9JB0
Cryo-EM structure of the class II amyloid-beta 42 fibril containing a D-Asp at position 23
This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| CC | HIS6 | |
| FF | HIS14 | |
| AA | HIS6 | |
| AA | HIS14 | |
| A | HIS6 | |
| A | HIS14 | |
| B | HIS6 | |
| B | HIS14 | |
| C | HIS6 | |
| C | HIS14 | |
| D | HIS6 | |
| CC | HIS14 | |
| D | HIS14 | |
| E | HIS6 | |
| E | HIS14 | |
| F | HIS6 | |
| F | HIS14 | |
| BB | HIS6 | |
| BB | HIS14 | |
| DD | HIS6 | |
| DD | HIS14 | |
| EE | HIS6 | |
| EE | HIS14 | |
| FF | HIS6 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:10413512, ECO:0000305|PubMed:11274207 |
| Chain | Residue | Details |
| CC | TYR10 | |
| D | TYR10 | |
| E | TYR10 | |
| F | TYR10 | |
| BB | TYR10 | |
| DD | TYR10 | |
| EE | TYR10 | |
| FF | TYR10 | |
| AA | TYR10 | |
| A | TYR10 | |
| B | TYR10 | |
| C | TYR10 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10413512, ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| CC | HIS13 | |
| D | HIS13 | |
| E | HIS13 | |
| F | HIS13 | |
| BB | HIS13 | |
| DD | HIS13 | |
| EE | HIS13 | |
| FF | HIS13 | |
| AA | HIS13 | |
| A | HIS13 | |
| B | HIS13 | |
| C | HIS13 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671 |
| Chain | Residue | Details |
| CC | ASP1 | |
| D | ASP1 | |
| E | ASP1 | |
| F | ASP1 | |
| BB | ASP1 | |
| DD | ASP1 | |
| EE | ASP1 | |
| FF | ASP1 | |
| AA | ASP1 | |
| A | ASP1 | |
| B | ASP1 | |
| C | ASP1 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | SITE: Cleavage; by ACE => ECO:0000269|PubMed:11604391, ECO:0000269|PubMed:16154999 |
| Chain | Residue | Details |
| CC | ASP7 | |
| D | ASP7 | |
| E | ASP7 | |
| F | ASP7 | |
| BB | ASP7 | |
| DD | ASP7 | |
| EE | ASP7 | |
| FF | ASP7 | |
| AA | ASP7 | |
| A | ASP7 | |
| B | ASP7 | |
| C | ASP7 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | SITE: Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| CC | LYS16 | |
| D | LYS16 | |
| E | LYS16 | |
| F | LYS16 | |
| BB | LYS16 | |
| DD | LYS16 | |
| EE | LYS16 | |
| FF | LYS16 | |
| AA | LYS16 | |
| A | LYS16 | |
| B | LYS16 | |
| C | LYS16 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | SITE: Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112 |
| Chain | Residue | Details |
| CC | PHE19 | |
| D | PHE19 | |
| E | PHE19 | |
| F | PHE19 | |
| BB | PHE19 | |
| DD | PHE19 | |
| EE | PHE19 | |
| FF | PHE19 | |
| AA | PHE19 | |
| A | PHE19 | |
| B | PHE19 | |
| C | PHE19 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | SITE: Implicated in free radical propagation => ECO:0000250 |
| Chain | Residue | Details |
| CC | GLY33 | |
| D | GLY33 | |
| E | GLY33 | |
| F | GLY33 | |
| BB | GLY33 | |
| DD | GLY33 | |
| EE | GLY33 | |
| FF | GLY33 | |
| AA | GLY33 | |
| A | GLY33 | |
| B | GLY33 | |
| C | GLY33 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 12 |
| Details | SITE: Susceptible to oxidation => ECO:0000269|PubMed:10535332 |
| Chain | Residue | Details |
| CC | MET35 | |
| D | MET35 | |
| E | MET35 | |
| F | MET35 | |
| BB | MET35 | |
| DD | MET35 | |
| EE | MET35 | |
| FF | MET35 | |
| AA | MET35 | |
| A | MET35 | |
| B | MET35 | |
| C | MET35 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | SITE: Cleavage; by gamma-secretase; site 1 => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| CC | VAL40 | |
| D | VAL40 | |
| E | VAL40 | |
| F | VAL40 | |
| BB | VAL40 | |
| DD | VAL40 | |
| EE | VAL40 | |
| FF | VAL40 | |
| AA | VAL40 | |
| A | VAL40 | |
| B | VAL40 | |
| C | VAL40 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 12 |
| Details | SITE: Cleavage; by gamma-secretase; site 2 => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| CC | ALA42 | |
| D | ALA42 | |
| E | ALA42 | |
| F | ALA42 | |
| BB | ALA42 | |
| DD | ALA42 | |
| EE | ALA42 | |
| FF | ALA42 | |
| AA | ALA42 | |
| A | ALA42 | |
| B | ALA42 | |
| C | ALA42 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 12 |
| Details | CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269|PubMed:22576872 |
| Chain | Residue | Details |
| CC | TYR10 | |
| D | TYR10 | |
| E | TYR10 | |
| F | TYR10 | |
| BB | TYR10 | |
| DD | TYR10 | |
| EE | TYR10 | |
| FF | TYR10 | |
| AA | TYR10 | |
| A | TYR10 | |
| B | TYR10 | |
| C | TYR10 |
