Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9K3V

Human RNA Polymerase III de novo transcribing complex 4 (TC4)

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000995	molecular_function	RNA polymerase III general transcription initiation factor activity
1	0003677	molecular_function	DNA binding
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005730	cellular_component	nucleolus
1	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
1	0019185	cellular_component	snRNA-activating protein complex
1	0042795	biological_process	snRNA transcription by RNA polymerase II
1	0042796	biological_process	snRNA transcription by RNA polymerase III
1	0043565	molecular_function	sequence-specific DNA binding
3	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
3	0000995	molecular_function	RNA polymerase III general transcription initiation factor activity
3	0001006	molecular_function	RNA polymerase III type 3 promoter sequence-specific DNA binding
3	0001046	molecular_function	core promoter sequence-specific DNA binding
3	0003677	molecular_function	DNA binding
3	0003681	molecular_function	bent DNA binding
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005730	cellular_component	nucleolus
3	0006366	biological_process	transcription by RNA polymerase II
3	0006383	biological_process	transcription by RNA polymerase III
3	0009301	biological_process	snRNA transcription
3	0016604	cellular_component	nuclear body
3	0019185	cellular_component	snRNA-activating protein complex
3	0042795	biological_process	snRNA transcription by RNA polymerase II
3	0042796	biological_process	snRNA transcription by RNA polymerase III
4	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
4	0000995	molecular_function	RNA polymerase III general transcription initiation factor activity
4	0001006	molecular_function	RNA polymerase III type 3 promoter sequence-specific DNA binding
4	0003677	molecular_function	DNA binding
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
4	0019185	cellular_component	snRNA-activating protein complex
4	0042795	biological_process	snRNA transcription by RNA polymerase II
4	0042796	biological_process	snRNA transcription by RNA polymerase III
A	0000287	molecular_function	magnesium ion binding
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0002376	biological_process	immune system process
A	0003682	molecular_function	chromatin binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005666	cellular_component	RNA polymerase III complex
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006351	biological_process	DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0010628	biological_process	positive regulation of gene expression
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0032728	biological_process	positive regulation of interferon-beta production
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0042797	biological_process	tRNA transcription by RNA polymerase III
A	0045087	biological_process	innate immune response
A	0046872	molecular_function	metal ion binding
A	0051607	biological_process	defense response to virus
A	0071667	molecular_function	DNA/RNA hybrid binding
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0002376	biological_process	immune system process
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005666	cellular_component	RNA polymerase III complex
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006383	biological_process	transcription by RNA polymerase III
B	0008270	molecular_function	zinc ion binding
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0032728	biological_process	positive regulation of interferon-beta production
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0042796	biological_process	snRNA transcription by RNA polymerase III
B	0045087	biological_process	innate immune response
B	0045089	biological_process	positive regulation of innate immune response
B	0046872	molecular_function	metal ion binding
B	0051607	biological_process	defense response to virus
B	0055029	cellular_component	nuclear DNA-directed RNA polymerase complex
B	0071667	molecular_function	DNA/RNA hybrid binding
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0001650	cellular_component	fibrillar center
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005666	cellular_component	RNA polymerase III complex
C	0005730	cellular_component	nucleolus
C	0005736	cellular_component	RNA polymerase I complex
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006360	biological_process	transcription by RNA polymerase I
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0001635	molecular_function	calcitonin gene-related peptide receptor activity
D	0001669	cellular_component	acrosomal vesicle
D	0002376	biological_process	immune system process
D	0003899	molecular_function	DNA-directed RNA polymerase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005666	cellular_component	RNA polymerase III complex
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006383	biological_process	transcription by RNA polymerase III
D	0006384	biological_process	transcription initiation at RNA polymerase III promoter
D	0007218	biological_process	neuropeptide signaling pathway
D	0009360	cellular_component	DNA polymerase III complex
D	0045087	biological_process	innate immune response
D	0051607	biological_process	defense response to virus
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005730	cellular_component	nucleolus
E	0005736	cellular_component	RNA polymerase I complex
E	0005829	cellular_component	cytosol
