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9K7Q

Parkinson disease protein 7 (DJ-1) and Alpha-synuclein (Alpha-syn) complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000785cellular_componentchromatin
A0001046molecular_functioncore promoter sequence-specific DNA binding
A0002866biological_processpositive regulation of acute inflammatory response to antigenic stimulus
A0003690molecular_functiondouble-stranded DNA binding
A0003697molecular_functionsingle-stranded DNA binding
A0003713molecular_functiontranscription coactivator activity
A0003723molecular_functionRNA binding
A0003729molecular_functionmRNA binding
A0005102molecular_functionsignaling receptor binding
A0005507molecular_functioncopper ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005758cellular_componentmitochondrial intermembrane space
A0005759cellular_componentmitochondrial matrix
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005912cellular_componentadherens junction
A0006281biological_processDNA repair
A0006508biological_processproteolysis
A0006914biological_processautophagy
A0006954biological_processinflammatory response
A0006974biological_processDNA damage response
A0006979biological_processresponse to oxidative stress
A0007005biological_processmitochondrion organization
A0007265biological_processRas protein signal transduction
A0007338biological_processsingle fertilization
A0008021cellular_componentsynaptic vesicle
A0008047molecular_functionenzyme activator activity
A0008233molecular_functionpeptidase activity
A0009438biological_processmethylglyoxal metabolic process
A0010273biological_processdetoxification of copper ion
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0016532molecular_functionsuperoxide dismutase copper chaperone activity
A0016605cellular_componentPML body
A0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
A0016787molecular_functionhydrolase activity
A0019249biological_processlactate biosynthetic process
A0019430biological_processremoval of superoxide radicals
A0019826molecular_functionoxygen sensor activity
A0019899molecular_functionenzyme binding
A0019900molecular_functionkinase binding
A0019955molecular_functioncytokine binding
A0030073biological_processinsulin secretion
A0030091biological_processprotein repair
A0030414molecular_functionpeptidase inhibitor activity
A0030424cellular_componentaxon
A0030521biological_processandrogen receptor signaling pathway
A0030546molecular_functionsignaling receptor activator activity
A0031334biological_processpositive regulation of protein-containing complex assembly
A0031397biological_processnegative regulation of protein ubiquitination
A0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032679biological_processregulation of TRAIL production
A0032757biological_processpositive regulation of interleukin-8 production
A0033234biological_processnegative regulation of protein sumoylation
A0034599biological_processcellular response to oxidative stress
A0036470molecular_functiontyrosine 3-monooxygenase activator activity
A0036471biological_processcellular response to glyoxal
A0036478molecular_functionL-dopa decarboxylase activator activity
A0036524molecular_functionprotein deglycase activity
A0042177biological_processnegative regulation of protein catabolic process
A0042593biological_processglucose homeostasis
A0042743biological_processhydrogen peroxide metabolic process
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043005cellular_componentneuron projection
A0043523biological_processregulation of neuron apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0044297cellular_componentcell body
A0044388molecular_functionsmall protein activating enzyme binding
A0044390molecular_functionubiquitin-like protein conjugating enzyme binding
A0045121cellular_componentmembrane raft
A0045296molecular_functioncadherin binding
A0045340molecular_functionmercury ion binding
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046295biological_processglycolate biosynthetic process
A0046826biological_processnegative regulation of protein export from nucleus
A0048471cellular_componentperinuclear region of cytoplasm
A0050681molecular_functionnuclear androgen receptor binding
A0050727biological_processregulation of inflammatory response
A0050787biological_processdetoxification of mercury ion
A0050821biological_processprotein stabilization
A0051881biological_processregulation of mitochondrial membrane potential
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051920molecular_functionperoxiredoxin activity
A0055105molecular_functionubiquitin-protein transferase inhibitor activity
A0060765biological_processregulation of androgen receptor signaling pathway
A0061691biological_processdetoxification of hydrogen peroxide
A0061727biological_processmethylglyoxal catabolic process to lactate
A0070062cellular_componentextracellular exosome
A0070301biological_processcellular response to hydrogen peroxide
A0070994biological_processdetection of oxidative stress
A0097110molecular_functionscaffold protein binding
A0106044biological_processguanine deglycation
A0106045biological_processguanine deglycation, methylglyoxal removal
A0106046biological_processguanine deglycation, glyoxal removal
A0110095biological_processcellular detoxification of aldehyde
A0140041biological_processcellular detoxification of methylglyoxal
A0140297molecular_functionDNA-binding transcription factor binding
A1900182biological_processpositive regulation of protein localization to nucleus
A1900242biological_processregulation of synaptic vesicle endocytosis
A1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
A1902903biological_processregulation of supramolecular fiber organization
