9KCP

Cryo-EM structure of ACI-12589-bound alpha-synuclein fibril polymorph 6A6B

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000149	molecular_function	SNARE binding
D	0000287	molecular_function	magnesium ion binding
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0001774	biological_process	microglial cell activation
D	0001921	biological_process	positive regulation of receptor recycling
D	0001963	biological_process	synaptic transmission, dopaminergic
D	0003779	molecular_function	actin binding
D	0004857	molecular_function	enzyme inhibitor activity
D	0004860	molecular_function	protein kinase inhibitor activity
D	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
D	0005504	molecular_function	fatty acid binding
D	0005507	molecular_function	copper ion binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005543	molecular_function	phospholipid binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005640	cellular_component	nuclear outer membrane
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005741	cellular_component	mitochondrial outer membrane
D	0005743	cellular_component	mitochondrial inner membrane
D	0005759	cellular_component	mitochondrial matrix
D	0005764	cellular_component	lysosome
D	0005829	cellular_component	cytosol
D	0005840	cellular_component	ribosome
D	0005856	cellular_component	cytoskeleton
D	0005886	cellular_component	plasma membrane
D	0005938	cellular_component	cell cortex
D	0006749	biological_process	glutathione metabolic process
D	0008017	molecular_function	microtubule binding
D	0008021	cellular_component	synaptic vesicle
D	0008047	molecular_function	enzyme activator activity
D	0008198	molecular_function	ferrous iron binding
D	0008270	molecular_function	zinc ion binding
D	0008289	molecular_function	lipid binding
D	0010040	biological_process	response to iron(II) ion
D	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
D	0014059	biological_process	regulation of dopamine secretion
D	0015629	cellular_component	actin cytoskeleton
D	0015631	molecular_function	tubulin binding
D	0016020	cellular_component	membrane
D	0016079	biological_process	synaptic vesicle exocytosis
D	0016082	biological_process	synaptic vesicle priming
D	0016234	cellular_component	inclusion body
D	0016491	molecular_function	oxidoreductase activity
D	0019894	molecular_function	kinesin binding
D	0019899	molecular_function	enzyme binding
D	0019904	molecular_function	protein domain specific binding
D	0030424	cellular_component	axon
D	0030426	cellular_component	growth cone
D	0030544	molecular_function	Hsp70 protein binding
D	0030659	cellular_component	cytoplasmic vesicle membrane
D	0030672	cellular_component	synaptic vesicle membrane
D	0031092	cellular_component	platelet alpha granule membrane
D	0031115	biological_process	negative regulation of microtubule polymerization
D	0031623	biological_process	receptor internalization
D	0031648	biological_process	protein destabilization
D	0032026	biological_process	response to magnesium ion
D	0032496	biological_process	response to lipopolysaccharide
D	0032991	cellular_component	protein-containing complex
D	0034341	biological_process	response to type II interferon
D	0034599	biological_process	cellular response to oxidative stress
D	0035493	biological_process	SNARE complex assembly
D	0035543	biological_process	positive regulation of SNARE complex assembly
D	0042220	biological_process	response to cocaine
D	0042393	molecular_function	histone binding
D	0042416	biological_process	dopamine biosynthetic process
D	0042802	molecular_function	identical protein binding
D	0043014	molecular_function	alpha-tubulin binding
D	0043025	cellular_component	neuronal cell body
D	0043065	biological_process	positive regulation of apoptotic process
D	0043066	biological_process	negative regulation of apoptotic process
D	0043195	cellular_component	terminal bouton
D	0043274	molecular_function	phospholipase binding
D	0043524	biological_process	negative regulation of neuron apoptotic process
D	0043679	cellular_component	axon terminus
D	0044344	biological_process	cellular response to fibroblast growth factor stimulus
D	0045202	cellular_component	synapse
D	0045807	biological_process	positive regulation of endocytosis
D	0045920	biological_process	negative regulation of exocytosis
D	0045921	biological_process	positive regulation of exocytosis
D	0045963	biological_process	negative regulation of dopamine metabolic process
D	0046872	molecular_function	metal ion binding
D	0048148	biological_process	behavioral response to cocaine
D	0048156	molecular_function	tau protein binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0048487	molecular_function	beta-tubulin binding
D	0048488	biological_process	synaptic vesicle endocytosis
D	0048489	biological_process	synaptic vesicle transport
D	0050729	biological_process	positive regulation of inflammatory response
D	0050808	biological_process	synapse organization
D	0051219	molecular_function	phosphoprotein binding
D	0051259	biological_process	protein complex oligomerization
D	0051262	biological_process	protein tetramerization
D	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
D	0051583	biological_process	dopamine uptake involved in synaptic transmission
D	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