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006366	biological_process	transcription by RNA polymerase II
E	0042797	biological_process	tRNA transcription by RNA polymerase III
E	0050821	biological_process	protein stabilization
E	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001650	cellular_component	fibrillar center
F	0003899	molecular_function	DNA-directed RNA polymerase activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005730	cellular_component	nucleolus
F	0005736	cellular_component	RNA polymerase I complex
F	0005829	cellular_component	cytosol
F	0006360	biological_process	transcription by RNA polymerase I
F	0006366	biological_process	transcription by RNA polymerase II
F	0042797	biological_process	tRNA transcription by RNA polymerase III
G	0000428	cellular_component	DNA-directed RNA polymerase complex
G	0002376	biological_process	immune system process
G	0003899	molecular_function	DNA-directed RNA polymerase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005666	cellular_component	RNA polymerase III complex
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0006139	biological_process	nucleobase-containing compound metabolic process
G	0006383	biological_process	transcription by RNA polymerase III
G	0006384	biological_process	transcription initiation at RNA polymerase III promoter
G	0045087	biological_process	innate immune response
G	0051607	biological_process	defense response to virus
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0003677	molecular_function	DNA binding
H	0003697	molecular_function	single-stranded DNA binding
H	0003899	molecular_function	DNA-directed RNA polymerase activity
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005665	cellular_component	RNA polymerase II, core complex
H	0005666	cellular_component	RNA polymerase III complex
H	0005730	cellular_component	nucleolus
H	0005736	cellular_component	RNA polymerase I complex
H	0005829	cellular_component	cytosol
H	0006366	biological_process	transcription by RNA polymerase II
H	0032993	cellular_component	protein-DNA complex
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0002376	biological_process	immune system process
I	0003899	molecular_function	DNA-directed RNA polymerase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005666	cellular_component	RNA polymerase III complex
I	0005829	cellular_component	cytosol
I	0006383	biological_process	transcription by RNA polymerase III
I	0008270	molecular_function	zinc ion binding
I	0045087	biological_process	innate immune response
I	0046872	molecular_function	metal ion binding
I	0051607	biological_process	defense response to virus
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0003899	molecular_function	DNA-directed RNA polymerase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005665	cellular_component	RNA polymerase II, core complex
J	0005666	cellular_component	RNA polymerase III complex
J	0005730	cellular_component	nucleolus
J	0005736	cellular_component	RNA polymerase I complex
J	0005829	cellular_component	cytosol
J	0006356	biological_process	regulation of transcription by RNA polymerase I
J	0006360	biological_process	transcription by RNA polymerase I
J	0006366	biological_process	transcription by RNA polymerase II
J	0008270	molecular_function	zinc ion binding
J	0042797	biological_process	tRNA transcription by RNA polymerase III
J	0046872	molecular_function	metal ion binding
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0003899	molecular_function	DNA-directed RNA polymerase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005666	cellular_component	RNA polymerase III complex
K	0005730	cellular_component	nucleolus
K	0005736	cellular_component	RNA polymerase I complex
K	0006362	biological_process	transcription elongation by RNA polymerase I
K	0006383	biological_process	transcription by RNA polymerase III
K	0055029	cellular_component	nuclear DNA-directed RNA polymerase complex
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005730	cellular_component	nucleolus
L	0005736	cellular_component	RNA polymerase I complex
L	0005829	cellular_component	cytosol
L	0006356	biological_process	regulation of transcription by RNA polymerase I
L	0006366	biological_process	transcription by RNA polymerase II
L	0006383	biological_process	transcription by RNA polymerase III
L	0008270	molecular_function	zinc ion binding
L	0046872	molecular_function	metal ion binding
M	0000428	cellular_component	DNA-directed RNA polymerase complex
M	0002376	biological_process	immune system process
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005666	cellular_component	RNA polymerase III complex
M	0005829	cellular_component	cytosol
M	0045087	biological_process	innate immune response
M	0051607	biological_process	defense response to virus
N	0000428	cellular_component	DNA-directed RNA polymerase complex
N	0002376	biological_process	immune system process
N	0003682	molecular_function	chromatin binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005666	cellular_component	RNA polymerase III complex
N	0005829	cellular_component	cytosol
N	0032728	biological_process	positive regulation of interferon-beta production
N	0042797	biological_process	tRNA transcription by RNA polymerase III
N	0045087	biological_process	innate immune response
N	0045089	biological_process	positive regulation of innate immune response
N	0051607	biological_process	defense response to virus
O	0000428	cellular_component	DNA-directed RNA polymerase complex
O	0002376	biological_process	immune system process