A1902958biological_processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
A1903073biological_processnegative regulation of death-inducing signaling complex assembly
A1903094biological_processnegative regulation of protein K48-linked deubiquitination
A1903122biological_processnegative regulation of TRAIL-activated apoptotic signaling pathway
A1903135molecular_functioncupric ion binding
A1903136molecular_functioncuprous ion binding
A1903181biological_processpositive regulation of dopamine biosynthetic process
A1903189biological_processglyoxal metabolic process
A1903190biological_processglyoxal catabolic process
A1903197biological_processpositive regulation of L-dopa biosynthetic process
A1903376biological_processregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
A1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
A1903384biological_processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
A1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
A1903599biological_processpositive regulation of autophagy of mitochondrion
A1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
A1905259biological_processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
A1990381molecular_functionubiquitin-specific protease binding
A1990422molecular_functionglyoxalase (glycolic acid-forming) activity
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
D0000785cellular_componentchromatin
D0001046molecular_functioncore promoter sequence-specific DNA binding
D0002866biological_processpositive regulation of acute inflammatory response to antigenic stimulus
D0003690molecular_functiondouble-stranded DNA binding
D0003697molecular_functionsingle-stranded DNA binding
D0003713molecular_functiontranscription coactivator activity
D0003723molecular_functionRNA binding
D0003729molecular_functionmRNA binding
D0005102molecular_functionsignaling receptor binding
D0005507molecular_functioncopper ion binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005758cellular_componentmitochondrial intermembrane space
D0005759cellular_componentmitochondrial matrix
D0005783cellular_componentendoplasmic reticulum
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005912cellular_componentadherens junction
D0006281biological_processDNA repair
D0006508biological_processproteolysis
D0006914biological_processautophagy
D0006954biological_processinflammatory response
D0006974biological_processDNA damage response
D0006979biological_processresponse to oxidative stress
D0007005biological_processmitochondrion organization
D0007265biological_processRas protein signal transduction
D0007338biological_processsingle fertilization
D0008021cellular_componentsynaptic vesicle
D0008047molecular_functionenzyme activator activity
D0008233molecular_functionpeptidase activity
D0009438biological_processmethylglyoxal metabolic process
D0010273biological_processdetoxification of copper ion
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0016532molecular_functionsuperoxide dismutase copper chaperone activity
D0016605cellular_componentPML body
D0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
D0016787molecular_functionhydrolase activity
D0019249biological_processlactate biosynthetic process
D0019430biological_processremoval of superoxide radicals
D0019826molecular_functionoxygen sensor activity
D0019899molecular_functionenzyme binding
D0019900molecular_functionkinase binding
D0019955molecular_functioncytokine binding
D0030073biological_processinsulin secretion
D0030091biological_processprotein repair
D0030414molecular_functionpeptidase inhibitor activity
D0030424cellular_componentaxon
D0030521biological_processandrogen receptor signaling pathway
D0030546molecular_functionsignaling receptor activator activity
D0031334biological_processpositive regulation of protein-containing complex assembly
D0031397biological_processnegative regulation of protein ubiquitination
D0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
D0032679biological_processregulation of TRAIL production
D0032757biological_processpositive regulation of interleukin-8 production
D0033234biological_processnegative regulation of protein sumoylation
D0034599biological_processcellular response to oxidative stress
D0036470molecular_functiontyrosine 3-monooxygenase activator activity
D0036471biological_processcellular response to glyoxal
D0036478molecular_functionL-dopa decarboxylase activator activity
D0036524molecular_functionprotein deglycase activity
D0042177biological_processnegative regulation of protein catabolic process
D0042593biological_processglucose homeostasis
D0042743biological_processhydrogen peroxide metabolic process
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043005cellular_componentneuron projection
D0043523biological_processregulation of neuron apoptotic process
D0043524biological_processnegative regulation of neuron apoptotic process
D0044297cellular_componentcell body
D0044388molecular_functionsmall protein activating enzyme binding
D0044390molecular_functionubiquitin-like protein conjugating enzyme binding
D0045121cellular_componentmembrane raft
D0045296molecular_functioncadherin binding
D0045340molecular_functionmercury ion binding
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046295biological_processglycolate biosynthetic process
D0046826biological_processnegative regulation of protein export from nucleus
D0048471cellular_componentperinuclear region of cytoplasm
D0050681molecular_functionnuclear androgen receptor binding
D0050727biological_processregulation of inflammatory response
D0050787biological_processdetoxification of mercury ion
D0050821biological_processprotein stabilization
D0051881biological_processregulation of mitochondrial membrane potential
