9JJE

Nematostella vectensis TRPM2 tetramer in complex with ADPRP/Ca2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0015075	molecular_function	monoatomic ion transmembrane transporter activity
A	0015280	molecular_function	ligand-gated sodium channel activity
A	0019722	biological_process	calcium-mediated signaling
A	0030001	biological_process	metal ion transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0047631	molecular_function	ADP-ribose diphosphatase activity
A	0070588	biological_process	calcium ion transmembrane transport
A	0099604	molecular_function	ligand-gated calcium channel activity
B	0005886	cellular_component	plasma membrane
B	0015075	molecular_function	monoatomic ion transmembrane transporter activity
B	0015280	molecular_function	ligand-gated sodium channel activity
B	0019722	biological_process	calcium-mediated signaling
B	0030001	biological_process	metal ion transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0047631	molecular_function	ADP-ribose diphosphatase activity
B	0070588	biological_process	calcium ion transmembrane transport
B	0099604	molecular_function	ligand-gated calcium channel activity
C	0005886	cellular_component	plasma membrane
C	0015075	molecular_function	monoatomic ion transmembrane transporter activity
C	0015280	molecular_function	ligand-gated sodium channel activity
C	0019722	biological_process	calcium-mediated signaling
C	0030001	biological_process	metal ion transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0047631	molecular_function	ADP-ribose diphosphatase activity
C	0070588	biological_process	calcium ion transmembrane transport
C	0099604	molecular_function	ligand-gated calcium channel activity
D	0005886	cellular_component	plasma membrane
D	0015075	molecular_function	monoatomic ion transmembrane transporter activity
D	0015280	molecular_function	ligand-gated sodium channel activity
D	0019722	biological_process	calcium-mediated signaling
D	0030001	biological_process	metal ion transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0047631	molecular_function	ADP-ribose diphosphatase activity
D	0070588	biological_process	calcium ion transmembrane transport
D	0099604	molecular_function	ligand-gated calcium channel activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Intramembrane: {"evidences":[{"source":"UniProtKB","id":"O94759","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	480
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29745897","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	268
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	252
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	60
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"29745897","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"29745897","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Motif: {"description":"Prevents fast channel inactivation","evidences":[{"source":"PubMed","id":"29745897","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29745897","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CO7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29745897","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CO7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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