D	0051612	biological_process	negative regulation of serotonin uptake
D	0051621	biological_process	regulation of norepinephrine uptake
D	0051622	biological_process	negative regulation of norepinephrine uptake
D	0055074	biological_process	calcium ion homeostasis
D	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
D	0060961	molecular_function	phospholipase D inhibitor activity
D	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
D	0070507	biological_process	regulation of microtubule cytoskeleton organization
D	0070555	biological_process	response to interleukin-1
D	0070840	molecular_function	dynein complex binding
D	0071280	biological_process	cellular response to copper ion
D	0071872	biological_process	cellular response to epinephrine stimulus
D	0097413	cellular_component	Lewy body
D	0097435	biological_process	supramolecular fiber organization
D	0098793	cellular_component	presynapse
D	0099512	cellular_component	supramolecular fiber
D	0140311	molecular_function	protein sequestering activity
D	0141108	molecular_function	transporter regulator activity
D	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
D	1903136	molecular_function	cuprous ion binding
D	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
D	1903421	biological_process	regulation of synaptic vesicle recycling
D	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
D	1904307	biological_process	response to desipramine
D	1904377	biological_process	positive regulation of protein localization to cell periphery
D	1904715	biological_process	negative regulation of chaperone-mediated autophagy
D	1905606	biological_process	regulation of presynapse assembly
D	1990000	biological_process	amyloid fibril formation
D	2000377	biological_process	regulation of reactive oxygen species metabolic process
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000149	molecular_function	SNARE binding
E	0000287	molecular_function	magnesium ion binding
E	0000976	molecular_function	transcription cis-regulatory region binding
E	0001774	biological_process	microglial cell activation
E	0001921	biological_process	positive regulation of receptor recycling
E	0001963	biological_process	synaptic transmission, dopaminergic
E	0003779	molecular_function	actin binding
E	0004857	molecular_function	enzyme inhibitor activity
E	0004860	molecular_function	protein kinase inhibitor activity
E	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
E	0005504	molecular_function	fatty acid binding
E	0005507	molecular_function	copper ion binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005543	molecular_function	phospholipid binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005640	cellular_component	nuclear outer membrane
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005741	cellular_component	mitochondrial outer membrane
E	0005743	cellular_component	mitochondrial inner membrane
E	0005759	cellular_component	mitochondrial matrix
E	0005764	cellular_component	lysosome
E	0005829	cellular_component	cytosol
E	0005840	cellular_component	ribosome
E	0005856	cellular_component	cytoskeleton
E	0005886	cellular_component	plasma membrane
E	0005938	cellular_component	cell cortex
E	0006749	biological_process	glutathione metabolic process
E	0008017	molecular_function	microtubule binding
E	0008021	cellular_component	synaptic vesicle
E	0008047	molecular_function	enzyme activator activity
E	0008198	molecular_function	ferrous iron binding
E	0008270	molecular_function	zinc ion binding
E	0008289	molecular_function	lipid binding
E	0010040	biological_process	response to iron(II) ion
E	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
E	0014059	biological_process	regulation of dopamine secretion
E	0015629	cellular_component	actin cytoskeleton
E	0015631	molecular_function	tubulin binding
E	0016020	cellular_component	membrane
E	0016079	biological_process	synaptic vesicle exocytosis
E	0016082	biological_process	synaptic vesicle priming
E	0016234	cellular_component	inclusion body
E	0016491	molecular_function	oxidoreductase activity
E	0019894	molecular_function	kinesin binding
E	0019899	molecular_function	enzyme binding
E	0019904	molecular_function	protein domain specific binding
E	0030424	cellular_component	axon
E	0030426	cellular_component	growth cone
E	0030544	molecular_function	Hsp70 protein binding
E	0030659	cellular_component	cytoplasmic vesicle membrane
E	0030672	cellular_component	synaptic vesicle membrane
E	0031092	cellular_component	platelet alpha granule membrane
E	0031115	biological_process	negative regulation of microtubule polymerization
E	0031623	biological_process	receptor internalization
E	0031648	biological_process	protein destabilization
E	0032026	biological_process	response to magnesium ion
E	0032496	biological_process	response to lipopolysaccharide
E	0032991	cellular_component	protein-containing complex
E	0034341	biological_process	response to type II interferon
E	0034599	biological_process	cellular response to oxidative stress
E	0035493	biological_process	SNARE complex assembly
E	0035543	biological_process	positive regulation of SNARE complex assembly
E	0042220	biological_process	response to cocaine
E	0042393	molecular_function	histone binding
E	0042416	biological_process	dopamine biosynthetic process
E	0042802	molecular_function	identical protein binding
E	0043014	molecular_function	alpha-tubulin binding