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0051920molecular_functionperoxiredoxin activity
D0055105molecular_functionubiquitin-protein transferase inhibitor activity
D0060765biological_processregulation of androgen receptor signaling pathway
D0061691biological_processdetoxification of hydrogen peroxide
D0061727biological_processmethylglyoxal catabolic process to lactate
D0070062cellular_componentextracellular exosome
D0070301biological_processcellular response to hydrogen peroxide
D0070994biological_processdetection of oxidative stress
D0097110molecular_functionscaffold protein binding
D0106044biological_processguanine deglycation
D0106045biological_processguanine deglycation, methylglyoxal removal
D0106046biological_processguanine deglycation, glyoxal removal
D0110095biological_processcellular detoxification of aldehyde
D0140041biological_processcellular detoxification of methylglyoxal
D0140297molecular_functionDNA-binding transcription factor binding
D1900182biological_processpositive regulation of protein localization to nucleus
D1900242biological_processregulation of synaptic vesicle endocytosis
D1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
D1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
D1902903biological_processregulation of supramolecular fiber organization
D1902958biological_processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
D1903073biological_processnegative regulation of death-inducing signaling complex assembly
D1903094biological_processnegative regulation of protein K48-linked deubiquitination
D1903122biological_processnegative regulation of TRAIL-activated apoptotic signaling pathway
D1903135molecular_functioncupric ion binding
D1903136molecular_functioncuprous ion binding
D1903181biological_processpositive regulation of dopamine biosynthetic process
D1903189biological_processglyoxal metabolic process
D1903190biological_processglyoxal catabolic process
D1903197biological_processpositive regulation of L-dopa biosynthetic process
D1903376biological_processregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
D1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
D1903384biological_processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
D1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
D1903599biological_processpositive regulation of autophagy of mitochondrion
D1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
D1905259biological_processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
D1990381molecular_functionubiquitin-specific protease binding
D1990422molecular_functionglyoxalase (glycolic acid-forming) activity
D2000379biological_processpositive regulation of reactive oxygen species metabolic process
D2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
E0000785cellular_componentchromatin
E0001046molecular_functioncore promoter sequence-specific DNA binding
E0002866biological_processpositive regulation of acute inflammatory response to antigenic stimulus
E0003690molecular_functiondouble-stranded DNA binding
E0003697molecular_functionsingle-stranded DNA binding
E0003713molecular_functiontranscription coactivator activity
E0003723molecular_functionRNA binding
E0003729molecular_functionmRNA binding
E0005102molecular_functionsignaling receptor binding
E0005507molecular_functioncopper ion binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005758cellular_componentmitochondrial intermembrane space
E0005759cellular_componentmitochondrial matrix
E0005783cellular_componentendoplasmic reticulum
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0005912cellular_componentadherens junction
E0006281biological_processDNA repair
E0006508biological_processproteolysis
E0006914biological_processautophagy
E0006954biological_processinflammatory response
E0006974biological_processDNA damage response
E0006979biological_processresponse to oxidative stress
E0007005biological_processmitochondrion organization
E0007265biological_processRas protein signal transduction
E0007338biological_processsingle fertilization
E0008021cellular_componentsynaptic vesicle
E0008047molecular_functionenzyme activator activity
E0008233molecular_functionpeptidase activity
E0009438biological_processmethylglyoxal metabolic process
E0010273biological_processdetoxification of copper ion
E0010628biological_processpositive regulation of gene expression
E0010629biological_processnegative regulation of gene expression
E0016532molecular_functionsuperoxide dismutase copper chaperone activity
E0016605cellular_componentPML body
E0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
E0016787molecular_functionhydrolase activity
E0019249biological_processlactate biosynthetic process
E0019430biological_processremoval of superoxide radicals
E0019826molecular_functionoxygen sensor activity
E0019899molecular_functionenzyme binding
E0019900molecular_functionkinase binding
E0019955molecular_functioncytokine binding
E0030073biological_processinsulin secretion
E0030091biological_processprotein repair
E0030414molecular_functionpeptidase inhibitor activity
E0030424cellular_componentaxon
E0030521biological_processandrogen receptor signaling pathway
E0030546molecular_functionsignaling receptor activator activity
E0031334biological_processpositive regulation of protein-containing complex assembly
E0031397biological_processnegative regulation of protein ubiquitination
E0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
E0032679biological_processregulation of TRAIL production
E0032757biological_processpositive regulation of interleukin-8 production
E0033234biological_processnegative regulation of protein sumoylation
