9KBO

Crystal structure of human Shiftless (SFL) containing phosphorylation sites Ser249, Thr250, Thr253 and Ser256

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000932	cellular_component	P-body
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006449	biological_process	regulation of translational termination
A	0034340	biological_process	response to type I interferon
A	0034341	biological_process	response to type II interferon
A	0034342	biological_process	response to type III interferon
A	0035456	biological_process	response to interferon-beta
A	0043022	molecular_function	ribosome binding
A	0045071	biological_process	negative regulation of viral genome replication
A	0045087	biological_process	innate immune response
A	0051607	biological_process	defense response to virus
A	0075523	biological_process	viral translational frameshifting
A	1990825	molecular_function	sequence-specific mRNA binding
A	2001125	biological_process	negative regulation of translational frameshifting
B	0000932	cellular_component	P-body
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006449	biological_process	regulation of translational termination
B	0034340	biological_process	response to type I interferon
B	0034341	biological_process	response to type II interferon
B	0034342	biological_process	response to type III interferon
B	0035456	biological_process	response to interferon-beta
B	0043022	molecular_function	ribosome binding
B	0045071	biological_process	negative regulation of viral genome replication
B	0045087	biological_process	innate immune response
B	0051607	biological_process	defense response to virus
B	0075523	biological_process	viral translational frameshifting
B	1990825	molecular_function	sequence-specific mRNA binding
B	2001125	biological_process	negative regulation of translational frameshifting
C	0000932	cellular_component	P-body
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006449	biological_process	regulation of translational termination
C	0034340	biological_process	response to type I interferon
C	0034341	biological_process	response to type II interferon
C	0034342	biological_process	response to type III interferon
C	0035456	biological_process	response to interferon-beta
C	0043022	molecular_function	ribosome binding
C	0045071	biological_process	negative regulation of viral genome replication
C	0045087	biological_process	innate immune response
C	0051607	biological_process	defense response to virus
C	0075523	biological_process	viral translational frameshifting
C	1990825	molecular_function	sequence-specific mRNA binding
C	2001125	biological_process	negative regulation of translational frameshifting
D	0000932	cellular_component	P-body
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006449	biological_process	regulation of translational termination
D	0034340	biological_process	response to type I interferon
D	0034341	biological_process	response to type II interferon
D	0034342	biological_process	response to type III interferon
D	0035456	biological_process	response to interferon-beta
D	0043022	molecular_function	ribosome binding
D	0045071	biological_process	negative regulation of viral genome replication
D	0045087	biological_process	innate immune response
D	0051607	biological_process	defense response to virus
D	0075523	biological_process	viral translational frameshifting
D	1990825	molecular_function	sequence-specific mRNA binding
D	2001125	biological_process	negative regulation of translational frameshifting

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	144
Details	Region: {"description":"Interaction with PABPC1","evidences":[{"source":"PubMed","id":"26735137","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	64
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"26735137","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---