9JO7

CRP-HCAb4 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001849	molecular_function	complement component C1q complex binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006953	biological_process	acute-phase response
A	0006954	biological_process	inflammatory response
A	0008228	biological_process	opsonization
A	0010628	biological_process	positive regulation of gene expression
A	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
A	0010888	biological_process	negative regulation of lipid storage
A	0030169	molecular_function	low-density lipoprotein particle binding
A	0032677	biological_process	regulation of interleukin-8 production
A	0032930	biological_process	positive regulation of superoxide anion generation
A	0032945	biological_process	negative regulation of mononuclear cell proliferation
A	0033265	molecular_function	choline binding
A	0042310	biological_process	vasoconstriction
A	0042802	molecular_function	identical protein binding
A	0045087	biological_process	innate immune response
A	0046790	molecular_function	virion binding
A	0046872	molecular_function	metal ion binding
A	0050750	molecular_function	low-density lipoprotein particle receptor binding
A	0050830	biological_process	defense response to Gram-positive bacterium
B	0001849	molecular_function	complement component C1q complex binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006953	biological_process	acute-phase response
B	0006954	biological_process	inflammatory response
B	0008228	biological_process	opsonization
B	0010628	biological_process	positive regulation of gene expression
B	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
B	0010888	biological_process	negative regulation of lipid storage
B	0030169	molecular_function	low-density lipoprotein particle binding
B	0032677	biological_process	regulation of interleukin-8 production
B	0032930	biological_process	positive regulation of superoxide anion generation
B	0032945	biological_process	negative regulation of mononuclear cell proliferation
B	0033265	molecular_function	choline binding
B	0042310	biological_process	vasoconstriction
B	0042802	molecular_function	identical protein binding
B	0045087	biological_process	innate immune response
B	0046790	molecular_function	virion binding
B	0046872	molecular_function	metal ion binding
B	0050750	molecular_function	low-density lipoprotein particle receptor binding
B	0050830	biological_process	defense response to Gram-positive bacterium
D	0001849	molecular_function	complement component C1q complex binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006953	biological_process	acute-phase response
D	0006954	biological_process	inflammatory response
D	0008228	biological_process	opsonization
D	0010628	biological_process	positive regulation of gene expression
D	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
D	0010888	biological_process	negative regulation of lipid storage
D	0030169	molecular_function	low-density lipoprotein particle binding
D	0032677	biological_process	regulation of interleukin-8 production
D	0032930	biological_process	positive regulation of superoxide anion generation
D	0032945	biological_process	negative regulation of mononuclear cell proliferation
D	0033265	molecular_function	choline binding
D	0042310	biological_process	vasoconstriction
D	0042802	molecular_function	identical protein binding
D	0045087	biological_process	innate immune response
D	0046790	molecular_function	virion binding
D	0046872	molecular_function	metal ion binding
D	0050750	molecular_function	low-density lipoprotein particle receptor binding
D	0050830	biological_process	defense response to Gram-positive bacterium
F	0001849	molecular_function	complement component C1q complex binding
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0006953	biological_process	acute-phase response
F	0006954	biological_process	inflammatory response
F	0008228	biological_process	opsonization
F	0010628	biological_process	positive regulation of gene expression
F	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
F	0010888	biological_process	negative regulation of lipid storage
F	0030169	molecular_function	low-density lipoprotein particle binding
F	0032677	biological_process	regulation of interleukin-8 production
F	0032930	biological_process	positive regulation of superoxide anion generation
F	0032945	biological_process	negative regulation of mononuclear cell proliferation
F	0033265	molecular_function	choline binding
F	0042310	biological_process	vasoconstriction
F	0042802	molecular_function	identical protein binding
F	0045087	biological_process	innate immune response
F	0046790	molecular_function	virion binding
F	0046872	molecular_function	metal ion binding
F	0050750	molecular_function	low-density lipoprotein particle receptor binding
F	0050830	biological_process	defense response to Gram-positive bacterium
H	0001849	molecular_function	complement component C1q complex binding
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0006953	biological_process	acute-phase response
H	0006954	biological_process	inflammatory response
H	0008228	biological_process	opsonization
H	0010628	biological_process	positive regulation of gene expression
H	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
H	0010888	biological_process	negative regulation of lipid storage
H	0030169	molecular_function	low-density lipoprotein particle binding
H	0032677	biological_process	regulation of interleukin-8 production
H	0032930	biological_process	positive regulation of superoxide anion generation
H	0032945	biological_process	negative regulation of mononuclear cell proliferation
H	0033265	molecular_function	choline binding
H	0042310	biological_process	vasoconstriction
H	0042802	molecular_function	identical protein binding
H	0045087	biological_process	innate immune response
H	0046790	molecular_function	virion binding
H	0046872	molecular_function	metal ion binding
H	0050750	molecular_function	low-density lipoprotein particle receptor binding
H	0050830	biological_process	defense response to Gram-positive bacterium

Functional Information from PROSITE/UniProt

site_id	PS00289
Number of Residues	8
Details	PTX_1 Pentraxin domain signature. HiCtSWeS

Chain	Residue	Details
A	HIS95-SER102

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1005
Details	Domain: {"description":"Pentraxin (PTX)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01172","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01172","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	5
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"762075","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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