E0034599biological_processcellular response to oxidative stress
E0036470molecular_functiontyrosine 3-monooxygenase activator activity
E0036471biological_processcellular response to glyoxal
E0036478molecular_functionL-dopa decarboxylase activator activity
E0036524molecular_functionprotein deglycase activity
E0042177biological_processnegative regulation of protein catabolic process
E0042593biological_processglucose homeostasis
E0042743biological_processhydrogen peroxide metabolic process
E0042802molecular_functionidentical protein binding
E0042803molecular_functionprotein homodimerization activity
E0043005cellular_componentneuron projection
E0043523biological_processregulation of neuron apoptotic process
E0043524biological_processnegative regulation of neuron apoptotic process
E0044297cellular_componentcell body
E0044388molecular_functionsmall protein activating enzyme binding
E0044390molecular_functionubiquitin-like protein conjugating enzyme binding
E0045121cellular_componentmembrane raft
E0045296molecular_functioncadherin binding
E0045340molecular_functionmercury ion binding
E0045944biological_processpositive regulation of transcription by RNA polymerase II
E0046295biological_processglycolate biosynthetic process
E0046826biological_processnegative regulation of protein export from nucleus
E0048471cellular_componentperinuclear region of cytoplasm
E0050681molecular_functionnuclear androgen receptor binding
E0050727biological_processregulation of inflammatory response
E0050787biological_processdetoxification of mercury ion
E0050821biological_processprotein stabilization
E0051881biological_processregulation of mitochondrial membrane potential
E0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
E0051920molecular_functionperoxiredoxin activity
E0055105molecular_functionubiquitin-protein transferase inhibitor activity
E0060765biological_processregulation of androgen receptor signaling pathway
E0061691biological_processdetoxification of hydrogen peroxide
E0061727biological_processmethylglyoxal catabolic process to lactate
E0070062cellular_componentextracellular exosome
E0070301biological_processcellular response to hydrogen peroxide
E0070994biological_processdetection of oxidative stress
E0097110molecular_functionscaffold protein binding
E0106044biological_processguanine deglycation
E0106045biological_processguanine deglycation, methylglyoxal removal
E0106046biological_processguanine deglycation, glyoxal removal
E0110095biological_processcellular detoxification of aldehyde
E0140041biological_processcellular detoxification of methylglyoxal
E0140297molecular_functionDNA-binding transcription factor binding
E1900182biological_processpositive regulation of protein localization to nucleus
E1900242biological_processregulation of synaptic vesicle endocytosis
E1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
E1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
E1902903biological_processregulation of supramolecular fiber organization
E1902958biological_processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
E1903073biological_processnegative regulation of death-inducing signaling complex assembly
E1903094biological_processnegative regulation of protein K48-linked deubiquitination
E1903122biological_processnegative regulation of TRAIL-activated apoptotic signaling pathway
E1903135molecular_functioncupric ion binding
E1903136molecular_functioncuprous ion binding
E1903181biological_processpositive regulation of dopamine biosynthetic process
E1903189biological_processglyoxal metabolic process
E1903190biological_processglyoxal catabolic process
E1903197biological_processpositive regulation of L-dopa biosynthetic process
E1903376biological_processregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
E1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
E1903384biological_processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
E1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
E1903599biological_processpositive regulation of autophagy of mitochondrion
E1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
E1905259biological_processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
E1990381molecular_functionubiquitin-specific protease binding
E1990422molecular_functionglyoxalase (glycolic acid-forming) activity
E2000379biological_processpositive regulation of reactive oxygen species metabolic process
E2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
F0000785cellular_componentchromatin
F0001046molecular_functioncore promoter sequence-specific DNA binding
F0002866biological_processpositive regulation of acute inflammatory response to antigenic stimulus
F0003690molecular_functiondouble-stranded DNA binding
F0003697molecular_functionsingle-stranded DNA binding
F0003713molecular_functiontranscription coactivator activity
F0003723molecular_functionRNA binding
F0003729molecular_functionmRNA binding
F0005102molecular_functionsignaling receptor binding
F0005507molecular_functioncopper ion binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005758cellular_componentmitochondrial intermembrane space
F0005759cellular_componentmitochondrial matrix
F0005783cellular_componentendoplasmic reticulum
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005912cellular_componentadherens junction
F0006281biological_processDNA repair
F0006508biological_processproteolysis
F0006914biological_processautophagy
F0006954biological_processinflammatory response
F0006974biological_processDNA damage response
F0006979biological_processresponse to oxidative stress
F0007005biological_processmitochondrion organization
F0007265biological_processRas protein signal transduction
F0007338biological_processsingle fertilization
