Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9KJT

The cryo-EM structure of human PNPase in the closed conformation

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000175	molecular_function	3'-5'-RNA exonuclease activity
A	0000957	biological_process	mitochondrial RNA catabolic process
A	0000958	biological_process	mitochondrial mRNA catabolic process
A	0000962	biological_process	positive regulation of mitochondrial RNA catabolic process
A	0000964	biological_process	mitochondrial RNA 5'-end processing
A	0000965	biological_process	mitochondrial RNA 3'-end processing
A	0003723	molecular_function	RNA binding
A	0004518	molecular_function	nuclease activity
A	0004527	molecular_function	exonuclease activity
A	0004654	molecular_function	polyribonucleotide nucleotidyltransferase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005759	cellular_component	mitochondrial matrix
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005840	cellular_component	ribosome
A	0006396	biological_process	RNA processing
A	0006397	biological_process	mRNA processing
A	0006401	biological_process	RNA catabolic process
A	0006402	biological_process	mRNA catabolic process
A	0007005	biological_process	mitochondrion organization
A	0008266	molecular_function	poly(U) RNA binding
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0034046	molecular_function	poly(G) binding
A	0034599	biological_process	cellular response to oxidative stress
A	0035198	molecular_function	miRNA binding
A	0035458	biological_process	cellular response to interferon-beta
A	0035927	biological_process	RNA import into mitochondrion
A	0035928	biological_process	rRNA import into mitochondrion
A	0042802	molecular_function	identical protein binding
A	0043457	biological_process	regulation of cellular respiration
A	0043631	biological_process	obsolete RNA polyadenylation
A	0045025	cellular_component	mitochondrial degradosome
A	0051260	biological_process	protein homooligomerization
A	0051591	biological_process	response to cAMP
A	0060416	biological_process	response to growth hormone
A	0061014	biological_process	positive regulation of mRNA catabolic process
A	0070207	biological_process	protein homotrimerization
A	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
A	0097222	biological_process	mitochondrial mRNA polyadenylation
A	0097421	biological_process	liver regeneration
A	1905354	cellular_component	exoribonuclease complex
A	2000627	biological_process	positive regulation of miRNA catabolic process
A	2000772	biological_process	regulation of cellular senescence
B	0000175	molecular_function	3'-5'-RNA exonuclease activity
B	0000957	biological_process	mitochondrial RNA catabolic process
B	0000958	biological_process	mitochondrial mRNA catabolic process
B	0000962	biological_process	positive regulation of mitochondrial RNA catabolic process
B	0000964	biological_process	mitochondrial RNA 5'-end processing
B	0000965	biological_process	mitochondrial RNA 3'-end processing
B	0003723	molecular_function	RNA binding
B	0004518	molecular_function	nuclease activity
B	0004527	molecular_function	exonuclease activity
B	0004654	molecular_function	polyribonucleotide nucleotidyltransferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005759	cellular_component	mitochondrial matrix
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0005840	cellular_component	ribosome
B	0006396	biological_process	RNA processing
B	0006397	biological_process	mRNA processing
B	0006401	biological_process	RNA catabolic process
B	0006402	biological_process	mRNA catabolic process
B	0007005	biological_process	mitochondrion organization
B	0008266	molecular_function	poly(U) RNA binding
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0016787	molecular_function	hydrolase activity
B	0034046	molecular_function	poly(G) binding
B	0034599	biological_process	cellular response to oxidative stress
B	0035198	molecular_function	miRNA binding
B	0035458	biological_process	cellular response to interferon-beta
B	0035927	biological_process	RNA import into mitochondrion
B	0035928	biological_process	rRNA import into mitochondrion
B	0042802	molecular_function	identical protein binding
B	0043457	biological_process	regulation of cellular respiration
B	0043631	biological_process	obsolete RNA polyadenylation
B	0045025	cellular_component	mitochondrial degradosome
B	0051260	biological_process	protein homooligomerization
B	0051591	biological_process	response to cAMP
B	0060416	biological_process	response to growth hormone
B	0061014	biological_process	positive regulation of mRNA catabolic process
B	0070207	biological_process	protein homotrimerization
B	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
B	0097222	biological_process	mitochondrial mRNA polyadenylation
B	0097421	biological_process	liver regeneration
B	1905354	cellular_component	exoribonuclease complex
B	2000627	biological_process	positive regulation of miRNA catabolic process
B	2000772	biological_process	regulation of cellular senescence
C	0000175	molecular_function	3'-5'-RNA exonuclease activity
C	0000957	biological_process	mitochondrial RNA catabolic process
C	0000958	biological_process	mitochondrial mRNA catabolic process
C	0000962	biological_process	positive regulation of mitochondrial RNA catabolic process
C	0000964	biological_process	mitochondrial RNA 5'-end processing
C	0000965	biological_process	mitochondrial RNA 3'-end processing
C	0003723	molecular_function	RNA binding
C	0004518	molecular_function	nuclease activity
C	0004527	molecular_function	exonuclease activity
C	0004654	molecular_function	polyribonucleotide nucleotidyltransferase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005758	cellular_component	mitochondrial intermembrane space
C	0005759	cellular_component	mitochondrial matrix
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0005840	cellular_component	ribosome
C	0006396	biological_process	RNA processing
C	0006397	biological_process	mRNA processing
C	0006401	biological_process	RNA catabolic process
C	0006402	biological_process	mRNA catabolic process
C	0007005	biological_process	mitochondrion organization
C	0008266	molecular_function	poly(U) RNA binding
C	0016020	cellular_component	membrane
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0016787	molecular_function	hydrolase activity
C	0034046	molecular_function	poly(G) binding
C	0034599	biological_process	cellular response to oxidative stress
C	0035198	molecular_function	miRNA binding
C	0035458	biological_process	cellular response to interferon-beta
C	0035927	biological_process	RNA import into mitochondrion
C	0035928	biological_process	rRNA import into mitochondrion
C	0042802	molecular_function	identical protein binding
C	0043457	biological_process	regulation of cellular respiration
C	0043631	biological_process	obsolete RNA polyadenylation
C	0045025	cellular_component	mitochondrial degradosome
C	0051260	biological_process	protein homooligomerization
C	0051591	biological_process	response to cAMP
C	0060416	biological_process	response to growth hormone
C	0061014	biological_process	positive regulation of mRNA catabolic process
C	0070207	biological_process	protein homotrimerization
C	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
C	0097222	biological_process	mitochondrial mRNA polyadenylation
C	0097421	biological_process	liver regeneration
C	1905354	cellular_component	exoribonuclease complex
C	2000627	biological_process	positive regulation of miRNA catabolic process
C	2000772	biological_process	regulation of cellular senescence

Functional Information from PROSITE/UniProt

site_id	PS00659
Number of Residues	10
Details	GLYCOSYL_HYDROL_F5 Glycosyl hydrolases family 5 signature. LAVDGVNEPD

Chain	Residue	Details
A	LEU157-ASP166

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	177
Details	Domain: {"description":"KH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00117","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	213
Details	Domain: {"description":"S1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00180","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8K1R3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	9
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8K1R3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)