9KO6

A local Cryo_EM structure of CCR7 complex with CCL19

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0001768	biological_process	establishment of T cell polarity
C	0001771	biological_process	immunological synapse formation
C	0002407	biological_process	dendritic cell chemotaxis
C	0002408	biological_process	myeloid dendritic cell chemotaxis
C	0002606	biological_process	positive regulation of dendritic cell antigen processing and presentation
C	0005125	molecular_function	cytokine activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006874	biological_process	intracellular calcium ion homeostasis
C	0006935	biological_process	chemotaxis
C	0006954	biological_process	inflammatory response
C	0006955	biological_process	immune response
C	0007154	biological_process	cell communication
C	0008009	molecular_function	chemokine activity
C	0009615	biological_process	response to virus
C	0010560	biological_process	positive regulation of glycoprotein biosynthetic process
C	0030335	biological_process	positive regulation of cell migration
C	0031295	biological_process	T cell costimulation
C	0031732	molecular_function	CCR7 chemokine receptor binding
C	0031735	molecular_function	CCR10 chemokine receptor binding
C	0032489	biological_process	regulation of Cdc42 protein signal transduction
C	0032731	biological_process	positive regulation of interleukin-1 beta production
C	0032735	biological_process	positive regulation of interleukin-12 production
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0035022	biological_process	positive regulation of Rac protein signal transduction
C	0038119	biological_process	CCL19-activated CCR7 signaling pathway
C	0042102	biological_process	positive regulation of T cell proliferation
C	0042379	molecular_function	chemokine receptor binding
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0045627	biological_process	positive regulation of T-helper 1 cell differentiation
C	0045807	biological_process	positive regulation of endocytosis
C	0046330	biological_process	positive regulation of JNK cascade
C	0048020	molecular_function	CCR chemokine receptor binding
C	0048245	biological_process	eosinophil chemotaxis
C	0048260	biological_process	positive regulation of receptor-mediated endocytosis
C	0048469	biological_process	cell maturation
C	0050921	biological_process	positive regulation of chemotaxis
C	0051209	biological_process	release of sequestered calcium ion into cytosol
C	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C	0060491	biological_process	regulation of cell projection assembly
C	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
C	0070098	biological_process	chemokine-mediated signaling pathway
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	0071380	biological_process	cellular response to prostaglandin E stimulus
C	0071731	biological_process	response to nitric oxide
C	0090023	biological_process	positive regulation of neutrophil chemotaxis
C	0097029	biological_process	mature conventional dendritic cell differentiation
C	0098586	biological_process	cellular response to virus
C	0141214	biological_process	positive regulation of phospholipase C/protein kinase C signal transduction
C	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
C	2000147	biological_process	positive regulation of cell motility
C	2000549	biological_process	positive regulation of dendritic cell dendrite assembly
C	2000669	biological_process	negative regulation of dendritic cell apoptotic process
R	0001768	biological_process	establishment of T cell polarity
R	0001954	biological_process	positive regulation of cell-matrix adhesion
R	0002407	biological_process	dendritic cell chemotaxis
R	0002408	biological_process	myeloid dendritic cell chemotaxis
R	0002606	biological_process	positive regulation of dendritic cell antigen processing and presentation
R	0002885	biological_process	positive regulation of hypersensitivity
R	0002922	biological_process	positive regulation of humoral immune response
R	0004930	molecular_function	G protein-coupled receptor activity
R	0005739	cellular_component	mitochondrion
R	0005886	cellular_component	plasma membrane
R	0006954	biological_process	inflammatory response
R	0006955	biological_process	immune response
R	0007165	biological_process	signal transduction
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
R	0009897	cellular_component	external side of plasma membrane
R	0009986	cellular_component	cell surface
R	0016493	molecular_function	C-C chemokine receptor activity
R	0019722	biological_process	calcium-mediated signaling
R	0030838	biological_process	positive regulation of actin filament polymerization
R	0031274	biological_process	positive regulation of pseudopodium assembly
R	0031529	biological_process	ruffle organization
R	0032489	biological_process	regulation of Cdc42 protein signal transduction
R	0032496	biological_process	response to lipopolysaccharide
R	0032649	biological_process	regulation of type II interferon production
R	0032651	biological_process	regulation of interleukin-1 beta production
R	0032695	biological_process	negative regulation of interleukin-12 production
R	0032735	biological_process	positive regulation of interleukin-12 production
R	0035022	biological_process	positive regulation of Rac protein signal transduction
R	0035757	molecular_function	chemokine (C-C motif) ligand 19 binding
R	0035758	molecular_function	chemokine (C-C motif) ligand 21 binding
R	0038117	molecular_function	C-C motif chemokine 19 receptor activity
R	0038119	biological_process	CCL19-activated CCR7 signaling pathway
R	0038120	biological_process	CCL21-activated CCR7 signaling pathway
R	0038121	molecular_function	C-C motif chemokine 21 receptor activity
R	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
R	0045060	biological_process	negative thymic T cell selection
R	0045785	biological_process	positive regulation of cell adhesion
R	0046330	biological_process	positive regulation of JNK cascade
R	0048260	biological_process	positive regulation of receptor-mediated endocytosis
R	0050862	biological_process	positive regulation of T cell receptor signaling pathway
R	0051209	biological_process	release of sequestered calcium ion into cytosol
R	0051491	biological_process	positive regulation of filopodium assembly
R	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
R	0060326	biological_process	cell chemotaxis
R	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
R	0071345	biological_process	cellular response to cytokine stimulus
R	0071380	biological_process	cellular response to prostaglandin E stimulus
R	0071731	biological_process	response to nitric oxide
R	0090023	biological_process	positive regulation of neutrophil chemotaxis
R	0097022	biological_process	lymphocyte migration into lymph node
R	0097029	biological_process	mature conventional dendritic cell differentiation
R	0141214	biological_process	positive regulation of phospholipase C/protein kinase C signal transduction
R	2000147	biological_process	positive regulation of cell motility
R	2000510	biological_process	positive regulation of dendritic cell chemotaxis
R	2000522	biological_process	positive regulation of immunological synapse formation
R	2000525	biological_process	positive regulation of T cell costimulation
R	2000526	biological_process	positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
R	2000547	biological_process	regulation of dendritic cell dendrite assembly
R	2000669	biological_process	negative regulation of dendritic cell apoptotic process

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SGMlLLLCISIDRYVaI

Chain	Residue	Details
R	SER142-ILE158

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site_id	PS00472
Number of Residues	44
Details	SMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCLsvtqkp..IpgyiVrnFhyllikdgCrvp.AVVFttlrgrql.CA

Chain	Residue	Details
C	CYS8-ALA51

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	40
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	27
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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