F0008021cellular_componentsynaptic vesicle
F0008047molecular_functionenzyme activator activity
F0008233molecular_functionpeptidase activity
F0009438biological_processmethylglyoxal metabolic process
F0010273biological_processdetoxification of copper ion
F0010628biological_processpositive regulation of gene expression
F0010629biological_processnegative regulation of gene expression
F0016532molecular_functionsuperoxide dismutase copper chaperone activity
F0016605cellular_componentPML body
F0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
F0016787molecular_functionhydrolase activity
F0019249biological_processlactate biosynthetic process
F0019430biological_processremoval of superoxide radicals
F0019826molecular_functionoxygen sensor activity
F0019899molecular_functionenzyme binding
F0019900molecular_functionkinase binding
F0019955molecular_functioncytokine binding
F0030073biological_processinsulin secretion
F0030091biological_processprotein repair
F0030414molecular_functionpeptidase inhibitor activity
F0030424cellular_componentaxon
F0030521biological_processandrogen receptor signaling pathway
F0030546molecular_functionsignaling receptor activator activity
F0031334biological_processpositive regulation of protein-containing complex assembly
F0031397biological_processnegative regulation of protein ubiquitination
F0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
F0032679biological_processregulation of TRAIL production
F0032757biological_processpositive regulation of interleukin-8 production
F0033234biological_processnegative regulation of protein sumoylation
F0034599biological_processcellular response to oxidative stress
F0036470molecular_functiontyrosine 3-monooxygenase activator activity
F0036471biological_processcellular response to glyoxal
F0036478molecular_functionL-dopa decarboxylase activator activity
F0036524molecular_functionprotein deglycase activity
F0042177biological_processnegative regulation of protein catabolic process
F0042593biological_processglucose homeostasis
F0042743biological_processhydrogen peroxide metabolic process
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0043005cellular_componentneuron projection
F0043523biological_processregulation of neuron apoptotic process
F0043524biological_processnegative regulation of neuron apoptotic process
F0044297cellular_componentcell body
F0044388molecular_functionsmall protein activating enzyme binding
F0044390molecular_functionubiquitin-like protein conjugating enzyme binding
F0045121cellular_componentmembrane raft
F0045296molecular_functioncadherin binding
F0045340molecular_functionmercury ion binding
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0046295biological_processglycolate biosynthetic process
F0046826biological_processnegative regulation of protein export from nucleus
F0048471cellular_componentperinuclear region of cytoplasm
F0050681molecular_functionnuclear androgen receptor binding
F0050727biological_processregulation of inflammatory response
F0050787biological_processdetoxification of mercury ion
F0050821biological_processprotein stabilization
F0051881biological_processregulation of mitochondrial membrane potential
F0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F0051920molecular_functionperoxiredoxin activity
F0055105molecular_functionubiquitin-protein transferase inhibitor activity
F0060765biological_processregulation of androgen receptor signaling pathway
F0061691biological_processdetoxification of hydrogen peroxide
F0061727biological_processmethylglyoxal catabolic process to lactate
F0070062cellular_componentextracellular exosome
F0070301biological_processcellular response to hydrogen peroxide
F0070994biological_processdetection of oxidative stress
F0097110molecular_functionscaffold protein binding
F0106044biological_processguanine deglycation
F0106045biological_processguanine deglycation, methylglyoxal removal
F0106046biological_processguanine deglycation, glyoxal removal
F0110095biological_processcellular detoxification of aldehyde
F0140041biological_processcellular detoxification of methylglyoxal
F0140297molecular_functionDNA-binding transcription factor binding
F1900182biological_processpositive regulation of protein localization to nucleus
F1900242biological_processregulation of synaptic vesicle endocytosis
F1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
F1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
F1902903biological_processregulation of supramolecular fiber organization
F1902958biological_processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
F1903073biological_processnegative regulation of death-inducing signaling complex assembly
F1903094biological_processnegative regulation of protein K48-linked deubiquitination
F1903122biological_processnegative regulation of TRAIL-activated apoptotic signaling pathway
F1903135molecular_functioncupric ion binding
F1903136molecular_functioncuprous ion binding
F1903181biological_processpositive regulation of dopamine biosynthetic process
F1903189biological_processglyoxal metabolic process
F1903190biological_processglyoxal catabolic process
F1903197biological_processpositive regulation of L-dopa biosynthetic process
F1903376biological_processregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
F1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
F1903384biological_processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
F1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
F1903599biological_processpositive regulation of autophagy of mitochondrion
F1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
F1905259biological_processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