E	0043025	cellular_component	neuronal cell body
E	0043065	biological_process	positive regulation of apoptotic process
E	0043066	biological_process	negative regulation of apoptotic process
E	0043195	cellular_component	terminal bouton
E	0043274	molecular_function	phospholipase binding
E	0043524	biological_process	negative regulation of neuron apoptotic process
E	0043679	cellular_component	axon terminus
E	0044344	biological_process	cellular response to fibroblast growth factor stimulus
E	0045202	cellular_component	synapse
E	0045807	biological_process	positive regulation of endocytosis
E	0045920	biological_process	negative regulation of exocytosis
E	0045921	biological_process	positive regulation of exocytosis
E	0045963	biological_process	negative regulation of dopamine metabolic process
E	0046872	molecular_function	metal ion binding
E	0048148	biological_process	behavioral response to cocaine
E	0048156	molecular_function	tau protein binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0048487	molecular_function	beta-tubulin binding
E	0048488	biological_process	synaptic vesicle endocytosis
E	0048489	biological_process	synaptic vesicle transport
E	0050729	biological_process	positive regulation of inflammatory response
E	0050808	biological_process	synapse organization
E	0051219	molecular_function	phosphoprotein binding
E	0051259	biological_process	protein complex oligomerization
E	0051262	biological_process	protein tetramerization
E	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
E	0051583	biological_process	dopamine uptake involved in synaptic transmission
E	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
E	0051612	biological_process	negative regulation of serotonin uptake
E	0051621	biological_process	regulation of norepinephrine uptake
E	0051622	biological_process	negative regulation of norepinephrine uptake
E	0055074	biological_process	calcium ion homeostasis
E	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
E	0060961	molecular_function	phospholipase D inhibitor activity
E	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
E	0070507	biological_process	regulation of microtubule cytoskeleton organization
E	0070555	biological_process	response to interleukin-1
E	0070840	molecular_function	dynein complex binding
E	0071280	biological_process	cellular response to copper ion
E	0071872	biological_process	cellular response to epinephrine stimulus
E	0097413	cellular_component	Lewy body
E	0097435	biological_process	supramolecular fiber organization
E	0098793	cellular_component	presynapse
E	0099512	cellular_component	supramolecular fiber
E	0140311	molecular_function	protein sequestering activity
E	0141108	molecular_function	transporter regulator activity
E	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
E	1903136	molecular_function	cuprous ion binding
E	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
E	1903421	biological_process	regulation of synaptic vesicle recycling
E	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
E	1904307	biological_process	response to desipramine
E	1904377	biological_process	positive regulation of protein localization to cell periphery
E	1904715	biological_process	negative regulation of chaperone-mediated autophagy
E	1905606	biological_process	regulation of presynapse assembly
E	1990000	biological_process	amyloid fibril formation
E	2000377	biological_process	regulation of reactive oxygen species metabolic process
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000149	molecular_function	SNARE binding
F	0000287	molecular_function	magnesium ion binding
F	0000976	molecular_function	transcription cis-regulatory region binding
F	0001774	biological_process	microglial cell activation
F	0001921	biological_process	positive regulation of receptor recycling
F	0001963	biological_process	synaptic transmission, dopaminergic
F	0003779	molecular_function	actin binding
F	0004857	molecular_function	enzyme inhibitor activity
F	0004860	molecular_function	protein kinase inhibitor activity
F	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
F	0005504	molecular_function	fatty acid binding
F	0005507	molecular_function	copper ion binding
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005543	molecular_function	phospholipid binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005640	cellular_component	nuclear outer membrane
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005741	cellular_component	mitochondrial outer membrane
F	0005743	cellular_component	mitochondrial inner membrane
F	0005759	cellular_component	mitochondrial matrix
F	0005764	cellular_component	lysosome
F	0005829	cellular_component	cytosol
F	0005840	cellular_component	ribosome
F	0005856	cellular_component	cytoskeleton
F	0005886	cellular_component	plasma membrane
F	0005938	cellular_component	cell cortex
F	0006749	biological_process	glutathione metabolic process
F	0008017	molecular_function	microtubule binding
F	0008021	cellular_component	synaptic vesicle
F	0008047	molecular_function	enzyme activator activity
F	0008198	molecular_function	ferrous iron binding
F	0008270	molecular_function	zinc ion binding
F	0008289	molecular_function	lipid binding
F	0010040	biological_process	response to iron(II) ion
F	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
