9J8D
Human Glycine Transporter 1 in the Iclepertin-Bound State with an Inward-Facing Conformation
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001504 | biological_process | neurotransmitter uptake |
| A | 0005283 | molecular_function | amino acid:sodium symporter activity |
| A | 0005768 | cellular_component | endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006836 | biological_process | neurotransmitter transport |
| A | 0006865 | biological_process | amino acid transport |
| A | 0009925 | cellular_component | basal plasma membrane |
| A | 0014069 | cellular_component | postsynaptic density |
| A | 0015187 | molecular_function | glycine transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015375 | molecular_function | glycine:sodium symporter activity |
| A | 0015816 | biological_process | glycine transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016328 | cellular_component | lateral plasma membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030672 | cellular_component | synaptic vesicle membrane |
| A | 0031045 | cellular_component | dense core granule |
| A | 0032279 | cellular_component | asymmetric synapse |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042734 | cellular_component | presynaptic membrane |
| A | 0045211 | cellular_component | postsynaptic membrane |
| A | 0046985 | biological_process | positive regulation of hemoglobin biosynthetic process |
| A | 0060092 | biological_process | regulation of synaptic transmission, glycinergic |
| A | 0061537 | biological_process | glycine secretion, neurotransmission |
| A | 0070455 | biological_process | positive regulation of heme biosynthetic process |
| A | 0098686 | cellular_component | hippocampal mossy fiber to CA3 synapse |
| A | 0098688 | cellular_component | parallel fiber to Purkinje cell synapse |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1903804 | biological_process | glycine import across plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00610 |
| Number of Residues | 15 |
| Details | NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcyrNGGGaF |
| Chain | Residue | Details |
| A | TRP70-PHE84 |
| site_id | PS00754 |
| Number of Residues | 21 |
| Details | NA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. YFfsSMThvLPWayCnnpwNT |
| Chain | Residue | Details |
| A | TYR152-THR172 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=10","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=11","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=12","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
