9K1T

Crystal structure of mouse granzyme A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0008236	molecular_function	serine-type peptidase activity
A	0009617	biological_process	response to bacterium
A	0030163	biological_process	protein catabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0043065	biological_process	positive regulation of apoptotic process
A	0044194	cellular_component	cytolytic granule
A	0051354	biological_process	negative regulation of oxidoreductase activity
A	0051604	biological_process	protein maturation
A	0070269	biological_process	pyroptotic inflammatory response
A	0140507	biological_process	granzyme-mediated programmed cell death signaling pathway
A	1902483	biological_process	cytotoxic T cell pyroptotic cell death
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0008236	molecular_function	serine-type peptidase activity
B	0009617	biological_process	response to bacterium
B	0030163	biological_process	protein catabolic process
B	0042803	molecular_function	protein homodimerization activity
B	0043065	biological_process	positive regulation of apoptotic process
B	0044194	cellular_component	cytolytic granule
B	0051354	biological_process	negative regulation of oxidoreductase activity
B	0051604	biological_process	protein maturation
B	0070269	biological_process	pyroptotic inflammatory response
B	0140507	biological_process	granzyme-mediated programmed cell death signaling pathway
B	1902483	biological_process	cytotoxic T cell pyroptotic cell death
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0008236	molecular_function	serine-type peptidase activity
C	0009617	biological_process	response to bacterium
C	0030163	biological_process	protein catabolic process
C	0042803	molecular_function	protein homodimerization activity
C	0043065	biological_process	positive regulation of apoptotic process
C	0044194	cellular_component	cytolytic granule
C	0051354	biological_process	negative regulation of oxidoreductase activity
C	0051604	biological_process	protein maturation
C	0070269	biological_process	pyroptotic inflammatory response
C	0140507	biological_process	granzyme-mediated programmed cell death signaling pathway
C	1902483	biological_process	cytotoxic T cell pyroptotic cell death
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0008236	molecular_function	serine-type peptidase activity
D	0009617	biological_process	response to bacterium
D	0030163	biological_process	protein catabolic process
D	0042803	molecular_function	protein homodimerization activity
D	0043065	biological_process	positive regulation of apoptotic process
D	0044194	cellular_component	cytolytic granule
D	0051354	biological_process	negative regulation of oxidoreductase activity
D	0051604	biological_process	protein maturation
D	0070269	biological_process	pyroptotic inflammatory response
D	0140507	biological_process	granzyme-mediated programmed cell death signaling pathway
D	1902483	biological_process	cytotoxic T cell pyroptotic cell death

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU65-CYS70

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScnGDSGSPLL

Chain	Residue	Details
A	ASP205-LEU216

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	684
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"P12544","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---