9JB1
Cryo-EM structure of the type I amyloid-beta 42 fibril containing a D-Asp at positions 7 and 23
This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| FO | HIS6 | |
| FL | HIS14 | |
| FQ | HIS6 | |
| FQ | HIS14 | |
| FK | HIS6 | |
| FK | HIS14 | |
| FJ | HIS6 | |
| FJ | HIS14 | |
| FI | HIS6 | |
| FI | HIS14 | |
| FH | HIS6 | |
| FO | HIS14 | |
| FH | HIS14 | |
| FG | HIS6 | |
| FG | HIS14 | |
| FF | HIS6 | |
| FF | HIS14 | |
| FP | HIS6 | |
| FP | HIS14 | |
| FN | HIS6 | |
| FN | HIS14 | |
| FM | HIS6 | |
| FM | HIS14 | |
| FL | HIS6 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:10413512, ECO:0000305|PubMed:11274207 |
| Chain | Residue | Details |
| FO | TYR10 | |
| FH | TYR10 | |
| FG | TYR10 | |
| FF | TYR10 | |
| FP | TYR10 | |
| FN | TYR10 | |
| FM | TYR10 | |
| FL | TYR10 | |
| FQ | TYR10 | |
| FK | TYR10 | |
| FJ | TYR10 | |
| FI | TYR10 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10413512, ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| FO | HIS13 | |
| FH | HIS13 | |
| FG | HIS13 | |
| FF | HIS13 | |
| FP | HIS13 | |
| FN | HIS13 | |
| FM | HIS13 | |
| FL | HIS13 | |
| FQ | HIS13 | |
| FK | HIS13 | |
| FJ | HIS13 | |
| FI | HIS13 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671 |
| Chain | Residue | Details |
| FO | ASP1 | |
| FH | ASP1 | |
| FG | ASP1 | |
| FF | ASP1 | |
| FP | ASP1 | |
| FN | ASP1 | |
| FM | ASP1 | |
| FL | ASP1 | |
| FQ | ASP1 | |
| FK | ASP1 | |
| FJ | ASP1 | |
| FI | ASP1 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | SITE: Cleavage; by ACE => ECO:0000269|PubMed:11604391, ECO:0000269|PubMed:16154999 |
| Chain | Residue | Details |
| FO | ASP7 | |
| FH | ASP7 | |
| FG | ASP7 | |
| FF | ASP7 | |
| FP | ASP7 | |
| FN | ASP7 | |
| FM | ASP7 | |
| FL | ASP7 | |
| FQ | ASP7 | |
| FK | ASP7 | |
| FJ | ASP7 | |
| FI | ASP7 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | SITE: Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| FO | LYS16 | |
| FH | LYS16 | |
| FG | LYS16 | |
| FF | LYS16 | |
| FP | LYS16 | |
| FN | LYS16 | |
| FM | LYS16 | |
| FL | LYS16 | |
| FQ | LYS16 | |
| FK | LYS16 | |
| FJ | LYS16 | |
| FI | LYS16 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | SITE: Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112 |
| Chain | Residue | Details |
| FO | PHE19 | |
| FH | PHE19 | |
| FG | PHE19 | |
| FF | PHE19 | |
| FP | PHE19 | |
| FN | PHE19 | |
| FM | PHE19 | |
| FL | PHE19 | |
| FQ | PHE19 | |
| FK | PHE19 | |
| FJ | PHE19 | |
| FI | PHE19 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | SITE: Implicated in free radical propagation => ECO:0000250 |
| Chain | Residue | Details |
| FO | GLY33 | |
| FH | GLY33 | |
| FG | GLY33 | |
| FF | GLY33 | |
| FP | GLY33 | |
| FN | GLY33 | |
| FM | GLY33 | |
| FL | GLY33 | |
| FQ | GLY33 | |
| FK | GLY33 | |
| FJ | GLY33 | |
| FI | GLY33 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 12 |
| Details | SITE: Susceptible to oxidation => ECO:0000269|PubMed:10535332 |
| Chain | Residue | Details |
| FO | MET35 | |
| FH | MET35 | |
| FG | MET35 | |
| FF | MET35 | |
| FP | MET35 | |
| FN | MET35 | |
| FM | MET35 | |
| FL | MET35 | |
| FQ | MET35 | |
| FK | MET35 | |
| FJ | MET35 | |
| FI | MET35 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | SITE: Cleavage; by gamma-secretase; site 1 => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| FO | VAL40 | |
| FH | VAL40 | |
| FG | VAL40 | |
| FF | VAL40 | |
| FP | VAL40 | |
| FN | VAL40 | |
| FM | VAL40 | |
| FL | VAL40 | |
| FQ | VAL40 | |
| FK | VAL40 | |
| FJ | VAL40 | |
| FI | VAL40 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 12 |
| Details | SITE: Cleavage; by gamma-secretase; site 2 => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| FO | ALA42 | |
| FH | ALA42 | |
| FG | ALA42 | |
| FF | ALA42 | |
| FP | ALA42 | |
| FN | ALA42 | |
| FM | ALA42 | |
| FL | ALA42 | |
| FQ | ALA42 | |
| FK | ALA42 | |
| FJ | ALA42 | |
| FI | ALA42 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 12 |
| Details | CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269|PubMed:22576872 |
| Chain | Residue | Details |
| FO | TYR10 | |
| FH | TYR10 | |
| FG | TYR10 | |
| FF | TYR10 | |
| FP | TYR10 | |
| FN | TYR10 | |
| FM | TYR10 | |
| FL | TYR10 | |
| FQ | TYR10 | |
| FK | TYR10 | |
| FJ | TYR10 | |
| FI | TYR10 |