F	0014059	biological_process	regulation of dopamine secretion
F	0015629	cellular_component	actin cytoskeleton
F	0015631	molecular_function	tubulin binding
F	0016020	cellular_component	membrane
F	0016079	biological_process	synaptic vesicle exocytosis
F	0016082	biological_process	synaptic vesicle priming
F	0016234	cellular_component	inclusion body
F	0016491	molecular_function	oxidoreductase activity
F	0019894	molecular_function	kinesin binding
F	0019899	molecular_function	enzyme binding
F	0019904	molecular_function	protein domain specific binding
F	0030424	cellular_component	axon
F	0030426	cellular_component	growth cone
F	0030544	molecular_function	Hsp70 protein binding
F	0030659	cellular_component	cytoplasmic vesicle membrane
F	0030672	cellular_component	synaptic vesicle membrane
F	0031092	cellular_component	platelet alpha granule membrane
F	0031115	biological_process	negative regulation of microtubule polymerization
F	0031623	biological_process	receptor internalization
F	0031648	biological_process	protein destabilization
F	0032026	biological_process	response to magnesium ion
F	0032496	biological_process	response to lipopolysaccharide
F	0032991	cellular_component	protein-containing complex
F	0034341	biological_process	response to type II interferon
F	0034599	biological_process	cellular response to oxidative stress
F	0035493	biological_process	SNARE complex assembly
F	0035543	biological_process	positive regulation of SNARE complex assembly
F	0042220	biological_process	response to cocaine
F	0042393	molecular_function	histone binding
F	0042416	biological_process	dopamine biosynthetic process
F	0042802	molecular_function	identical protein binding
F	0043014	molecular_function	alpha-tubulin binding
F	0043025	cellular_component	neuronal cell body
F	0043065	biological_process	positive regulation of apoptotic process
F	0043066	biological_process	negative regulation of apoptotic process
F	0043195	cellular_component	terminal bouton
F	0043274	molecular_function	phospholipase binding
F	0043524	biological_process	negative regulation of neuron apoptotic process
F	0043679	cellular_component	axon terminus
F	0044344	biological_process	cellular response to fibroblast growth factor stimulus
F	0045202	cellular_component	synapse
F	0045807	biological_process	positive regulation of endocytosis
F	0045920	biological_process	negative regulation of exocytosis
F	0045921	biological_process	positive regulation of exocytosis
F	0045963	biological_process	negative regulation of dopamine metabolic process
F	0046872	molecular_function	metal ion binding
F	0048148	biological_process	behavioral response to cocaine
F	0048156	molecular_function	tau protein binding
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0048487	molecular_function	beta-tubulin binding
F	0048488	biological_process	synaptic vesicle endocytosis
F	0048489	biological_process	synaptic vesicle transport
F	0050729	biological_process	positive regulation of inflammatory response
F	0050808	biological_process	synapse organization
F	0051219	molecular_function	phosphoprotein binding
F	0051259	biological_process	protein complex oligomerization
F	0051262	biological_process	protein tetramerization
F	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
F	0051583	biological_process	dopamine uptake involved in synaptic transmission
F	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
F	0051612	biological_process	negative regulation of serotonin uptake
F	0051621	biological_process	regulation of norepinephrine uptake
F	0051622	biological_process	negative regulation of norepinephrine uptake
F	0055074	biological_process	calcium ion homeostasis
F	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
F	0060961	molecular_function	phospholipase D inhibitor activity
F	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
F	0070507	biological_process	regulation of microtubule cytoskeleton organization
F	0070555	biological_process	response to interleukin-1
F	0070840	molecular_function	dynein complex binding
F	0071280	biological_process	cellular response to copper ion
F	0071872	biological_process	cellular response to epinephrine stimulus
F	0097413	cellular_component	Lewy body
F	0097435	biological_process	supramolecular fiber organization
F	0098793	cellular_component	presynapse
F	0099512	cellular_component	supramolecular fiber
F	0140311	molecular_function	protein sequestering activity
F	0141108	molecular_function	transporter regulator activity
F	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
F	1903136	molecular_function	cuprous ion binding
F	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
F	1903421	biological_process	regulation of synaptic vesicle recycling
F	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
F	1904307	biological_process	response to desipramine
F	1904377	biological_process	positive regulation of protein localization to cell periphery
F	1904715	biological_process	negative regulation of chaperone-mediated autophagy
F	1905606	biological_process	regulation of presynapse assembly
F	1990000	biological_process	amyloid fibril formation
F	2000377	biological_process	regulation of reactive oxygen species metabolic process
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000149	molecular_function	SNARE binding
G	0000287	molecular_function	magnesium ion binding
