9JJ3

Cryo-EM structure of human ZnT4 D150N/D281N

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005385	molecular_function	zinc ion transmembrane transporter activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005765	cellular_component	lysosomal membrane
A	0005770	cellular_component	late endosome
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0006829	biological_process	zinc ion transport
A	0008324	molecular_function	monoatomic cation transmembrane transporter activity
A	0009636	biological_process	response to toxic substance
A	0010008	cellular_component	endosome membrane
A	0010043	biological_process	response to zinc ion
A	0012506	cellular_component	vesicle membrane
A	0015297	molecular_function	antiporter activity
A	0016020	cellular_component	membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0031902	cellular_component	late endosome membrane
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0062111	biological_process	zinc ion import into organelle
A	0071577	biological_process	zinc ion transmembrane transport
A	0140916	biological_process	zinc ion import into lysosome
B	0005385	molecular_function	zinc ion transmembrane transporter activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005765	cellular_component	lysosomal membrane
B	0005770	cellular_component	late endosome
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0006829	biological_process	zinc ion transport
B	0008324	molecular_function	monoatomic cation transmembrane transporter activity
B	0009636	biological_process	response to toxic substance
B	0010008	cellular_component	endosome membrane
B	0010043	biological_process	response to zinc ion
B	0012506	cellular_component	vesicle membrane
B	0015297	molecular_function	antiporter activity
B	0016020	cellular_component	membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0031902	cellular_component	late endosome membrane
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0062111	biological_process	zinc ion import into organelle
B	0071577	biological_process	zinc ion transmembrane transport
B	0140916	biological_process	zinc ion import into lysosome

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	76
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	26
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8IWU4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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