O	0003677	molecular_function	DNA binding
O	0003697	molecular_function	single-stranded DNA binding
O	0003899	molecular_function	DNA-directed RNA polymerase activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005666	cellular_component	RNA polymerase III complex
O	0005829	cellular_component	cytosol
O	0006359	biological_process	regulation of transcription by RNA polymerase III
O	0032728	biological_process	positive regulation of interferon-beta production
O	0045087	biological_process	innate immune response
O	0045089	biological_process	positive regulation of innate immune response
O	0051607	biological_process	defense response to virus
P	0000428	cellular_component	DNA-directed RNA polymerase complex
P	0002376	biological_process	immune system process
P	0003677	molecular_function	DNA binding
P	0003690	molecular_function	double-stranded DNA binding
P	0003899	molecular_function	DNA-directed RNA polymerase activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005666	cellular_component	RNA polymerase III complex
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006359	biological_process	regulation of transcription by RNA polymerase III
P	0032728	biological_process	positive regulation of interferon-beta production
P	0045087	biological_process	innate immune response
P	0045089	biological_process	positive regulation of innate immune response
P	0051539	molecular_function	4 iron, 4 sulfur cluster binding
P	0051607	biological_process	defense response to virus
Q	0000428	cellular_component	DNA-directed RNA polymerase complex
Q	0002376	biological_process	immune system process
Q	0003682	molecular_function	chromatin binding
Q	0003899	molecular_function	DNA-directed RNA polymerase activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005666	cellular_component	RNA polymerase III complex
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006359	biological_process	regulation of transcription by RNA polymerase III
Q	0006383	biological_process	transcription by RNA polymerase III
Q	0008283	biological_process	cell population proliferation
Q	0016604	cellular_component	nuclear body
Q	0032728	biological_process	positive regulation of interferon-beta production
Q	0045087	biological_process	innate immune response
Q	0045089	biological_process	positive regulation of innate immune response
Q	0051607	biological_process	defense response to virus
U	0000785	cellular_component	chromatin
U	0000791	cellular_component	euchromatin
U	0000976	molecular_function	transcription cis-regulatory region binding
U	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
U	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
U	0000995	molecular_function	RNA polymerase III general transcription initiation factor activity
U	0001046	molecular_function	core promoter sequence-specific DNA binding
U	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
U	0001093	molecular_function	TFIIB-class transcription factor binding
U	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
U	0001188	biological_process	RNA polymerase I preinitiation complex assembly
U	0001673	cellular_component	male germ cell nucleus
U	0001674	cellular_component	female germ cell nucleus
U	0001939	cellular_component	female pronucleus
U	0001940	cellular_component	male pronucleus
U	0003677	molecular_function	DNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005668	cellular_component	RNA polymerase transcription factor SL1 complex
U	0005669	cellular_component	transcription factor TFIID complex
U	0005672	cellular_component	transcription factor TFIIA complex
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0006352	biological_process	DNA-templated transcription initiation
U	0006366	biological_process	transcription by RNA polymerase II
U	0006367	biological_process	transcription initiation at RNA polymerase II promoter
U	0006383	biological_process	transcription by RNA polymerase III
U	0007283	biological_process	spermatogenesis
U	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
U	0017162	molecular_function	aryl hydrocarbon receptor binding
U	0019899	molecular_function	enzyme binding
U	0032991	cellular_component	protein-containing complex
U	0042789	biological_process	mRNA transcription by RNA polymerase II
U	0045120	cellular_component	pronucleus
U	0045893	biological_process	positive regulation of DNA-templated transcription
U	0051123	biological_process	RNA polymerase II preinitiation complex assembly
U	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
U	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
U	0140297	molecular_function	DNA-binding transcription factor binding
V	0000126	cellular_component	transcription factor TFIIIB complex
V	0001006	molecular_function	RNA polymerase III type 3 promoter sequence-specific DNA binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0006359	biological_process	regulation of transcription by RNA polymerase III
V	0006366	biological_process	transcription by RNA polymerase II
V	0008270	molecular_function	zinc ion binding
V	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
V	0017025	molecular_function	TBP-class protein binding
V	0034599	biological_process	cellular response to oxidative stress
V	0046872	molecular_function	metal ion binding
V	0097550	cellular_component	transcription preinitiation complex
W	0000126	cellular_component	transcription factor TFIIIB complex
W	0001156	molecular_function	TFIIIC-class transcription factor complex binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0070898	biological_process	RNA polymerase III preinitiation complex assembly

