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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9JO3

Cryo-EM structure of human BKca channel-compound 10b complex

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0003779molecular_functionactin binding
A0005249molecular_functionvoltage-gated potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006970biological_processresponse to osmotic stress
A0008076cellular_componentvoltage-gated potassium channel complex
A0015269molecular_functioncalcium-activated potassium channel activity
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0030007biological_processintracellular potassium ion homeostasis
A0034220biological_processmonoatomic ion transmembrane transport
A0034465biological_processresponse to carbon monoxide
A0034702cellular_componentmonoatomic ion channel complex
A0042311biological_processvasodilation
A0042391biological_processregulation of membrane potential
A0043065biological_processpositive regulation of apoptotic process
A0045211cellular_componentpostsynaptic membrane
A0045794biological_processnegative regulation of cell volume
A0046872molecular_functionmetal ion binding
A0051592biological_processresponse to calcium ion
A0060072molecular_functionlarge conductance calcium-activated potassium channel activity
A0060073biological_processmicturition
A0060083biological_processsmooth muscle contraction involved in micturition
A0071805biological_processpotassium ion transmembrane transport
B0001666biological_processresponse to hypoxia
B0003779molecular_functionactin binding
B0005249molecular_functionvoltage-gated potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005901cellular_componentcaveola
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006970biological_processresponse to osmotic stress
B0008076cellular_componentvoltage-gated potassium channel complex
B0015269molecular_functioncalcium-activated potassium channel activity
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0030007biological_processintracellular potassium ion homeostasis
B0034220biological_processmonoatomic ion transmembrane transport
B0034465biological_processresponse to carbon monoxide
B0034702cellular_componentmonoatomic ion channel complex
B0042311biological_processvasodilation
B0042391biological_processregulation of membrane potential
B0043065biological_processpositive regulation of apoptotic process
B0045211cellular_componentpostsynaptic membrane
B0045794biological_processnegative regulation of cell volume
B0046872molecular_functionmetal ion binding
B0051592biological_processresponse to calcium ion
B0060072molecular_functionlarge conductance calcium-activated potassium channel activity
B0060073biological_processmicturition
B0060083biological_processsmooth muscle contraction involved in micturition
B0071805biological_processpotassium ion transmembrane transport
C0001666biological_processresponse to hypoxia
C0003779molecular_functionactin binding
C0005249molecular_functionvoltage-gated potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0005901cellular_componentcaveola
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0006970biological_processresponse to osmotic stress
C0008076cellular_componentvoltage-gated potassium channel complex
C0015269molecular_functioncalcium-activated potassium channel activity
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0030007biological_processintracellular potassium ion homeostasis
C0034220biological_processmonoatomic ion transmembrane transport
C0034465biological_processresponse to carbon monoxide
C0034702cellular_componentmonoatomic ion channel complex
C0042311biological_processvasodilation
C0042391biological_processregulation of membrane potential
C0043065biological_processpositive regulation of apoptotic process
C0045211cellular_componentpostsynaptic membrane
C0045794biological_processnegative regulation of cell volume
C0046872molecular_functionmetal ion binding
C0051592biological_processresponse to calcium ion
C0060072molecular_functionlarge conductance calcium-activated potassium channel activity
C0060073biological_processmicturition
C0060083biological_processsmooth muscle contraction involved in micturition
C0071805biological_processpotassium ion transmembrane transport
D0001666biological_processresponse to hypoxia
D0003779molecular_functionactin binding
D0005249molecular_functionvoltage-gated potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0005901cellular_componentcaveola
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006970biological_processresponse to osmotic stress
D0008076cellular_componentvoltage-gated potassium channel complex
D0015269molecular_functioncalcium-activated potassium channel activity
D0016020cellular_componentmembrane
D0016324cellular_componentapical plasma membrane
D0030007biological_processintracellular potassium ion homeostasis
D0034220biological_processmonoatomic ion transmembrane transport
D0034465biological_processresponse to carbon monoxide
D0034702cellular_componentmonoatomic ion channel complex
D0042311biological_processvasodilation
D0042391biological_processregulation of membrane potential
D0043065biological_processpositive regulation of apoptotic process
D0045211cellular_componentpostsynaptic membrane
D0045794biological_processnegative regulation of cell volume
D0046872molecular_functionmetal ion binding
D0051592biological_processresponse to calcium ion
D0060072molecular_functionlarge conductance calcium-activated potassium channel activity
D0060073biological_processmicturition
D0060083biological_processsmooth muscle contraction involved in micturition
D0071805biological_processpotassium ion transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00092
Number of Residues7
DetailsN6_MTASE N-6 Adenine-specific DNA methylases signature. VITNPPY
ChainResidueDetails
AVAL1091-TYR1097
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S0","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues152
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues68
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues88
DetailsIntramembrane: {"description":"Pore-forming; Name=P region","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues568
DetailsDomain: {"description":"RCK N-terminal 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00543","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues80
DetailsRegion: {"description":"Segment S7"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues80
DetailsRegion: {"description":"Segment S8"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues16
DetailsRegion: {"description":"Heme-binding motif","evidences":[{"source":"PubMed","id":"14523450","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues80
DetailsRegion: {"description":"Segment S9"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues80
DetailsRegion: {"description":"Segment S10"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues12
DetailsMotif: {"description":"Selectivity for potassium"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues88
DetailsMotif: {"description":"Calcium bowl","evidences":[{"source":"UniProtKB","id":"B7ZC96","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues12
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"B7ZC96","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2025-10-08

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