Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9J7B

local refinement of FEM1B bound with TOM20(tetramer)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000151	cellular_component	ubiquitin ligase complex
A	0002070	biological_process	epithelial cell maturation
A	0005123	molecular_function	death receptor binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006915	biological_process	apoptotic process
A	0016567	biological_process	protein ubiquitination
A	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0046872	molecular_function	metal ion binding
A	0051438	biological_process	regulation of ubiquitin-protein transferase activity
A	0060442	biological_process	branching involved in prostate gland morphogenesis
A	0060743	biological_process	epithelial cell maturation involved in prostate gland development
A	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
A	1902041	biological_process	regulation of extrinsic apoptotic signaling pathway via death domain receptors
A	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
A	2000001	biological_process	regulation of DNA damage checkpoint
J	0000151	cellular_component	ubiquitin ligase complex
J	0002070	biological_process	epithelial cell maturation
J	0005123	molecular_function	death receptor binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005829	cellular_component	cytosol
J	0006915	biological_process	apoptotic process
J	0016567	biological_process	protein ubiquitination
J	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0046872	molecular_function	metal ion binding
J	0051438	biological_process	regulation of ubiquitin-protein transferase activity
J	0060442	biological_process	branching involved in prostate gland morphogenesis
J	0060743	biological_process	epithelial cell maturation involved in prostate gland development
J	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
J	1902041	biological_process	regulation of extrinsic apoptotic signaling pathway via death domain receptors
J	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
J	2000001	biological_process	regulation of DNA damage checkpoint
O	0000151	cellular_component	ubiquitin ligase complex
O	0002070	biological_process	epithelial cell maturation
O	0005123	molecular_function	death receptor binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005739	cellular_component	mitochondrion
O	0005829	cellular_component	cytosol
O	0006915	biological_process	apoptotic process
O	0016567	biological_process	protein ubiquitination
O	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0046872	molecular_function	metal ion binding
O	0051438	biological_process	regulation of ubiquitin-protein transferase activity
O	0060442	biological_process	branching involved in prostate gland morphogenesis
O	0060743	biological_process	epithelial cell maturation involved in prostate gland development
O	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
O	1902041	biological_process	regulation of extrinsic apoptotic signaling pathway via death domain receptors
O	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
O	2000001	biological_process	regulation of DNA damage checkpoint
P	0000151	cellular_component	ubiquitin ligase complex
P	0002070	biological_process	epithelial cell maturation
P	0005123	molecular_function	death receptor binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005739	cellular_component	mitochondrion
P	0005829	cellular_component	cytosol
P	0006915	biological_process	apoptotic process
P	0016567	biological_process	protein ubiquitination
P	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0046872	molecular_function	metal ion binding
P	0051438	biological_process	regulation of ubiquitin-protein transferase activity
P	0060442	biological_process	branching involved in prostate gland morphogenesis
P	0060743	biological_process	epithelial cell maturation involved in prostate gland development
P	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
P	1902041	biological_process	regulation of extrinsic apoptotic signaling pathway via death domain receptors
P	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
P	2000001	biological_process	regulation of DNA damage checkpoint

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	116
Details	Repeat: {"description":"ANK 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	116
Details	Repeat: {"description":"ANK 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	116
Details	Repeat: {"description":"ANK 3"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	116
Details	Repeat: {"description":"ANK 4"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	116
Details	Repeat: {"description":"ANK 5"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	120
Details	Repeat: {"description":"ANK 6"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	132
Details	Repeat: {"description":"TPR"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	176
Details	Repeat: {"description":"ANK 7"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	111
Details	Repeat: {"description":"ANK 8"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9Z2G0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Site: {"description":"Cleavage; by a caspase-3-like protease","evidences":[{"source":"PubMed","id":"10542291","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"24896179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25621951","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"24896179","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)