9KBX

CryoEM structure of F-actin bound with GAS2-CH3 domain.

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0001725	cellular_component	stress fiber
H	0003785	molecular_function	actin monomer binding
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005523	molecular_function	tropomyosin binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005865	cellular_component	striated muscle thin filament
H	0005884	cellular_component	actin filament
H	0010628	biological_process	positive regulation of gene expression
H	0016787	molecular_function	hydrolase activity
H	0019904	molecular_function	protein domain specific binding
H	0030027	cellular_component	lamellipodium
H	0030041	biological_process	actin filament polymerization
H	0030175	cellular_component	filopodium
H	0030240	biological_process	skeletal muscle thin filament assembly
H	0031013	molecular_function	troponin I binding
H	0031432	molecular_function	titin binding
H	0031941	cellular_component	filamentous actin
H	0032036	molecular_function	myosin heavy chain binding
H	0032432	cellular_component	actin filament bundle
H	0042802	molecular_function	identical protein binding
H	0044297	cellular_component	cell body
H	0048306	molecular_function	calcium-dependent protein binding
H	0048741	biological_process	skeletal muscle fiber development
H	0051017	biological_process	actin filament bundle assembly
H	0090131	biological_process	mesenchyme migration
H	0098723	cellular_component	skeletal muscle myofibril
H	0140660	molecular_function	cytoskeletal motor activator activity
J	0000166	molecular_function	nucleotide binding
J	0000287	molecular_function	magnesium ion binding
J	0001725	cellular_component	stress fiber
J	0003785	molecular_function	actin monomer binding
J	0005509	molecular_function	calcium ion binding
J	0005515	molecular_function	protein binding
J	0005523	molecular_function	tropomyosin binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005865	cellular_component	striated muscle thin filament
J	0005884	cellular_component	actin filament
J	0010628	biological_process	positive regulation of gene expression
J	0016787	molecular_function	hydrolase activity
J	0019904	molecular_function	protein domain specific binding
J	0030027	cellular_component	lamellipodium
J	0030041	biological_process	actin filament polymerization
J	0030175	cellular_component	filopodium
J	0030240	biological_process	skeletal muscle thin filament assembly
J	0031013	molecular_function	troponin I binding
J	0031432	molecular_function	titin binding
J	0031941	cellular_component	filamentous actin
J	0032036	molecular_function	myosin heavy chain binding
J	0032432	cellular_component	actin filament bundle
J	0042802	molecular_function	identical protein binding
J	0044297	cellular_component	cell body
J	0048306	molecular_function	calcium-dependent protein binding
J	0048741	biological_process	skeletal muscle fiber development
J	0051017	biological_process	actin filament bundle assembly
J	0090131	biological_process	mesenchyme migration
J	0098723	cellular_component	skeletal muscle myofibril
J	0140660	molecular_function	cytoskeletal motor activator activity
K	0000166	molecular_function	nucleotide binding
K	0000287	molecular_function	magnesium ion binding
K	0001725	cellular_component	stress fiber
K	0003785	molecular_function	actin monomer binding
K	0005509	molecular_function	calcium ion binding
K	0005515	molecular_function	protein binding
K	0005523	molecular_function	tropomyosin binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005865	cellular_component	striated muscle thin filament
K	0005884	cellular_component	actin filament
K	0010628	biological_process	positive regulation of gene expression
K	0016787	molecular_function	hydrolase activity
K	0019904	molecular_function	protein domain specific binding
K	0030027	cellular_component	lamellipodium
K	0030041	biological_process	actin filament polymerization
K	0030175	cellular_component	filopodium
K	0030240	biological_process	skeletal muscle thin filament assembly
K	0031013	molecular_function	troponin I binding
K	0031432	molecular_function	titin binding
K	0031941	cellular_component	filamentous actin
K	0032036	molecular_function	myosin heavy chain binding
K	0032432	cellular_component	actin filament bundle
K	0042802	molecular_function	identical protein binding
K	0044297	cellular_component	cell body
K	0048306	molecular_function	calcium-dependent protein binding
K	0048741	biological_process	skeletal muscle fiber development
K	0051017	biological_process	actin filament bundle assembly
K	0090131	biological_process	mesenchyme migration
K	0098723	cellular_component	skeletal muscle myofibril
K	0140660	molecular_function	cytoskeletal motor activator activity
L	0000166	molecular_function	nucleotide binding
L	0000287	molecular_function	magnesium ion binding
L	0001725	cellular_component	stress fiber
L	0003785	molecular_function	actin monomer binding
L	0005509	molecular_function	calcium ion binding
L	0005515	molecular_function	protein binding
L	0005523	molecular_function	tropomyosin binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005865	cellular_component	striated muscle thin filament
L	0005884	cellular_component	actin filament
L	0010628	biological_process	positive regulation of gene expression
L	0016787	molecular_function	hydrolase activity
L	0019904	molecular_function	protein domain specific binding
L	0030027	cellular_component	lamellipodium
L	0030041	biological_process	actin filament polymerization
L	0030175	cellular_component	filopodium
L	0030240	biological_process	skeletal muscle thin filament assembly
L	0031013	molecular_function	troponin I binding
L	0031432	molecular_function	titin binding
L	0031941	cellular_component	filamentous actin
L	0032036	molecular_function	myosin heavy chain binding
L	0032432	cellular_component	actin filament bundle
L	0042802	molecular_function	identical protein binding
L	0044297	cellular_component	cell body
L	0048306	molecular_function	calcium-dependent protein binding
L	0048741	biological_process	skeletal muscle fiber development
L	0051017	biological_process	actin filament bundle assembly
L	0090131	biological_process	mesenchyme migration
L	0098723	cellular_component	skeletal muscle myofibril
L	0140660	molecular_function	cytoskeletal motor activator activity

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
H	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITKqEYDE

Chain	Residue	Details
H	TRP356-GLU364

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
H	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	100
Details	Region: {"description":"Interaction with alpha-actinin","evidences":[{"source":"PubMed","id":"8449927","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P68134","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-malonyllysine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"1150665","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16905096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"213279","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2395459","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"499690","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ATN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NWK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68133","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"ADP-ribosylarginine; by SpvB","evidences":[{"source":"PubMed","id":"16905096","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---