9KUX

Cryo-EM structure of dimeric APJR and one Beta-arrestin complex with small molecules

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
Q	0001525	biological_process	angiogenesis
Q	0001568	biological_process	blood vessel development
Q	0001570	biological_process	vasculogenesis
Q	0001944	biological_process	vasculature development
Q	0001947	biological_process	heart looping
Q	0003171	biological_process	atrioventricular valve development
Q	0003272	biological_process	endocardial cushion formation
Q	0004930	molecular_function	G protein-coupled receptor activity
Q	0005515	molecular_function	protein binding
Q	0005886	cellular_component	plasma membrane
Q	0007165	biological_process	signal transduction
Q	0007186	biological_process	G protein-coupled receptor signaling pathway
Q	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Q	0007369	biological_process	gastrulation
Q	0007507	biological_process	heart development
Q	0007512	biological_process	adult heart development
Q	0008528	molecular_function	G protein-coupled peptide receptor activity
Q	0010468	biological_process	regulation of gene expression
Q	0010629	biological_process	negative regulation of gene expression
Q	0035886	biological_process	vascular associated smooth muscle cell differentiation
Q	0035904	biological_process	aorta development
Q	0038023	molecular_function	signaling receptor activity
Q	0045766	biological_process	positive regulation of angiogenesis
Q	0050878	biological_process	regulation of body fluid levels
Q	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
Q	0060182	molecular_function	apelin receptor activity
Q	0060183	biological_process	apelin receptor signaling pathway
Q	0060412	biological_process	ventricular septum morphogenesis
Q	0060841	biological_process	venous blood vessel development
Q	0060976	biological_process	coronary vasculature development
Q	0140897	molecular_function	mechanoreceptor activity
Q	1903243	biological_process	negative regulation of cardiac muscle hypertrophy in response to stress
Q	1903244	biological_process	positive regulation of cardiac muscle hypertrophy in response to stress
Q	1903589	biological_process	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Q	1903596	biological_process	regulation of gap junction assembly
Q	1904022	biological_process	positive regulation of G protein-coupled receptor internalization
R	0001525	biological_process	angiogenesis
R	0001568	biological_process	blood vessel development
R	0001570	biological_process	vasculogenesis
R	0001944	biological_process	vasculature development
R	0001947	biological_process	heart looping
R	0003171	biological_process	atrioventricular valve development
R	0003272	biological_process	endocardial cushion formation
R	0004930	molecular_function	G protein-coupled receptor activity
R	0005515	molecular_function	protein binding
R	0005886	cellular_component	plasma membrane
R	0007165	biological_process	signal transduction
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
R	0007369	biological_process	gastrulation
R	0007507	biological_process	heart development
R	0007512	biological_process	adult heart development
R	0008528	molecular_function	G protein-coupled peptide receptor activity
R	0010468	biological_process	regulation of gene expression
R	0010629	biological_process	negative regulation of gene expression
R	0035886	biological_process	vascular associated smooth muscle cell differentiation
R	0035904	biological_process	aorta development
R	0038023	molecular_function	signaling receptor activity
R	0045766	biological_process	positive regulation of angiogenesis
R	0050878	biological_process	regulation of body fluid levels
R	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
R	0060182	molecular_function	apelin receptor activity
R	0060183	biological_process	apelin receptor signaling pathway
R	0060412	biological_process	ventricular septum morphogenesis
R	0060841	biological_process	venous blood vessel development
R	0060976	biological_process	coronary vasculature development
R	0140897	molecular_function	mechanoreceptor activity
R	1903243	biological_process	negative regulation of cardiac muscle hypertrophy in response to stress
R	1903244	biological_process	positive regulation of cardiac muscle hypertrophy in response to stress
R	1903589	biological_process	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
R	1903596	biological_process	regulation of gap junction assembly
R	1904022	biological_process	positive regulation of G protein-coupled receptor internalization

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVfCLTGLSFDRYLaI

Chain	Residue	Details
Q	ALA115-ILE131

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site_id	PS00295
Number of Residues	19
Details	ARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL

Chain	Residue	Details
A	PHE61-LEU79

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