Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9JGZ

Cryo-EM Structure of Human Kcnk13.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005267	molecular_function	potassium channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0015271	molecular_function	outward rectifier potassium channel activity
A	0016020	cellular_component	membrane
A	0022841	molecular_function	potassium ion leak channel activity
A	0042802	molecular_function	identical protein binding
A	0046982	molecular_function	protein heterodimerization activity
A	0060075	biological_process	regulation of resting membrane potential
A	0071805	biological_process	potassium ion transmembrane transport
A	1900225	biological_process	regulation of NLRP3 inflammasome complex assembly
A	1905810	biological_process	regulation of excitatory synapse pruning
B	0005267	molecular_function	potassium channel activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0015271	molecular_function	outward rectifier potassium channel activity
B	0016020	cellular_component	membrane
B	0022841	molecular_function	potassium ion leak channel activity
B	0042802	molecular_function	identical protein binding
B	0046982	molecular_function	protein heterodimerization activity
B	0060075	biological_process	regulation of resting membrane potential
B	0071805	biological_process	potassium ion transmembrane transport
B	1900225	biological_process	regulation of NLRP3 inflammasome complex assembly
B	1905810	biological_process	regulation of excitatory synapse pruning

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=M1","evidences":[{"source":"PubMed","id":"40011745","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40011746","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40178898","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40307591","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9C07","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9C09","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9FT7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9JGZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9JH1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	244
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"40011745","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40011746","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40178898","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40307591","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9C07","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9C09","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9FT7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9JGZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9JH1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=M2","evidences":[{"source":"PubMed","id":"40011745","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40011746","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40178898","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40307591","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9C07","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9C09","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9FT7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9JGZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9JH1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=M3","evidences":[{"source":"PubMed","id":"40011745","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40011746","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40178898","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40307591","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9C07","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9C09","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9FT7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9JGZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9JH1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=M4","evidences":[{"source":"PubMed","id":"40011745","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40011746","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40178898","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40307591","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9C07","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9C09","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9FT7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9JGZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9JH1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	10
Details	Region: {"description":"Selectivity filter 1","evidences":[{"source":"PubMed","id":"40011745","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40011746","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40178898","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40307591","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9C07","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9C09","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9FT7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9JGZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	10
Details	Region: {"description":"Selectivity filter 2","evidences":[{"source":"PubMed","id":"40011745","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40011746","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40178898","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40307591","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9C07","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9C09","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9FT7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9JGZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"40011745","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40011746","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40178898","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40307591","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9C07","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9C09","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9FT7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9JGZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)