9KUV
Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| R | 0001525 | biological_process | angiogenesis |
| R | 0001568 | biological_process | blood vessel development |
| R | 0001570 | biological_process | vasculogenesis |
| R | 0001944 | biological_process | vasculature development |
| R | 0001947 | biological_process | heart looping |
| R | 0003171 | biological_process | atrioventricular valve development |
| R | 0003272 | biological_process | endocardial cushion formation |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0005515 | molecular_function | protein binding |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0007165 | biological_process | signal transduction |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007193 | biological_process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| R | 0007369 | biological_process | gastrulation |
| R | 0007507 | biological_process | heart development |
| R | 0007512 | biological_process | adult heart development |
| R | 0008528 | molecular_function | G protein-coupled peptide receptor activity |
| R | 0010468 | biological_process | regulation of gene expression |
| R | 0010629 | biological_process | negative regulation of gene expression |
| R | 0035886 | biological_process | vascular associated smooth muscle cell differentiation |
| R | 0035904 | biological_process | aorta development |
| R | 0038023 | molecular_function | signaling receptor activity |
| R | 0045766 | biological_process | positive regulation of angiogenesis |
| R | 0050878 | biological_process | regulation of body fluid levels |
| R | 0051281 | biological_process | positive regulation of release of sequestered calcium ion into cytosol |
| R | 0060182 | molecular_function | apelin receptor activity |
| R | 0060183 | biological_process | apelin receptor signaling pathway |
| R | 0060412 | biological_process | ventricular septum morphogenesis |
| R | 0060841 | biological_process | venous blood vessel development |
| R | 0060976 | biological_process | coronary vasculature development |
| R | 0140897 | molecular_function | mechanoreceptor activity |
| R | 1903243 | biological_process | negative regulation of cardiac muscle hypertrophy in response to stress |
| R | 1903244 | biological_process | positive regulation of cardiac muscle hypertrophy in response to stress |
| R | 1903589 | biological_process | positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| R | 1903596 | biological_process | regulation of gap junction assembly |
| R | 1904022 | biological_process | positive regulation of G protein-coupled receptor internalization |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 51 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 63 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Site: {"description":"Required for APELA and APLN/apelin-13 interaction and signaling","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38428423","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
