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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9JJE

Nematostella vectensis TRPM2 tetramer in complex with ADPRP/Ca2+

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005262molecular_functioncalcium channel activity
A0005272molecular_functionsodium channel activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006814biological_processsodium ion transport
A0006816biological_processcalcium ion transport
A0015280molecular_functionligand-gated sodium channel activity
A0016020cellular_componentmembrane
A0019722biological_processcalcium-mediated signaling
A0030001biological_processmetal ion transport
A0034220biological_processmonoatomic ion transmembrane transport
A0035725biological_processsodium ion transmembrane transport
A0046872molecular_functionmetal ion binding
A0047631molecular_functionADP-ribose diphosphatase activity
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0098662biological_processinorganic cation transmembrane transport
A0099604molecular_functionligand-gated calcium channel activity
B0005216molecular_functionmonoatomic ion channel activity
B0005262molecular_functioncalcium channel activity
B0005272molecular_functionsodium channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006814biological_processsodium ion transport
B0006816biological_processcalcium ion transport
B0015280molecular_functionligand-gated sodium channel activity
B0016020cellular_componentmembrane
B0019722biological_processcalcium-mediated signaling
B0030001biological_processmetal ion transport
B0034220biological_processmonoatomic ion transmembrane transport
B0035725biological_processsodium ion transmembrane transport
B0046872molecular_functionmetal ion binding
B0047631molecular_functionADP-ribose diphosphatase activity
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0098662biological_processinorganic cation transmembrane transport
B0099604molecular_functionligand-gated calcium channel activity
C0005216molecular_functionmonoatomic ion channel activity
C0005262molecular_functioncalcium channel activity
C0005272molecular_functionsodium channel activity
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006814biological_processsodium ion transport
C0006816biological_processcalcium ion transport
C0015280molecular_functionligand-gated sodium channel activity
C0016020cellular_componentmembrane
C0019722biological_processcalcium-mediated signaling
C0030001biological_processmetal ion transport
C0034220biological_processmonoatomic ion transmembrane transport
C0035725biological_processsodium ion transmembrane transport
C0046872molecular_functionmetal ion binding
C0047631molecular_functionADP-ribose diphosphatase activity
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0098662biological_processinorganic cation transmembrane transport
C0099604molecular_functionligand-gated calcium channel activity
D0005216molecular_functionmonoatomic ion channel activity
D0005262molecular_functioncalcium channel activity
D0005272molecular_functionsodium channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006814biological_processsodium ion transport
D0006816biological_processcalcium ion transport
D0015280molecular_functionligand-gated sodium channel activity
D0016020cellular_componentmembrane
D0019722biological_processcalcium-mediated signaling
D0030001biological_processmetal ion transport
D0034220biological_processmonoatomic ion transmembrane transport
D0035725biological_processsodium ion transmembrane transport
D0046872molecular_functionmetal ion binding
D0047631molecular_functionADP-ribose diphosphatase activity
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
D0098662biological_processinorganic cation transmembrane transport
D0099604molecular_functionligand-gated calcium channel activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues60
DetailsIntramembrane: {"evidences":[{"source":"UniProtKB","id":"O94759","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues480
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29745897","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues268
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues252
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues60
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"29745897","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"29745897","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues8
DetailsMotif: {"description":"Prevents fast channel inactivation","evidences":[{"source":"PubMed","id":"29745897","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29745897","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CO7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29745897","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CO7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2025-07-30

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