9JTC

Cryo-EM structure of bovine UBA7-UBE2L6-ISG15

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0008641	molecular_function	ubiquitin-like modifier activating enzyme activity
A	0016567	biological_process	protein ubiquitination
A	0016874	molecular_function	ligase activity
A	0032446	biological_process	protein modification by small protein conjugation
A	0036211	biological_process	protein modification process
B	0000166	molecular_function	nucleotide binding
B	0000209	biological_process	protein polyubiquitination
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0016567	biological_process	protein ubiquitination
B	0016740	molecular_function	transferase activity
B	0019787	molecular_function	ubiquitin-like protein transferase activity
B	0032020	biological_process	ISG15-protein conjugation
B	0042296	molecular_function	ISG15 transferase activity
B	0061631	molecular_function	ubiquitin conjugating enzyme activity
C	0002682	biological_process	regulation of immune system process
C	0003735	molecular_function	structural constituent of ribosome
C	0005178	molecular_function	integrin binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0007229	biological_process	integrin-mediated signaling pathway
C	0009615	biological_process	response to virus
C	0019941	biological_process	modification-dependent protein catabolic process
C	0022626	cellular_component	cytosolic ribosome
C	0030501	biological_process	positive regulation of bone mineralization
C	0031386	molecular_function	protein tag activity
C	0031397	biological_process	negative regulation of protein ubiquitination
C	0032020	biological_process	ISG15-protein conjugation
C	0032461	biological_process	positive regulation of protein oligomerization
C	0032649	biological_process	regulation of type II interferon production
C	0032728	biological_process	positive regulation of interferon-beta production
C	0032729	biological_process	positive regulation of type II interferon production
C	0032733	biological_process	positive regulation of interleukin-10 production
C	0034340	biological_process	response to type I interferon
C	0042742	biological_process	defense response to bacterium
C	0045071	biological_process	negative regulation of viral genome replication
C	0045087	biological_process	innate immune response
C	0045648	biological_process	positive regulation of erythrocyte differentiation
C	0051240	biological_process	positive regulation of multicellular organismal process
C	0051607	biological_process	defense response to virus
C	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
C	0070585	biological_process	protein localization to mitochondrion

Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNVdrd.GrVCLpiI

Chain	Residue	Details
B	TYR75-ILE90

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Region: {"description":"Involved in the ligation of specific target proteins"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	5
Details	Motif: {"description":"LRLRGG","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Interacts with activating enzyme","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"Q64339","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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