9KYU

Structure of beta-arrestin1 in complex with mouse C5aR1pp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000785	cellular_component	chromatin
A	0001664	molecular_function	G protein-coupled receptor binding
A	0001678	biological_process	intracellular glucose homeostasis
A	0001933	biological_process	negative regulation of protein phosphorylation
A	0001934	biological_process	positive regulation of protein phosphorylation
A	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
A	0002031	biological_process	G protein-coupled receptor internalization
A	0002092	biological_process	positive regulation of receptor internalization
A	0003713	molecular_function	transcription coactivator activity
A	0004402	molecular_function	histone acetyltransferase activity
A	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
A	0005096	molecular_function	GTPase activator activity
A	0005102	molecular_function	signaling receptor binding
A	0005159	molecular_function	insulin-like growth factor receptor binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005905	cellular_component	clathrin-coated pit
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006897	biological_process	endocytosis
A	0007166	biological_process	cell surface receptor signaling pathway
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
A	0007600	biological_process	sensory perception
A	0007602	biological_process	phototransduction
A	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009410	biological_process	response to xenobiotic stimulus
A	0009968	biological_process	negative regulation of signal transduction
A	0014069	cellular_component	postsynaptic density
A	0015031	biological_process	protein transport
A	0016323	cellular_component	basolateral plasma membrane
A	0016567	biological_process	protein ubiquitination
A	0019899	molecular_function	enzyme binding
A	0030276	molecular_function	clathrin binding
A	0030331	molecular_function	nuclear estrogen receptor binding
A	0031143	cellular_component	pseudopodium
A	0031396	biological_process	regulation of protein ubiquitination
A	0031397	biological_process	negative regulation of protein ubiquitination
A	0031398	biological_process	positive regulation of protein ubiquitination
A	0031410	cellular_component	cytoplasmic vesicle
A	0031434	molecular_function	mitogen-activated protein kinase kinase binding
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0031691	molecular_function	alpha-1A adrenergic receptor binding
A	0031692	molecular_function	alpha-1B adrenergic receptor binding
A	0031701	molecular_function	angiotensin receptor binding
A	0031762	molecular_function	follicle-stimulating hormone receptor binding
A	0031896	molecular_function	V2 vasopressin receptor binding
A	0032715	biological_process	negative regulation of interleukin-6 production
A	0032717	biological_process	negative regulation of interleukin-8 production
A	0032960	biological_process	regulation of inositol trisphosphate biosynthetic process
A	0034260	biological_process	negative regulation of GTPase activity
A	0035025	biological_process	positive regulation of Rho protein signal transduction
A	0035612	molecular_function	AP-2 adaptor complex binding
A	0035615	molecular_function	clathrin adaptor activity
A	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
A	0042699	biological_process	follicle-stimulating hormone signaling pathway
A	0042981	biological_process	regulation of apoptotic process
A	0043066	biological_process	negative regulation of apoptotic process
A	0043149	biological_process	stress fiber assembly
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043197	cellular_component	dendritic spine
A	0043278	biological_process	response to morphine
A	0043410	biological_process	positive regulation of MAPK cascade
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0044325	molecular_function	transmembrane transporter binding
A	0045211	cellular_component	postsynaptic membrane
A	0045309	molecular_function	protein phosphorylated amino acid binding
A	0045746	biological_process	negative regulation of Notch signaling pathway
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0050975	biological_process	sensory perception of touch
A	0051219	molecular_function	phosphoprotein binding
A	0060090	molecular_function	molecular adaptor activity
A	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0098978	cellular_component	glutamatergic synapse
A	1902533	biological_process	positive regulation of intracellular signal transduction
A	1990763	molecular_function	arrestin family protein binding
D	0000785	cellular_component	chromatin
D	0001664	molecular_function	G protein-coupled receptor binding
D	0001678	biological_process	intracellular glucose homeostasis
D	0001933	biological_process	negative regulation of protein phosphorylation
D	0001934	biological_process	positive regulation of protein phosphorylation
