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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9J78

Cryo-EM structure of CRL2-FEM1B (dimer 2)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0004842molecular_functionubiquitin-protein transferase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006511biological_processubiquitin-dependent protein catabolic process
A0010498biological_processproteasomal protein catabolic process
A0016567biological_processprotein ubiquitination
A0019005cellular_componentSCF ubiquitin ligase complex
A0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A0031461cellular_componentcullin-RING ubiquitin ligase complex
A0031462cellular_componentCul2-RING ubiquitin ligase complex
A0031625molecular_functionubiquitin protein ligase binding
A0031981cellular_componentnuclear lumen
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0072344biological_processrescue of stalled ribosome
A0097193biological_processintrinsic apoptotic signaling pathway
A0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
A0160072molecular_functionubiquitin ligase complex scaffold activity
A0160276biological_processnegative regulation of beige fat cell differentiation
A1990116biological_processribosome-associated ubiquitin-dependent protein catabolic process
A2000104biological_processnegative regulation of DNA-templated DNA replication
B0000082biological_processG1/S transition of mitotic cell cycle
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0004842molecular_functionubiquitin-protein transferase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006511biological_processubiquitin-dependent protein catabolic process
B0010498biological_processproteasomal protein catabolic process
B0016567biological_processprotein ubiquitination
B0019005cellular_componentSCF ubiquitin ligase complex
B0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B0031461cellular_componentcullin-RING ubiquitin ligase complex
B0031462cellular_componentCul2-RING ubiquitin ligase complex
B0031625molecular_functionubiquitin protein ligase binding
B0031981cellular_componentnuclear lumen
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0072344biological_processrescue of stalled ribosome
B0097193biological_processintrinsic apoptotic signaling pathway
B0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
B0160072molecular_functionubiquitin ligase complex scaffold activity
B0160276biological_processnegative regulation of beige fat cell differentiation
B1990116biological_processribosome-associated ubiquitin-dependent protein catabolic process
B2000104biological_processnegative regulation of DNA-templated DNA replication
C0006511biological_processubiquitin-dependent protein catabolic process
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000151cellular_componentubiquitin ligase complex
D0001222molecular_functiontranscription corepressor binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006351biological_processDNA-templated transcription
D0006367biological_processtranscription initiation at RNA polymerase II promoter
D0006368biological_processtranscription elongation by RNA polymerase II
D0016567biological_processprotein ubiquitination
D0030891cellular_componentVCB complex
D0031462cellular_componentCul2-RING ubiquitin ligase complex
D0031466cellular_componentCul5-RING ubiquitin ligase complex
D0031625molecular_functionubiquitin protein ligase binding
D0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0065003biological_processprotein-containing complex assembly
D0070449cellular_componentelongin complex
D0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
D0140958biological_processtarget-directed miRNA degradation
D1990116biological_processribosome-associated ubiquitin-dependent protein catabolic process
D2000104biological_processnegative regulation of DNA-templated DNA replication
E0008270molecular_functionzinc ion binding
F0000151cellular_componentubiquitin ligase complex
F0005123molecular_functiondeath receptor binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005829cellular_componentcytosol
F0006915biological_processapoptotic process
F0016567biological_processprotein ubiquitination
F0031462cellular_componentCul2-RING ubiquitin ligase complex
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0046872molecular_functionmetal ion binding
F0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
F1902041biological_processregulation of extrinsic apoptotic signaling pathway via death domain receptors
F1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
F2000001biological_processregulation of DNA damage checkpoint
G0006511biological_processubiquitin-dependent protein catabolic process
H0000122biological_processnegative regulation of transcription by RNA polymerase II
H0000151cellular_componentubiquitin ligase complex
H0001222molecular_functiontranscription corepressor binding
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006351biological_processDNA-templated transcription
H0006367biological_processtranscription initiation at RNA polymerase II promoter
H0006368biological_processtranscription elongation by RNA polymerase II
H0016567biological_processprotein ubiquitination
H0030891cellular_componentVCB complex
H0031462cellular_componentCul2-RING ubiquitin ligase complex
H0031466cellular_componentCul5-RING ubiquitin ligase complex
H0031625molecular_functionubiquitin protein ligase binding
H0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
H0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
H0065003biological_processprotein-containing complex assembly
H0070449cellular_componentelongin complex
H0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
H0140958biological_processtarget-directed miRNA degradation
H1990116biological_processribosome-associated ubiquitin-dependent protein catabolic process
H2000104biological_processnegative regulation of DNA-templated DNA replication
I0008270molecular_functionzinc ion binding
J0000151cellular_componentubiquitin ligase complex
J0005123molecular_functiondeath receptor binding
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005829cellular_componentcytosol
J0006915biological_processapoptotic process
J0016567biological_processprotein ubiquitination
J0031462cellular_componentCul2-RING ubiquitin ligase complex
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0046872molecular_functionmetal ion binding
J0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
J1902041biological_processregulation of extrinsic apoptotic signaling pathway via death domain receptors
J1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
J2000001biological_processregulation of DNA damage checkpoint
Functional Information from PROSITE/UniProt
site_idPS01256
Number of Residues28
DetailsCULLIN_1 Cullin family signature. IKkcIevLIDKqYIeRsqasadeYsYvA
ChainResidueDetails
BILE718-ALA745
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues65
DetailsDomain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues120
DetailsDomain: {"description":"Cullin neddylation","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)","evidences":[{"source":"PubMed","id":"10092517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10597293","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues58
DetailsRepeat: {"description":"ANK 1"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues58
DetailsRepeat: {"description":"ANK 2"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues58
DetailsRepeat: {"description":"ANK 3"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues58
DetailsRepeat: {"description":"ANK 4"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues58
DetailsRepeat: {"description":"ANK 5"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues60
DetailsRepeat: {"description":"ANK 6"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues66
DetailsRepeat: {"description":"TPR"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues88
DetailsRepeat: {"description":"ANK 7"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues74
DetailsRepeat: {"description":"ANK 8"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q9Z2G0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsSite: {"description":"Cleavage; by a caspase-3-like protease","evidences":[{"source":"PubMed","id":"10542291","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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