9KQ5

Cryo-EM structure of human VAChT at protonated state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005277	molecular_function	acetylcholine transmembrane transporter activity
A	0005278	molecular_function	acetylcholine:proton antiporter activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006836	biological_process	neurotransmitter transport
A	0007268	biological_process	chemical synaptic transmission
A	0014057	biological_process	positive regulation of acetylcholine secretion, neurotransmission
A	0015311	molecular_function	monoamine:proton antiporter activity
A	0030121	cellular_component	AP-1 adaptor complex
A	0030122	cellular_component	AP-2 adaptor complex
A	0030669	cellular_component	clathrin-coated endocytic vesicle membrane
A	0030672	cellular_component	synaptic vesicle membrane
A	0043195	cellular_component	terminal bouton
A	0051610	biological_process	serotonin uptake
A	0051630	biological_process	acetylcholine uptake
A	0060201	cellular_component	clathrin-sculpted acetylcholine transport vesicle membrane
A	1900273	biological_process	positive regulation of long-term synaptic potentiation
A	1902600	biological_process	proton transmembrane transport
A	1904398	biological_process	positive regulation of neuromuscular junction development

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	60
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	42
Details	Topological domain: {"description":"Lumenal, vesicle","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Important for transporter activity","evidences":[{"source":"UniProtKB","id":"Q62666","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Important for transporter activity","evidences":[{"source":"PubMed","id":"20225888","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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