F1990381molecular_functionubiquitin-specific protease binding
F1990422molecular_functionglyoxalase (glycolic acid-forming) activity
F2000379biological_processpositive regulation of reactive oxygen species metabolic process
F2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
H0000785cellular_componentchromatin
H0001046molecular_functioncore promoter sequence-specific DNA binding
H0002866biological_processpositive regulation of acute inflammatory response to antigenic stimulus
H0003690molecular_functiondouble-stranded DNA binding
H0003697molecular_functionsingle-stranded DNA binding
H0003713molecular_functiontranscription coactivator activity
H0003723molecular_functionRNA binding
H0003729molecular_functionmRNA binding
H0005102molecular_functionsignaling receptor binding
H0005507molecular_functioncopper ion binding
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005758cellular_componentmitochondrial intermembrane space
H0005759cellular_componentmitochondrial matrix
H0005783cellular_componentendoplasmic reticulum
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0005912cellular_componentadherens junction
H0006281biological_processDNA repair
H0006508biological_processproteolysis
H0006914biological_processautophagy
H0006954biological_processinflammatory response
H0006974biological_processDNA damage response
H0006979biological_processresponse to oxidative stress
H0007005biological_processmitochondrion organization
H0007265biological_processRas protein signal transduction
H0007338biological_processsingle fertilization
H0008021cellular_componentsynaptic vesicle
H0008047molecular_functionenzyme activator activity
H0008233molecular_functionpeptidase activity
H0009438biological_processmethylglyoxal metabolic process
H0010273biological_processdetoxification of copper ion
H0010628biological_processpositive regulation of gene expression
H0010629biological_processnegative regulation of gene expression
H0016532molecular_functionsuperoxide dismutase copper chaperone activity
H0016605cellular_componentPML body
H0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
H0016787molecular_functionhydrolase activity
H0019249biological_processlactate biosynthetic process
H0019430biological_processremoval of superoxide radicals
H0019826molecular_functionoxygen sensor activity
H0019899molecular_functionenzyme binding
H0019900molecular_functionkinase binding
H0019955molecular_functioncytokine binding
H0030073biological_processinsulin secretion
H0030091biological_processprotein repair
H0030414molecular_functionpeptidase inhibitor activity
H0030424cellular_componentaxon
H0030521biological_processandrogen receptor signaling pathway
H0030546molecular_functionsignaling receptor activator activity
H0031334biological_processpositive regulation of protein-containing complex assembly
H0031397biological_processnegative regulation of protein ubiquitination
H0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
H0032679biological_processregulation of TRAIL production
H0032757biological_processpositive regulation of interleukin-8 production
H0033234biological_processnegative regulation of protein sumoylation
H0034599biological_processcellular response to oxidative stress
H0036470molecular_functiontyrosine 3-monooxygenase activator activity
H0036471biological_processcellular response to glyoxal
H0036478molecular_functionL-dopa decarboxylase activator activity
H0036524molecular_functionprotein deglycase activity
H0042177biological_processnegative regulation of protein catabolic process
H0042593biological_processglucose homeostasis
H0042743biological_processhydrogen peroxide metabolic process
H0042802molecular_functionidentical protein binding
H0042803molecular_functionprotein homodimerization activity
H0043005cellular_componentneuron projection
H0043523biological_processregulation of neuron apoptotic process
H0043524biological_processnegative regulation of neuron apoptotic process
H0044297cellular_componentcell body
H0044388molecular_functionsmall protein activating enzyme binding
H0044390molecular_functionubiquitin-like protein conjugating enzyme binding
H0045121cellular_componentmembrane raft
H0045296molecular_functioncadherin binding
H0045340molecular_functionmercury ion binding
H0045944biological_processpositive regulation of transcription by RNA polymerase II
H0046295biological_processglycolate biosynthetic process
H0046826biological_processnegative regulation of protein export from nucleus
H0048471cellular_componentperinuclear region of cytoplasm
H0050681molecular_functionnuclear androgen receptor binding
H0050727biological_processregulation of inflammatory response
H0050787biological_processdetoxification of mercury ion
H0050821biological_processprotein stabilization
H0051881biological_processregulation of mitochondrial membrane potential
H0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
H0051920molecular_functionperoxiredoxin activity
H0055105molecular_functionubiquitin-protein transferase inhibitor activity
H0060765biological_processregulation of androgen receptor signaling pathway
H0061691biological_processdetoxification of hydrogen peroxide
H0061727biological_processmethylglyoxal catabolic process to lactate
H0070062cellular_componentextracellular exosome
H0070301biological_processcellular response to hydrogen peroxide
H0070994biological_processdetection of oxidative stress
H0097110molecular_functionscaffold protein binding
H0106044biological_processguanine deglycation
H0106045biological_processguanine deglycation, methylglyoxal removal
H0106046biological_processguanine deglycation, glyoxal removal
H0110095biological_processcellular detoxification of aldehyde
H0140041biological_processcellular detoxification of methylglyoxal
