9KVX

Cryo-EM structure of SLC30A10 in Mn2+-bound state, determined in inward-facing conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0005384	molecular_function	manganese ion transmembrane transporter activity
A	0005385	molecular_function	zinc ion transmembrane transporter activity
A	0005515	molecular_function	protein binding
A	0005765	cellular_component	lysosomal membrane
A	0005769	cellular_component	early endosome
A	0005794	cellular_component	Golgi apparatus
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006828	biological_process	manganese ion transport
A	0006829	biological_process	zinc ion transport
A	0006878	biological_process	intracellular copper ion homeostasis
A	0006882	biological_process	intracellular zinc ion homeostasis
A	0007173	biological_process	epidermal growth factor receptor signaling pathway
A	0008021	cellular_component	synaptic vesicle
A	0010312	biological_process	detoxification of zinc ion
A	0015297	molecular_function	antiporter activity
A	0016020	cellular_component	membrane
A	0030001	biological_process	metal ion transport
A	0030026	biological_process	intracellular manganese ion homeostasis
A	0031410	cellular_component	cytoplasmic vesicle
A	0031901	cellular_component	early endosome membrane
A	0055037	cellular_component	recycling endosome
A	0055038	cellular_component	recycling endosome membrane
A	0055071	biological_process	manganese ion homeostasis
A	0062111	biological_process	zinc ion import into organelle
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0071577	biological_process	zinc ion transmembrane transport
A	0140048	biological_process	manganese ion export across plasma membrane
A	0140983	molecular_function	calcium:manganese antiporter activity
A	1902495	cellular_component	transmembrane transporter complex
A	1904385	biological_process	cellular response to angiotensin
B	0000139	cellular_component	Golgi membrane
B	0005384	molecular_function	manganese ion transmembrane transporter activity
B	0005385	molecular_function	zinc ion transmembrane transporter activity
B	0005515	molecular_function	protein binding
B	0005765	cellular_component	lysosomal membrane
B	0005769	cellular_component	early endosome
B	0005794	cellular_component	Golgi apparatus
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006828	biological_process	manganese ion transport
B	0006829	biological_process	zinc ion transport
B	0006878	biological_process	intracellular copper ion homeostasis
B	0006882	biological_process	intracellular zinc ion homeostasis
B	0007173	biological_process	epidermal growth factor receptor signaling pathway
B	0008021	cellular_component	synaptic vesicle
B	0010312	biological_process	detoxification of zinc ion
B	0015297	molecular_function	antiporter activity
B	0016020	cellular_component	membrane
B	0030001	biological_process	metal ion transport
B	0030026	biological_process	intracellular manganese ion homeostasis
B	0031410	cellular_component	cytoplasmic vesicle
B	0031901	cellular_component	early endosome membrane
B	0055037	cellular_component	recycling endosome
B	0055038	cellular_component	recycling endosome membrane
B	0055071	biological_process	manganese ion homeostasis
B	0062111	biological_process	zinc ion import into organelle
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	0071577	biological_process	zinc ion transmembrane transport
B	0140048	biological_process	manganese ion export across plasma membrane
B	0140983	molecular_function	calcium:manganese antiporter activity
B	1902495	cellular_component	transmembrane transporter complex
B	1904385	biological_process	cellular response to angiotensin

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	200
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	60
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	38
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Important for coupling of manganese to calcium transport","evidences":[{"source":"PubMed","id":"30755481","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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