9KL5
Cryo-EM strucuture of human OAT1 in complex with probenecid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005452 | molecular_function | solute:inorganic anion antiporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005901 | cellular_component | caveola |
| A | 0009925 | cellular_component | basal plasma membrane |
| A | 0015132 | molecular_function | prostaglandin transmembrane transporter activity |
| A | 0015139 | molecular_function | alpha-ketoglutarate transmembrane transporter activity |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015711 | biological_process | organic anion transport |
| A | 0015732 | biological_process | prostaglandin transport |
| A | 0015742 | biological_process | alpha-ketoglutarate transport |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0043252 | biological_process | sodium-independent organic anion transport |
| A | 0051260 | biological_process | protein homooligomerization |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0072237 | biological_process | metanephric proximal tubule development |
| A | 0097254 | biological_process | renal tubular secretion |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 243 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 30 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 29 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for interaction with cidofovir"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for interaction with cidofovir and PAH"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14749323","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10462545","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
