C0022843molecular_functionvoltage-gated monoatomic cation channel activity
C0030506molecular_functionankyrin binding
C0033268cellular_componentnode of Ranvier
C0043194cellular_componentaxon initial segment
C0045202cellular_componentsynapse
C0055085biological_processtransmembrane transport
C0071805biological_processpotassium ion transmembrane transport
D0001508biological_processaction potential
D0005216molecular_functionmonoatomic ion channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0007268biological_processchemical synaptic transmission
D0007399biological_processnervous system development
D0008076cellular_componentvoltage-gated potassium channel complex
D0016020cellular_componentmembrane
D0022843molecular_functionvoltage-gated monoatomic cation channel activity
D0030506molecular_functionankyrin binding
D0033268cellular_componentnode of Ranvier
D0043194cellular_componentaxon initial segment
D0045202cellular_componentsynapse
D0055085biological_processtransmembrane transport
D0071805biological_processpotassium ion transmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues160
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues112
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues72
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues100
DetailsTransmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues48
DetailsIntramembrane: {"description":"Pore-forming; Name=Segment H5","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues104
DetailsTransmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues404
DetailsRegion: {"description":"Mediates interaction with SLC5A3/SMIT1","evidences":[{"source":"UniProtKB","id":"O88943","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues20
DetailsMotif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"37857637","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8J01","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8W4U","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"37857637","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8W4U","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"16319223","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2026-08-05

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