G	0000976	molecular_function	transcription cis-regulatory region binding
G	0001774	biological_process	microglial cell activation
G	0001921	biological_process	positive regulation of receptor recycling
G	0001963	biological_process	synaptic transmission, dopaminergic
G	0003779	molecular_function	actin binding
G	0004857	molecular_function	enzyme inhibitor activity
G	0004860	molecular_function	protein kinase inhibitor activity
G	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
G	0005504	molecular_function	fatty acid binding
G	0005507	molecular_function	copper ion binding
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005543	molecular_function	phospholipid binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005640	cellular_component	nuclear outer membrane
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005741	cellular_component	mitochondrial outer membrane
G	0005743	cellular_component	mitochondrial inner membrane
G	0005759	cellular_component	mitochondrial matrix
G	0005764	cellular_component	lysosome
G	0005829	cellular_component	cytosol
G	0005840	cellular_component	ribosome
G	0005856	cellular_component	cytoskeleton
G	0005886	cellular_component	plasma membrane
G	0005938	cellular_component	cell cortex
G	0006749	biological_process	glutathione metabolic process
G	0008017	molecular_function	microtubule binding
G	0008021	cellular_component	synaptic vesicle
G	0008047	molecular_function	enzyme activator activity
G	0008198	molecular_function	ferrous iron binding
G	0008270	molecular_function	zinc ion binding
G	0008289	molecular_function	lipid binding
G	0010040	biological_process	response to iron(II) ion
G	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
G	0014059	biological_process	regulation of dopamine secretion
G	0015629	cellular_component	actin cytoskeleton
G	0015631	molecular_function	tubulin binding
G	0016020	cellular_component	membrane
G	0016079	biological_process	synaptic vesicle exocytosis
G	0016082	biological_process	synaptic vesicle priming
G	0016234	cellular_component	inclusion body
G	0016491	molecular_function	oxidoreductase activity
G	0019894	molecular_function	kinesin binding
G	0019899	molecular_function	enzyme binding
G	0019904	molecular_function	protein domain specific binding
G	0030424	cellular_component	axon
G	0030426	cellular_component	growth cone
G	0030544	molecular_function	Hsp70 protein binding
G	0030659	cellular_component	cytoplasmic vesicle membrane
G	0030672	cellular_component	synaptic vesicle membrane
G	0031092	cellular_component	platelet alpha granule membrane
G	0031115	biological_process	negative regulation of microtubule polymerization
G	0031623	biological_process	receptor internalization
G	0031648	biological_process	protein destabilization
G	0032026	biological_process	response to magnesium ion
G	0032496	biological_process	response to lipopolysaccharide
G	0032991	cellular_component	protein-containing complex
G	0034341	biological_process	response to type II interferon
G	0034599	biological_process	cellular response to oxidative stress
G	0035493	biological_process	SNARE complex assembly
G	0035543	biological_process	positive regulation of SNARE complex assembly
G	0042220	biological_process	response to cocaine
G	0042393	molecular_function	histone binding
G	0042416	biological_process	dopamine biosynthetic process
G	0042802	molecular_function	identical protein binding
G	0043014	molecular_function	alpha-tubulin binding
G	0043025	cellular_component	neuronal cell body
G	0043065	biological_process	positive regulation of apoptotic process
G	0043066	biological_process	negative regulation of apoptotic process
G	0043195	cellular_component	terminal bouton
G	0043274	molecular_function	phospholipase binding
G	0043524	biological_process	negative regulation of neuron apoptotic process
G	0043679	cellular_component	axon terminus
G	0044344	biological_process	cellular response to fibroblast growth factor stimulus
G	0045202	cellular_component	synapse
G	0045807	biological_process	positive regulation of endocytosis
G	0045920	biological_process	negative regulation of exocytosis
G	0045921	biological_process	positive regulation of exocytosis
G	0045963	biological_process	negative regulation of dopamine metabolic process
G	0046872	molecular_function	metal ion binding
G	0048148	biological_process	behavioral response to cocaine
G	0048156	molecular_function	tau protein binding
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0048487	molecular_function	beta-tubulin binding
G	0048488	biological_process	synaptic vesicle endocytosis
G	0048489	biological_process	synaptic vesicle transport
G	0050729	biological_process	positive regulation of inflammatory response
G	0050808	biological_process	synapse organization
G	0051219	molecular_function	phosphoprotein binding
G	0051259	biological_process	protein complex oligomerization
G	0051262	biological_process	protein tetramerization
G	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
G	0051583	biological_process	dopamine uptake involved in synaptic transmission
G	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
G	0051612	biological_process	negative regulation of serotonin uptake
G	0051621	biological_process	regulation of norepinephrine uptake
G	0051622	biological_process	negative regulation of norepinephrine uptake