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FRCVVFH

Chain	Residue	Details
G	PHE72-HIS78

site_id	PS00351
Number of Residues	50
Details	TFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePRttaLIFsSGKMvctGAKseeqsrlAarkyarvV

Chain	Residue	Details
U	TYR192-VAL241
U	TYR283-LEU332

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NAFRRillaevptmAvekVlvynNtSivqDEiLAhRLGLIP

Chain	Residue	Details
C	ASN74-PRO114

site_id	PS00466
Number of Residues	38
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CpkCehprayfmqLQTRSaDEPmttfykCcnaq.CghrW

Chain	Residue	Details
I	CYS69-TRP106

site_id	PS00697
Number of Residues	9
Details	DNA_LIGASE_A1 ATP-dependent DNA ligase AMP-binding site. EEKTNGWRI

Chain	Residue	Details
W	GLU344-ILE352

site_id	PS01030
Number of Residues	25
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCPGCGNGLiveegqrchrfa..CntC

Chain	Residue	Details
I	PHE4-CYS28

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
E	HIS142-GLU155

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
F	THR58-GLN72

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
J	ILE2-GLY11

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. LheEdHTLgNsLrymImknpeVefcgYtttHP

Chain	Residue	Details
K	LEU44-PRO75

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFSSrHGQKGV

Chain	Residue	Details
B	GLY894-VAL906

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	Domain: {"description":"Myb-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	54
Details	Domain: {"description":"HTH myb-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00625","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	24
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00625","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	41
Details	Region: {"description":"Bridging helix","evidences":[{"source":"UniProtKB","id":"G3MZY8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	41
Details	Region: {"description":"Trigger loop","evidences":[{"source":"UniProtKB","id":"G3MZY8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34675218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7FJJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34675218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7FJJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34675218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7FJJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7A6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P24928","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P04050","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34675218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7FJJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	15
Details	Zinc finger: {"description":"C4-type","evidences":[{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34675218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7FJJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34675218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7FJJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P08518","evidenceCode":"ECO:0000250"},{"source":"UniProtKB","id":"P30876","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34675218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7FJJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	1
Details	Site: {"description":"Critical in trapping poly(dT) in Pol III-mediated transcription termination","evidences":[{"source":"PubMed","id":"34675218","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	24
Details	Region: {"description":"Non-specific ssDNA binding"}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"AUG-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	23
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10145","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34675218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7FJI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	20
Details	Zinc finger: {"description":"C4-type","evidences":[{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5IY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5IY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	44
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	9
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI45
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI46
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI47
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI48
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI49
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI50
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI51
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI52
Number of Residues	161
Details	Repeat: {"description":"1"}

Chain

Residue

Details

site_id	SWS_FT_FI53
Number of Residues	153
Details	Repeat: {"description":"2"}

Chain

Residue

Details

site_id	SWS_FT_FI54
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IYD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI55
Number of Residues	6
Details	Region: {"description":"Interaction with target DNA","evidences":[{"source":"PubMed","id":"26638071","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ROC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ROD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ROE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI56
Number of Residues	6
Details	Region: {"description":"Required for the formation of a ternary complex with DNA and TBP; not required for interaction with TBP in the absence of DNA","evidences":[{"source":"PubMed","id":"26638071","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI57
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00469","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI58
Number of Residues	1
Details	Modified residue: {"description":"Cysteine sulfenic acid (-SOH)","evidences":[{"source":"PubMed","id":"26638071","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI59
Number of Residues	50
Details	Domain: {"description":"Myb-like"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)