9KQF
Cryo-EM structure of PSS1 in the absence of calcium or L-serine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006659 | biological_process | phosphatidylserine biosynthetic process |
| A | 0008654 | biological_process | phospholipid biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0106245 | molecular_function | L-serine-phosphatidylethanolamine phosphatidyltransferase activity |
| A | 0106258 | molecular_function | L-serine-phosphatidylcholine phosphatidyltransferase activity |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006659 | biological_process | phosphatidylserine biosynthetic process |
| B | 0008654 | biological_process | phospholipid biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0106245 | molecular_function | L-serine-phosphatidylethanolamine phosphatidyltransferase activity |
| B | 0106258 | molecular_function | L-serine-phosphatidylcholine phosphatidyltransferase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 132 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA2-ASP35 | |
| B | SER377-TYR383 | |
| A | THR94-ARG102 | |
| A | PRO208-ASP216 | |
| A | LYS308-LEU319 | |
| A | SER377-TYR383 | |
| B | ALA2-ASP35 | |
| B | THR94-ARG102 | |
| B | PRO208-ASP216 | |
| B | LYS308-LEU319 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 364 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE36-PHE56 | |
| B | PHE36-PHE56 | |
| B | ILE73-PHE93 | |
| B | MET103-PHE123 | |
| B | GLY187-LEU207 | |
| B | GLN217-CYS237 | |
| B | VAL287-LEU307 | |
| B | SER320-LEU342 | |
| B | VAL356-PHE376 | |
| B | VAL384-TRP404 | |
| A | ILE73-PHE93 | |
| A | MET103-PHE123 | |
| A | GLY187-LEU207 | |
| A | GLN217-CYS237 | |
| A | VAL287-LEU307 | |
| A | SER320-LEU342 | |
| A | VAL356-PHE376 | |
| A | VAL384-TRP404 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 410 |
| Details | TOPO_DOM: Lumenal => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA57-GLY72 | |
| B | TYR405-LYS473 | |
| A | GLU124-TYR186 | |
| A | ARG238-ARG286 | |
| A | THR343-TRP355 | |
| A | TYR405-LYS473 | |
| B | ALA57-GLY72 | |
| B | GLU124-TYR186 | |
| B | ARG238-ARG286 | |
| B | THR343-TRP355 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:25944712 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER417 | |
| A | SER425 | |
| B | SER417 | |
| B | SER425 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | SER442 | |
| B | SER442 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | SER454 | |
| B | SER454 |