D	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
D	0002031	biological_process	G protein-coupled receptor internalization
D	0002092	biological_process	positive regulation of receptor internalization
D	0003713	molecular_function	transcription coactivator activity
D	0004402	molecular_function	histone acetyltransferase activity
D	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
D	0005096	molecular_function	GTPase activator activity
D	0005102	molecular_function	signaling receptor binding
D	0005159	molecular_function	insulin-like growth factor receptor binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005768	cellular_component	endosome
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005905	cellular_component	clathrin-coated pit
D	0006351	biological_process	DNA-templated transcription
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006897	biological_process	endocytosis
D	0007166	biological_process	cell surface receptor signaling pathway
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
D	0007600	biological_process	sensory perception
D	0007602	biological_process	phototransduction
D	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
D	0008284	biological_process	positive regulation of cell population proliferation
D	0009410	biological_process	response to xenobiotic stimulus
D	0009968	biological_process	negative regulation of signal transduction
D	0014069	cellular_component	postsynaptic density
D	0015031	biological_process	protein transport
D	0016323	cellular_component	basolateral plasma membrane
D	0016567	biological_process	protein ubiquitination
D	0019899	molecular_function	enzyme binding
D	0030276	molecular_function	clathrin binding
D	0030331	molecular_function	nuclear estrogen receptor binding
D	0031143	cellular_component	pseudopodium
D	0031396	biological_process	regulation of protein ubiquitination
D	0031397	biological_process	negative regulation of protein ubiquitination
D	0031398	biological_process	positive regulation of protein ubiquitination
D	0031410	cellular_component	cytoplasmic vesicle
D	0031434	molecular_function	mitogen-activated protein kinase kinase binding
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0031691	molecular_function	alpha-1A adrenergic receptor binding
D	0031692	molecular_function	alpha-1B adrenergic receptor binding
D	0031701	molecular_function	angiotensin receptor binding
D	0031762	molecular_function	follicle-stimulating hormone receptor binding
D	0031896	molecular_function	V2 vasopressin receptor binding
D	0032715	biological_process	negative regulation of interleukin-6 production
D	0032717	biological_process	negative regulation of interleukin-8 production
D	0032960	biological_process	regulation of inositol trisphosphate biosynthetic process
D	0034260	biological_process	negative regulation of GTPase activity
D	0035025	biological_process	positive regulation of Rho protein signal transduction
D	0035612	molecular_function	AP-2 adaptor complex binding
D	0035615	molecular_function	clathrin adaptor activity
D	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
D	0042699	biological_process	follicle-stimulating hormone signaling pathway
D	0042981	biological_process	regulation of apoptotic process
D	0043066	biological_process	negative regulation of apoptotic process
D	0043149	biological_process	stress fiber assembly
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043197	cellular_component	dendritic spine
D	0043278	biological_process	response to morphine
D	0043410	biological_process	positive regulation of MAPK cascade
D	0043524	biological_process	negative regulation of neuron apoptotic process
D	0044325	molecular_function	transmembrane transporter binding
D	0045211	cellular_component	postsynaptic membrane
D	0045309	molecular_function	protein phosphorylated amino acid binding
D	0045746	biological_process	negative regulation of Notch signaling pathway
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0050975	biological_process	sensory perception of touch
D	0051219	molecular_function	phosphoprotein binding
D	0060090	molecular_function	molecular adaptor activity
D	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
D	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
D	0098978	cellular_component	glutamatergic synapse
D	1902533	biological_process	positive regulation of intracellular signal transduction
D	1990763	molecular_function	arrestin family protein binding

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
I	TYR204-HIS210
M	TYR193-HIS199

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site_id	PS00295
Number of Residues	19
Details	ARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL

Chain	Residue	Details
A	PHE61-LEU79

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8BWG8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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