9JB2
Cryo-EM structure of the type II amyloid-beta 42 fibril containing a D-Asp at positions 7 and 23
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
| B | 0016020 | cellular_component | membrane |
| BA | 0016020 | cellular_component | membrane |
| BB | 0016020 | cellular_component | membrane |
| BC | 0016020 | cellular_component | membrane |
| BD | 0016020 | cellular_component | membrane |
| BE | 0016020 | cellular_component | membrane |
| C | 0016020 | cellular_component | membrane |
| CA | 0016020 | cellular_component | membrane |
| CB | 0016020 | cellular_component | membrane |
| CC | 0016020 | cellular_component | membrane |
| CD | 0016020 | cellular_component | membrane |
| CE | 0016020 | cellular_component | membrane |
| D | 0016020 | cellular_component | membrane |
| E | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10413512","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11274207","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 15 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10413512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11274207","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26898943","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11274207","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26898943","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 15 |
| Details | Site: {"description":"Cleavage; by alpha-secretase","evidences":[{"source":"PubMed","id":"11851430","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 15 |
| Details | Site: {"description":"Cleavage; by theta-secretase","evidences":[{"source":"PubMed","id":"16816112","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 15 |
| Details | Site: {"description":"Implicated in free radical propagation","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | Glycosylation: {"description":"O-linked (HexNAc...) tyrosine; partial","evidences":[{"source":"PubMed","id":"22576872","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 5 |
| Details | Site: {"description":"Cleavage; by caspase-6; when associated with variant 670-N-L-671"} |
| Chain | Residue | Details |