H0140297molecular_functionDNA-binding transcription factor binding
H1900182biological_processpositive regulation of protein localization to nucleus
H1900242biological_processregulation of synaptic vesicle endocytosis
H1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
H1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
H1902903biological_processregulation of supramolecular fiber organization
H1902958biological_processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
H1903073biological_processnegative regulation of death-inducing signaling complex assembly
H1903094biological_processnegative regulation of protein K48-linked deubiquitination
H1903122biological_processnegative regulation of TRAIL-activated apoptotic signaling pathway
H1903135molecular_functioncupric ion binding
H1903136molecular_functioncuprous ion binding
H1903181biological_processpositive regulation of dopamine biosynthetic process
H1903189biological_processglyoxal metabolic process
H1903190biological_processglyoxal catabolic process
H1903197biological_processpositive regulation of L-dopa biosynthetic process
H1903376biological_processregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
H1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
H1903384biological_processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
H1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
H1903599biological_processpositive regulation of autophagy of mitochondrion
H1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
H1905259biological_processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
H1990381molecular_functionubiquitin-specific protease binding
H1990422molecular_functionglyoxalase (glycolic acid-forming) activity
H2000379biological_processpositive regulation of reactive oxygen species metabolic process
H2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
J0000785cellular_componentchromatin
J0001046molecular_functioncore promoter sequence-specific DNA binding
J0002866biological_processpositive regulation of acute inflammatory response to antigenic stimulus
J0003690molecular_functiondouble-stranded DNA binding
J0003697molecular_functionsingle-stranded DNA binding
J0003713molecular_functiontranscription coactivator activity
J0003723molecular_functionRNA binding
J0003729molecular_functionmRNA binding
J0005102molecular_functionsignaling receptor binding
J0005507molecular_functioncopper ion binding
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005758cellular_componentmitochondrial intermembrane space
J0005759cellular_componentmitochondrial matrix
J0005783cellular_componentendoplasmic reticulum
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0005912cellular_componentadherens junction
J0006281biological_processDNA repair
J0006508biological_processproteolysis
J0006914biological_processautophagy
J0006954biological_processinflammatory response
J0006974biological_processDNA damage response
J0006979biological_processresponse to oxidative stress
J0007005biological_processmitochondrion organization
J0007265biological_processRas protein signal transduction
J0007338biological_processsingle fertilization
J0008021cellular_componentsynaptic vesicle
J0008047molecular_functionenzyme activator activity
J0008233molecular_functionpeptidase activity
J0009438biological_processmethylglyoxal metabolic process
J0010273biological_processdetoxification of copper ion
J0010628biological_processpositive regulation of gene expression
J0010629biological_processnegative regulation of gene expression
J0016532molecular_functionsuperoxide dismutase copper chaperone activity
J0016605cellular_componentPML body
J0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
J0016787molecular_functionhydrolase activity
J0019249biological_processlactate biosynthetic process
J0019430biological_processremoval of superoxide radicals
J0019826molecular_functionoxygen sensor activity
J0019899molecular_functionenzyme binding
J0019900molecular_functionkinase binding
J0019955molecular_functioncytokine binding
J0030073biological_processinsulin secretion
J0030091biological_processprotein repair
J0030414molecular_functionpeptidase inhibitor activity
J0030424cellular_componentaxon
J0030521biological_processandrogen receptor signaling pathway
J0030546molecular_functionsignaling receptor activator activity
J0031334biological_processpositive regulation of protein-containing complex assembly
J0031397biological_processnegative regulation of protein ubiquitination
J0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
J0032679biological_processregulation of TRAIL production
J0032757biological_processpositive regulation of interleukin-8 production
J0033234biological_processnegative regulation of protein sumoylation
J0034599biological_processcellular response to oxidative stress
J0036470molecular_functiontyrosine 3-monooxygenase activator activity
J0036471biological_processcellular response to glyoxal
J0036478molecular_functionL-dopa decarboxylase activator activity
J0036524molecular_functionprotein deglycase activity
J0042177biological_processnegative regulation of protein catabolic process
J0042593biological_processglucose homeostasis
J0042743biological_processhydrogen peroxide metabolic process
J0042802molecular_functionidentical protein binding
J0042803molecular_functionprotein homodimerization activity
J0043005cellular_componentneuron projection
J0043523biological_processregulation of neuron apoptotic process
J0043524biological_processnegative regulation of neuron apoptotic process
J0044297cellular_componentcell body
J0044388molecular_functionsmall protein activating enzyme binding
J0044390molecular_functionubiquitin-like protein conjugating enzyme binding