G	0055074	biological_process	calcium ion homeostasis
G	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
G	0060961	molecular_function	phospholipase D inhibitor activity
G	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
G	0070507	biological_process	regulation of microtubule cytoskeleton organization
G	0070555	biological_process	response to interleukin-1
G	0070840	molecular_function	dynein complex binding
G	0071280	biological_process	cellular response to copper ion
G	0071872	biological_process	cellular response to epinephrine stimulus
G	0097413	cellular_component	Lewy body
G	0097435	biological_process	supramolecular fiber organization
G	0098793	cellular_component	presynapse
G	0099512	cellular_component	supramolecular fiber
G	0140311	molecular_function	protein sequestering activity
G	0141108	molecular_function	transporter regulator activity
G	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
G	1903136	molecular_function	cuprous ion binding
G	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
G	1903421	biological_process	regulation of synaptic vesicle recycling
G	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
G	1904307	biological_process	response to desipramine
G	1904377	biological_process	positive regulation of protein localization to cell periphery
G	1904715	biological_process	negative regulation of chaperone-mediated autophagy
G	1905606	biological_process	regulation of presynapse assembly
G	1990000	biological_process	amyloid fibril formation
G	2000377	biological_process	regulation of reactive oxygen species metabolic process
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0000149	molecular_function	SNARE binding
H	0000287	molecular_function	magnesium ion binding
H	0000976	molecular_function	transcription cis-regulatory region binding
H	0001774	biological_process	microglial cell activation
H	0001921	biological_process	positive regulation of receptor recycling
H	0001963	biological_process	synaptic transmission, dopaminergic
H	0003779	molecular_function	actin binding
H	0004857	molecular_function	enzyme inhibitor activity
H	0004860	molecular_function	protein kinase inhibitor activity
H	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
H	0005504	molecular_function	fatty acid binding
H	0005507	molecular_function	copper ion binding
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005543	molecular_function	phospholipid binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005640	cellular_component	nuclear outer membrane
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005741	cellular_component	mitochondrial outer membrane
H	0005743	cellular_component	mitochondrial inner membrane
H	0005759	cellular_component	mitochondrial matrix
H	0005764	cellular_component	lysosome
H	0005829	cellular_component	cytosol
H	0005840	cellular_component	ribosome
H	0005856	cellular_component	cytoskeleton
H	0005886	cellular_component	plasma membrane
H	0005938	cellular_component	cell cortex
H	0006749	biological_process	glutathione metabolic process
H	0008017	molecular_function	microtubule binding
H	0008021	cellular_component	synaptic vesicle
H	0008047	molecular_function	enzyme activator activity
H	0008198	molecular_function	ferrous iron binding
H	0008270	molecular_function	zinc ion binding
H	0008289	molecular_function	lipid binding
H	0010040	biological_process	response to iron(II) ion
H	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
H	0014059	biological_process	regulation of dopamine secretion
H	0015629	cellular_component	actin cytoskeleton
H	0015631	molecular_function	tubulin binding
H	0016020	cellular_component	membrane
H	0016079	biological_process	synaptic vesicle exocytosis
H	0016082	biological_process	synaptic vesicle priming
H	0016234	cellular_component	inclusion body
H	0016491	molecular_function	oxidoreductase activity
H	0019894	molecular_function	kinesin binding
H	0019899	molecular_function	enzyme binding
H	0019904	molecular_function	protein domain specific binding
H	0030424	cellular_component	axon
H	0030426	cellular_component	growth cone
H	0030544	molecular_function	Hsp70 protein binding
H	0030659	cellular_component	cytoplasmic vesicle membrane
H	0030672	cellular_component	synaptic vesicle membrane
H	0031092	cellular_component	platelet alpha granule membrane
H	0031115	biological_process	negative regulation of microtubule polymerization
H	0031623	biological_process	receptor internalization
H	0031648	biological_process	protein destabilization
H	0032026	biological_process	response to magnesium ion
H	0032496	biological_process	response to lipopolysaccharide
H	0032991	cellular_component	protein-containing complex
H	0034341	biological_process	response to type II interferon
H	0034599	biological_process	cellular response to oxidative stress
H	0035493	biological_process	SNARE complex assembly
H	0035543	biological_process	positive regulation of SNARE complex assembly
H	0042220	biological_process	response to cocaine
H	0042393	molecular_function	histone binding
H	0042416	biological_process	dopamine biosynthetic process
H	0042802	molecular_function	identical protein binding
H	0043014	molecular_function	alpha-tubulin binding
H	0043025	cellular_component	neuronal cell body
H	0043065	biological_process	positive regulation of apoptotic process
H	0043066	biological_process	negative regulation of apoptotic process
