9KEV

Cryo-EM structure of Mycobacterium tuberculosis transcription activation complex with six PhoP molecules (composite map)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006351	biological_process	DNA-templated transcription
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034062	molecular_function	5'-3' RNA polymerase activity
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006351	biological_process	DNA-templated transcription
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0034062	molecular_function	5'-3' RNA polymerase activity
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006351	biological_process	DNA-templated transcription
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0034062	molecular_function	5'-3' RNA polymerase activity
C	0046677	biological_process	response to antibiotic
D	0000287	molecular_function	magnesium ion binding
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0003677	molecular_function	DNA binding
D	0003899	molecular_function	DNA-directed RNA polymerase activity
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006351	biological_process	DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0034062	molecular_function	5'-3' RNA polymerase activity
D	0046872	molecular_function	metal ion binding
E	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0001000	molecular_function	bacterial-type RNA polymerase core enzyme binding
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0005829	cellular_component	cytosol
E	0006351	biological_process	DNA-templated transcription
E	0006352	biological_process	DNA-templated transcription initiation
E	0009274	cellular_component	peptidoglycan-based cell wall
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0034062	molecular_function	5'-3' RNA polymerase activity
F	0000976	molecular_function	transcription cis-regulatory region binding
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed RNA polymerase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0006352	biological_process	DNA-templated transcription initiation
F	0006355	biological_process	regulation of DNA-templated transcription
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0009415	biological_process	response to water
F	0010468	biological_process	regulation of gene expression
F	0016987	molecular_function	sigma factor activity
F	1903865	cellular_component	sigma factor antagonist complex
F	2000142	biological_process	regulation of DNA-templated transcription initiation
J	0000156	molecular_function	phosphorelay response regulator activity
J	0000160	biological_process	phosphorelay signal transduction system
J	0000976	molecular_function	transcription cis-regulatory region binding
J	0003677	molecular_function	DNA binding
J	0005515	molecular_function	protein binding
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006979	biological_process	response to oxidative stress
J	0009247	biological_process	glycolipid biosynthetic process
J	0010628	biological_process	positive regulation of gene expression
J	0032993	cellular_component	protein-DNA complex
J	0044315	biological_process	protein secretion by the type VII secretion system
J	0045892	biological_process	negative regulation of DNA-templated transcription
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0046872	molecular_function	metal ion binding
J	0046889	biological_process	positive regulation of lipid biosynthetic process
K	0000156	molecular_function	phosphorelay response regulator activity
K	0000160	biological_process	phosphorelay signal transduction system
K	0000976	molecular_function	transcription cis-regulatory region binding
K	0003677	molecular_function	DNA binding
K	0005515	molecular_function	protein binding
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0006355	biological_process	regulation of DNA-templated transcription
K	0006979	biological_process	response to oxidative stress
K	0009247	biological_process	glycolipid biosynthetic process
K	0010628	biological_process	positive regulation of gene expression
K	0032993	cellular_component	protein-DNA complex
K	0044315	biological_process	protein secretion by the type VII secretion system
K	0045892	biological_process	negative regulation of DNA-templated transcription
K	0045893	biological_process	positive regulation of DNA-templated transcription
K	0046872	molecular_function	metal ion binding
K	0046889	biological_process	positive regulation of lipid biosynthetic process
L	0000156	molecular_function	phosphorelay response regulator activity
L	0000160	biological_process	phosphorelay signal transduction system
L	0000976	molecular_function	transcription cis-regulatory region binding
L	0003677	molecular_function	DNA binding
L	0005515	molecular_function	protein binding
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006979	biological_process	response to oxidative stress
L	0009247	biological_process	glycolipid biosynthetic process
L	0010628	biological_process	positive regulation of gene expression
L	0032993	cellular_component	protein-DNA complex
L	0044315	biological_process	protein secretion by the type VII secretion system
L	0045892	biological_process	negative regulation of DNA-templated transcription
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0046872	molecular_function	metal ion binding
L	0046889	biological_process	positive regulation of lipid biosynthetic process
M	0000156	molecular_function	phosphorelay response regulator activity
M	0000160	biological_process	phosphorelay signal transduction system
M	0000976	molecular_function	transcription cis-regulatory region binding
M	0003677	molecular_function	DNA binding
M	0005515	molecular_function	protein binding
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0006355	biological_process	regulation of DNA-templated transcription
M	0006979	biological_process	response to oxidative stress
M	0009247	biological_process	glycolipid biosynthetic process
M	0010628	biological_process	positive regulation of gene expression
M	0032993	cellular_component	protein-DNA complex
M	0044315	biological_process	protein secretion by the type VII secretion system
M	0045892	biological_process	negative regulation of DNA-templated transcription
M	0045893	biological_process	positive regulation of DNA-templated transcription
M	0046872	molecular_function	metal ion binding
M	0046889	biological_process	positive regulation of lipid biosynthetic process
N	0000156	molecular_function	phosphorelay response regulator activity
N	0000160	biological_process	phosphorelay signal transduction system
N	0000976	molecular_function	transcription cis-regulatory region binding
N	0003677	molecular_function	DNA binding
N	0005515	molecular_function	protein binding
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0006355	biological_process	regulation of DNA-templated transcription
N	0006979	biological_process	response to oxidative stress
N	0009247	biological_process	glycolipid biosynthetic process
N	0010628	biological_process	positive regulation of gene expression
N	0032993	cellular_component	protein-DNA complex
N	0044315	biological_process	protein secretion by the type VII secretion system
N	0045892	biological_process	negative regulation of DNA-templated transcription
N	0045893	biological_process	positive regulation of DNA-templated transcription
N	0046872	molecular_function	metal ion binding
N	0046889	biological_process	positive regulation of lipid biosynthetic process
O	0000156	molecular_function	phosphorelay response regulator activity
O	0000160	biological_process	phosphorelay signal transduction system
O	0000976	molecular_function	transcription cis-regulatory region binding
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005829	cellular_component	cytosol
O	0005886	cellular_component	plasma membrane
O	0006355	biological_process	regulation of DNA-templated transcription
O	0006979	biological_process	response to oxidative stress
O	0009247	biological_process	glycolipid biosynthetic process
O	0010628	biological_process	positive regulation of gene expression
O	0032993	cellular_component	protein-DNA complex
O	0044315	biological_process	protein secretion by the type VII secretion system
O	0045892	biological_process	negative regulation of DNA-templated transcription
O	0045893	biological_process	positive regulation of DNA-templated transcription
O	0046872	molecular_function	metal ion binding
O	0046889	biological_process	positive regulation of lipid biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00217
Number of Residues	26
Details	SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. IaGLTlGGddyvtkpFslEevvarlR

Chain	Residue	Details
J	ILE108-ARG133

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site_id	PS00715
Number of Residues	14
Details	SIGMA70_1 Sigma-70 factors family signature 1. DLIQeGnLGLIrAV

Chain	Residue	Details
F	ASP319-VAL332

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site_id	PS00716
Number of Residues	27
Details	SIGMA70_2 Sigma-70 factors family signature 2. TldEIGqvygVTrerIrQIEsktMskL

Chain	Residue	Details
F	THR488-LEU514

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site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LLEANLRL

Chain	Residue	Details
F	LEU295-LEU302

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site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKLAGrHGNKGV

Chain	Residue	Details
C	GLY882-VAL894

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	DNA_BIND: H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963

Chain	Residue	Details
F	LEU489-SER508
D	CYS975
D	CYS978
D	CYS62
D	CYS75
D	CYS78
D	ASP535
D	ASP537
D	ASP539
D	CYS891
D	CYS968

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