J0045121cellular_componentmembrane raft
J0045296molecular_functioncadherin binding
J0045340molecular_functionmercury ion binding
J0045944biological_processpositive regulation of transcription by RNA polymerase II
J0046295biological_processglycolate biosynthetic process
J0046826biological_processnegative regulation of protein export from nucleus
J0048471cellular_componentperinuclear region of cytoplasm
J0050681molecular_functionnuclear androgen receptor binding
J0050727biological_processregulation of inflammatory response
J0050787biological_processdetoxification of mercury ion
J0050821biological_processprotein stabilization
J0051881biological_processregulation of mitochondrial membrane potential
J0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
J0051920molecular_functionperoxiredoxin activity
J0055105molecular_functionubiquitin-protein transferase inhibitor activity
J0060765biological_processregulation of androgen receptor signaling pathway
J0061691biological_processdetoxification of hydrogen peroxide
J0061727biological_processmethylglyoxal catabolic process to lactate
J0070062cellular_componentextracellular exosome
J0070301biological_processcellular response to hydrogen peroxide
J0070994biological_processdetection of oxidative stress
J0097110molecular_functionscaffold protein binding
J0106044biological_processguanine deglycation
J0106045biological_processguanine deglycation, methylglyoxal removal
J0106046biological_processguanine deglycation, glyoxal removal
J0110095biological_processcellular detoxification of aldehyde
J0140041biological_processcellular detoxification of methylglyoxal
J0140297molecular_functionDNA-binding transcription factor binding
J1900182biological_processpositive regulation of protein localization to nucleus
J1900242biological_processregulation of synaptic vesicle endocytosis
J1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
J1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
J1902903biological_processregulation of supramolecular fiber organization
J1902958biological_processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
J1903073biological_processnegative regulation of death-inducing signaling complex assembly
J1903094biological_processnegative regulation of protein K48-linked deubiquitination
J1903122biological_processnegative regulation of TRAIL-activated apoptotic signaling pathway
J1903135molecular_functioncupric ion binding
J1903136molecular_functioncuprous ion binding
J1903181biological_processpositive regulation of dopamine biosynthetic process
J1903189biological_processglyoxal metabolic process
J1903190biological_processglyoxal catabolic process
J1903197biological_processpositive regulation of L-dopa biosynthetic process
J1903376biological_processregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
J1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
J1903384biological_processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
J1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
J1903599biological_processpositive regulation of autophagy of mitochondrion
J1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
J1905259biological_processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
J1990381molecular_functionubiquitin-specific protease binding
J1990422molecular_functionglyoxalase (glycolic acid-forming) activity
J2000379biological_processpositive regulation of reactive oxygen species metabolic process
J2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"20304780","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25416785","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues6
DetailsActive site: {"evidences":[{"source":"PubMed","id":"20304780","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues6
DetailsSite: {"description":"Cleavage; by CASP6","evidences":[{"source":"UniProtKB","id":"Q99LX0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues6
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues6
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues6
DetailsModified residue: {"description":"Cysteine sulfinic acid (-SO2H); alternate","evidences":[{"source":"PubMed","id":"12939276","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q99LX0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues6
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q99LX0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues12
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"23847046","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues6
DetailsLipidation: {"description":"S-palmitoyl cysteine; alternate","evidences":[{"source":"PubMed","id":"23847046","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues12
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"15976810","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues10
DetailsRepeat: {"description":"1"}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues10
DetailsRepeat: {"description":"2"}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues14
DetailsRepeat: {"description":"3; approximate"}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues10
DetailsRepeat: {"description":"4"}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues47
DetailsRegion: {"description":"4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)"}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues2
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues1
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22407793","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI19
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"10617630","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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