H	0043195	cellular_component	terminal bouton
H	0043274	molecular_function	phospholipase binding
H	0043524	biological_process	negative regulation of neuron apoptotic process
H	0043679	cellular_component	axon terminus
H	0044344	biological_process	cellular response to fibroblast growth factor stimulus
H	0045202	cellular_component	synapse
H	0045807	biological_process	positive regulation of endocytosis
H	0045920	biological_process	negative regulation of exocytosis
H	0045921	biological_process	positive regulation of exocytosis
H	0045963	biological_process	negative regulation of dopamine metabolic process
H	0046872	molecular_function	metal ion binding
H	0048148	biological_process	behavioral response to cocaine
H	0048156	molecular_function	tau protein binding
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0048487	molecular_function	beta-tubulin binding
H	0048488	biological_process	synaptic vesicle endocytosis
H	0048489	biological_process	synaptic vesicle transport
H	0050729	biological_process	positive regulation of inflammatory response
H	0050808	biological_process	synapse organization
H	0051219	molecular_function	phosphoprotein binding
H	0051259	biological_process	protein complex oligomerization
H	0051262	biological_process	protein tetramerization
H	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
H	0051583	biological_process	dopamine uptake involved in synaptic transmission
H	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
H	0051612	biological_process	negative regulation of serotonin uptake
H	0051621	biological_process	regulation of norepinephrine uptake
H	0051622	biological_process	negative regulation of norepinephrine uptake
H	0055074	biological_process	calcium ion homeostasis
H	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
H	0060961	molecular_function	phospholipase D inhibitor activity
H	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
H	0070507	biological_process	regulation of microtubule cytoskeleton organization
H	0070555	biological_process	response to interleukin-1
H	0070840	molecular_function	dynein complex binding
H	0071280	biological_process	cellular response to copper ion
H	0071872	biological_process	cellular response to epinephrine stimulus
H	0097413	cellular_component	Lewy body
H	0097435	biological_process	supramolecular fiber organization
H	0098793	cellular_component	presynapse
H	0099512	cellular_component	supramolecular fiber
H	0140311	molecular_function	protein sequestering activity
H	0141108	molecular_function	transporter regulator activity
H	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
H	1903136	molecular_function	cuprous ion binding
H	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
H	1903421	biological_process	regulation of synaptic vesicle recycling
H	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
H	1904307	biological_process	response to desipramine
H	1904377	biological_process	positive regulation of protein localization to cell periphery
H	1904715	biological_process	negative regulation of chaperone-mediated autophagy
H	1905606	biological_process	regulation of presynapse assembly
H	1990000	biological_process	amyloid fibril formation
H	2000377	biological_process	regulation of reactive oxygen species metabolic process
I	0000122	biological_process	negative regulation of transcription by RNA polymerase II
I	0000149	molecular_function	SNARE binding
I	0000287	molecular_function	magnesium ion binding
I	0000976	molecular_function	transcription cis-regulatory region binding
I	0001774	biological_process	microglial cell activation
I	0001921	biological_process	positive regulation of receptor recycling
I	0001963	biological_process	synaptic transmission, dopaminergic
I	0003779	molecular_function	actin binding
I	0004857	molecular_function	enzyme inhibitor activity
I	0004860	molecular_function	protein kinase inhibitor activity
I	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
I	0005504	molecular_function	fatty acid binding
I	0005507	molecular_function	copper ion binding
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005543	molecular_function	phospholipid binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005640	cellular_component	nuclear outer membrane
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005741	cellular_component	mitochondrial outer membrane
I	0005743	cellular_component	mitochondrial inner membrane
I	0005759	cellular_component	mitochondrial matrix
I	0005764	cellular_component	lysosome
I	0005829	cellular_component	cytosol
I	0005840	cellular_component	ribosome
I	0005856	cellular_component	cytoskeleton
I	0005886	cellular_component	plasma membrane
I	0005938	cellular_component	cell cortex
I	0006749	biological_process	glutathione metabolic process
I	0008017	molecular_function	microtubule binding
I	0008021	cellular_component	synaptic vesicle
I	0008047	molecular_function	enzyme activator activity
I	0008198	molecular_function	ferrous iron binding
I	0008270	molecular_function	zinc ion binding
I	0008289	molecular_function	lipid binding
I	0010040	biological_process	response to iron(II) ion
I	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
I	0014059	biological_process	regulation of dopamine secretion
I	0015629	cellular_component	actin cytoskeleton
I	0015631	molecular_function	tubulin binding
