9JB2

Cryo-EM structure of the type II amyloid-beta 42 fibril containing a D-Asp at positions 7 and 23

This is a non-PDB format compatible entry.

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943

Chain	Residue	Details
C	HIS6
E	HIS14
CC	HIS6
CC	HIS14
BE	HIS6
BE	HIS14
BD	HIS6
BD	HIS14
BC	HIS6
BC	HIS14
BB	HIS6
C	HIS14
BB	HIS14
BA	HIS6
BA	HIS14
CB	HIS6
CB	HIS14
CA	HIS6
CA	HIS14
CD	HIS6
CD	HIS14
CE	HIS6
A	HIS6
CE	HIS14
A	HIS14
B	HIS6
B	HIS14
D	HIS6
D	HIS14
E	HIS6

---

site_id	SWS_FT_FI2
Number of Residues	15
Details	BINDING: BINDING => ECO:0000305|PubMed:10413512, ECO:0000305|PubMed:11274207

Chain	Residue	Details
C	TYR10
BB	TYR10
BA	TYR10
CB	TYR10
CA	TYR10
CD	TYR10
CE	TYR10
A	TYR10
B	TYR10
D	TYR10
E	TYR10
CC	TYR10
BE	TYR10
BD	TYR10
BC	TYR10

---

site_id	SWS_FT_FI3
Number of Residues	15
Details	BINDING: BINDING => ECO:0000269|PubMed:10413512, ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943

Chain	Residue	Details
C	HIS13
BB	HIS13
BA	HIS13
CB	HIS13
CA	HIS13
CD	HIS13
CE	HIS13
A	HIS13
B	HIS13
D	HIS13
E	HIS13
CC	HIS13
BE	HIS13
BD	HIS13
BC	HIS13

---

site_id	SWS_FT_FI4
Number of Residues	15
Details	SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671

Chain	Residue	Details
C	ASP1
BB	ASP1
BA	ASP1
CB	ASP1
CA	ASP1
CD	ASP1
CE	ASP1
A	ASP1
B	ASP1
D	ASP1
E	ASP1
CC	ASP1
BE	ASP1
BD	ASP1
BC	ASP1

---

site_id	SWS_FT_FI5
Number of Residues	15
Details	SITE: Cleavage; by ACE => ECO:0000269|PubMed:11604391, ECO:0000269|PubMed:16154999

Chain	Residue	Details
C	DAS7
BB	DAS7
BA	DAS7
CB	DAS7
CA	DAS7
CD	DAS7
CE	DAS7
A	DAS7
B	DAS7
D	DAS7
E	DAS7
CC	DAS7
BE	DAS7
BD	DAS7
BC	DAS7

---

site_id	SWS_FT_FI6
Number of Residues	15
Details	SITE: Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430

Chain	Residue	Details
C	LYS16
BB	LYS16
BA	LYS16
CB	LYS16
CA	LYS16
CD	LYS16
CE	LYS16
A	LYS16
B	LYS16
D	LYS16
E	LYS16
CC	LYS16
BE	LYS16
BD	LYS16
BC	LYS16

---

site_id	SWS_FT_FI7
Number of Residues	15
Details	SITE: Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112

Chain	Residue	Details
C	PHE19
BB	PHE19
BA	PHE19
CB	PHE19
CA	PHE19
CD	PHE19
CE	PHE19
A	PHE19
B	PHE19
D	PHE19
E	PHE19
CC	PHE19
BE	PHE19
BD	PHE19
BC	PHE19

---

site_id	SWS_FT_FI8
Number of Residues	15
Details	SITE: Implicated in free radical propagation => ECO:0000250

Chain	Residue	Details
C	GLY33
BB	GLY33
BA	GLY33
CB	GLY33
CA	GLY33
CD	GLY33
CE	GLY33
A	GLY33
B	GLY33
D	GLY33
E	GLY33
CC	GLY33
BE	GLY33
BD	GLY33
BC	GLY33

---

site_id	SWS_FT_FI9
Number of Residues	15
Details	SITE: Susceptible to oxidation => ECO:0000269|PubMed:10535332

Chain	Residue	Details
C	MET35
BB	MET35
BA	MET35
CB	MET35
CA	MET35
CD	MET35
CE	MET35
A	MET35
B	MET35
D	MET35
E	MET35
CC	MET35
BE	MET35
BD	MET35
BC	MET35

---

site_id	SWS_FT_FI10
Number of Residues	15
Details	SITE: Cleavage; by gamma-secretase; site 1 => ECO:0000305|PubMed:11851430

Chain	Residue	Details
C	VAL40
BB	VAL40
BA	VAL40
CB	VAL40
CA	VAL40
CD	VAL40
CE	VAL40
A	VAL40
B	VAL40
D	VAL40
E	VAL40
CC	VAL40
BE	VAL40
BD	VAL40
BC	VAL40

---

site_id	SWS_FT_FI11
Number of Residues	15
Details	SITE: Cleavage; by gamma-secretase; site 2 => ECO:0000305|PubMed:11851430

Chain	Residue	Details
C	ALA42
BB	ALA42
BA	ALA42
CB	ALA42
CA	ALA42
CD	ALA42
CE	ALA42
A	ALA42
B	ALA42
D	ALA42
E	ALA42
CC	ALA42
BE	ALA42
BD	ALA42
BC	ALA42

---

site_id	SWS_FT_FI12
Number of Residues	15
Details	CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269|PubMed:22576872

Chain	Residue	Details
C	TYR10
BB	TYR10
BA	TYR10
CB	TYR10
CA	TYR10
CD	TYR10
CE	TYR10
A	TYR10
B	TYR10
D	TYR10
E	TYR10
CC	TYR10
BE	TYR10
BD	TYR10
BC	TYR10

---