9JVM

Cryo-EM structure of the receptor of xGPR4-apo in pH8.0

Functional Information from GO Data

Chain	GOid	namespace	contents
R	0004930	molecular_function	G protein-coupled receptor activity
R	0005886	cellular_component	plasma membrane
R	0007165	biological_process	signal transduction
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
R	0010447	biological_process	response to acidic pH
R	0016020	cellular_component	membrane
R	0071468	biological_process	cellular response to acidic pH

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VGAaFLSCVSADRYLaV

Chain	Residue	Details
R	VAL103-VAL119

---

site_id	PS00962
Number of Residues	12
Details	RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. FgFVFYTNLYVG

Chain	Residue	Details
R	PHE93-GLY104

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39753131","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"39753131","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"39753131","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	35
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"39753131","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"39753131","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"39753131","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Required for activation","evidences":[{"source":"UniProtKB","id":"P46093","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Site: {"description":"Proton sensing","evidences":[{"source":"PubMed","id":"39753131","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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