I	0016020	cellular_component	membrane
I	0016079	biological_process	synaptic vesicle exocytosis
I	0016082	biological_process	synaptic vesicle priming
I	0016234	cellular_component	inclusion body
I	0016491	molecular_function	oxidoreductase activity
I	0019894	molecular_function	kinesin binding
I	0019899	molecular_function	enzyme binding
I	0019904	molecular_function	protein domain specific binding
I	0030424	cellular_component	axon
I	0030426	cellular_component	growth cone
I	0030544	molecular_function	Hsp70 protein binding
I	0030659	cellular_component	cytoplasmic vesicle membrane
I	0030672	cellular_component	synaptic vesicle membrane
I	0031092	cellular_component	platelet alpha granule membrane
I	0031115	biological_process	negative regulation of microtubule polymerization
I	0031623	biological_process	receptor internalization
I	0031648	biological_process	protein destabilization
I	0032026	biological_process	response to magnesium ion
I	0032496	biological_process	response to lipopolysaccharide
I	0032991	cellular_component	protein-containing complex
I	0034341	biological_process	response to type II interferon
I	0034599	biological_process	cellular response to oxidative stress
I	0035493	biological_process	SNARE complex assembly
I	0035543	biological_process	positive regulation of SNARE complex assembly
I	0042220	biological_process	response to cocaine
I	0042393	molecular_function	histone binding
I	0042416	biological_process	dopamine biosynthetic process
I	0042802	molecular_function	identical protein binding
I	0043014	molecular_function	alpha-tubulin binding
I	0043025	cellular_component	neuronal cell body
I	0043065	biological_process	positive regulation of apoptotic process
I	0043066	biological_process	negative regulation of apoptotic process
I	0043195	cellular_component	terminal bouton
I	0043274	molecular_function	phospholipase binding
I	0043524	biological_process	negative regulation of neuron apoptotic process
I	0043679	cellular_component	axon terminus
I	0044344	biological_process	cellular response to fibroblast growth factor stimulus
I	0045202	cellular_component	synapse
I	0045807	biological_process	positive regulation of endocytosis
I	0045920	biological_process	negative regulation of exocytosis
I	0045921	biological_process	positive regulation of exocytosis
I	0045963	biological_process	negative regulation of dopamine metabolic process
I	0046872	molecular_function	metal ion binding
I	0048148	biological_process	behavioral response to cocaine
I	0048156	molecular_function	tau protein binding
I	0048471	cellular_component	perinuclear region of cytoplasm
I	0048487	molecular_function	beta-tubulin binding
I	0048488	biological_process	synaptic vesicle endocytosis
I	0048489	biological_process	synaptic vesicle transport
I	0050729	biological_process	positive regulation of inflammatory response
I	0050808	biological_process	synapse organization
I	0051219	molecular_function	phosphoprotein binding
I	0051259	biological_process	protein complex oligomerization
I	0051262	biological_process	protein tetramerization
I	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
I	0051583	biological_process	dopamine uptake involved in synaptic transmission
I	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
I	0051612	biological_process	negative regulation of serotonin uptake
I	0051621	biological_process	regulation of norepinephrine uptake
I	0051622	biological_process	negative regulation of norepinephrine uptake
I	0055074	biological_process	calcium ion homeostasis
I	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
I	0060961	molecular_function	phospholipase D inhibitor activity
I	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
I	0070507	biological_process	regulation of microtubule cytoskeleton organization
I	0070555	biological_process	response to interleukin-1
I	0070840	molecular_function	dynein complex binding
I	0071280	biological_process	cellular response to copper ion
I	0071872	biological_process	cellular response to epinephrine stimulus
I	0097413	cellular_component	Lewy body
I	0097435	biological_process	supramolecular fiber organization
I	0098793	cellular_component	presynapse
I	0099512	cellular_component	supramolecular fiber
I	0140311	molecular_function	protein sequestering activity
I	0141108	molecular_function	transporter regulator activity
I	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
I	1903136	molecular_function	cuprous ion binding
I	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
I	1903421	biological_process	regulation of synaptic vesicle recycling
I	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
I	1904307	biological_process	response to desipramine
I	1904377	biological_process	positive regulation of protein localization to cell periphery
I	1904715	biological_process	negative regulation of chaperone-mediated autophagy
I	1905606	biological_process	regulation of presynapse assembly
I	1990000	biological_process	amyloid fibril formation
I	2000377	biological_process	regulation of reactive oxygen species metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	Repeat: {"description":"3; approximate"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	60
Details	Repeat: {"description":"4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"10617630","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---