Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9KVV

Cryo-EM structure of human G6PT in complex with G6P

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006006	biological_process	glucose metabolic process
A	0006094	biological_process	gluconeogenesis
A	0015152	molecular_function	glucose-6-phosphate transmembrane transporter activity
A	0015760	biological_process	glucose-6-phosphate transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0035435	biological_process	phosphate ion transmembrane transport
A	0055085	biological_process	transmembrane transport
A	0061513	molecular_function	glucose 6-phosphate:phosphate antiporter activity

Functional Information from PROSITE/UniProt

site_id	PS00942
Number of Residues	17
Details	GLPT glpT family of transporters signature. QFGtwwAILStSMNLAG

Chain	Residue	Details
A	GLN133-GLY149

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"41136424","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41225049","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9KUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	60
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"41136424","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41225049","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9KUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"41136424","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41225049","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9KUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	58
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"41136424","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41225049","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9KUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"41136424","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41225049","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9KUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"41136424","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41225049","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9KUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"41136424","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41225049","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9KUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"41136424","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41225049","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9KUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"41136424","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41225049","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9KUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"41136424","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41225049","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9KUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"41136424","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41225049","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9KUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"41136424","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41225049","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9KUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"41136424","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41225049","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9KUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"41136424","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41225049","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9KUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9KVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9W1R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"41225049","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9W1P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"41225049","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9W1O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"41136424","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9KVV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)