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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9J5K

Pathogen effector forms a phosphatase holoenzyme complex with host core enzyme to promote disease

Functional Information from GO Data
ChainGOidnamespacecontents
A0000159cellular_componentprotein phosphatase type 2A complex
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005777cellular_componentperoxisome
A0005829cellular_componentcytosol
A0019888molecular_functionprotein phosphatase regulator activity
A0042325biological_processregulation of phosphorylation
C0000159cellular_componentprotein phosphatase type 2A complex
C0000278biological_processmitotic cell cycle
C0000775cellular_componentchromosome, centromeric region
C0000785cellular_componentchromatin
C0000922cellular_componentspindle pole
C0004721molecular_functionphosphoprotein phosphatase activity
C0004722molecular_functionprotein serine/threonine phosphatase activity
C0004725molecular_functionprotein tyrosine phosphatase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005694cellular_componentchromosome
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006357biological_processregulation of transcription by RNA polymerase II
C0006470biological_processprotein dephosphorylation
C0008287cellular_componentprotein serine/threonine phosphatase complex
C0010288biological_processresponse to lead ion
C0010719biological_processnegative regulation of epithelial to mesenchymal transition
C0015630cellular_componentmicrotubule cytoskeleton
C0016020cellular_componentmembrane
C0016180biological_processsnRNA processing
C0031113biological_processregulation of microtubule polymerization
C0032039cellular_componentintegrator complex
C0034243biological_processregulation of transcription elongation by RNA polymerase II
C0035330biological_processregulation of hippo signaling
C0035331biological_processnegative regulation of hippo signaling
C0035556biological_processintracellular signal transduction
C0040008biological_processregulation of growth
C0043029biological_processT cell homeostasis
C0045121cellular_componentmembrane raft
C0045202cellular_componentsynapse
C0045595biological_processregulation of cell differentiation
C0046982molecular_functionprotein heterodimerization activity
C0048156molecular_functiontau protein binding
C0050811molecular_functionGABA receptor binding
C0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0070062cellular_componentextracellular exosome
C0090090biological_processnegative regulation of canonical Wnt signaling pathway
C0090443cellular_componentFAR/SIN/STRIPAK complex
C0097706biological_processvascular endothelial cell response to oscillatory fluid shear stress
C0160232cellular_componentINTAC complex
C0160240biological_processRNA polymerase II transcription initiation surveillance
C0180006molecular_functionRNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
C0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
C0180008molecular_functionRNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
C1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
C1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
C2000045biological_processregulation of G1/S transition of mitotic cell cycle
D0000159cellular_componentprotein phosphatase type 2A complex
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005777cellular_componentperoxisome
D0005829cellular_componentcytosol
D0019888molecular_functionprotein phosphatase regulator activity
D0042325biological_processregulation of phosphorylation
F0000159cellular_componentprotein phosphatase type 2A complex
F0000278biological_processmitotic cell cycle
F0000775cellular_componentchromosome, centromeric region
F0000785cellular_componentchromatin
F0000922cellular_componentspindle pole
F0004721molecular_functionphosphoprotein phosphatase activity
F0004722molecular_functionprotein serine/threonine phosphatase activity
F0004725molecular_functionprotein tyrosine phosphatase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005694cellular_componentchromosome
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006357biological_processregulation of transcription by RNA polymerase II
F0006470biological_processprotein dephosphorylation
F0008287cellular_componentprotein serine/threonine phosphatase complex
F0010288biological_processresponse to lead ion
F0010719biological_processnegative regulation of epithelial to mesenchymal transition
F0015630cellular_componentmicrotubule cytoskeleton
F0016020cellular_componentmembrane
F0016180biological_processsnRNA processing
F0031113biological_processregulation of microtubule polymerization
F0032039cellular_componentintegrator complex
F0034243biological_processregulation of transcription elongation by RNA polymerase II
F0035330biological_processregulation of hippo signaling
F0035331biological_processnegative regulation of hippo signaling
F0035556biological_processintracellular signal transduction
F0040008biological_processregulation of growth
F0043029biological_processT cell homeostasis
F0045121cellular_componentmembrane raft
F0045202cellular_componentsynapse
F0045595biological_processregulation of cell differentiation
F0046982molecular_functionprotein heterodimerization activity
F0048156molecular_functiontau protein binding
F0050811molecular_functionGABA receptor binding
F0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F0070062cellular_componentextracellular exosome
F0090090biological_processnegative regulation of canonical Wnt signaling pathway
F0090443cellular_componentFAR/SIN/STRIPAK complex
F0097706biological_processvascular endothelial cell response to oscillatory fluid shear stress
F0160232cellular_componentINTAC complex
F0160240biological_processRNA polymerase II transcription initiation surveillance
F0180006molecular_functionRNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
F0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
F0180008molecular_functionRNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
F1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
F1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
F2000045biological_processregulation of G1/S transition of mitotic cell cycle
Functional Information from PROSITE/UniProt
site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
CLEU114-GLU119
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17055435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33633399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues180
DetailsRepeat: {"description":"LWY3","evidences":[{"source":"PubMed","id":"30926664","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues184
DetailsRepeat: {"description":"LWY5","evidences":[{"source":"PubMed","id":"30926664","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues180
DetailsRepeat: {"description":"LWY6","evidences":[{"source":"PubMed","id":"30926664","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues172
DetailsRepeat: {"description":"LWY7","evidences":[{"source":"PubMed","id":"30926664","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues72
DetailsRepeat: {"description":"HEAT 2"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues76
DetailsRepeat: {"description":"HEAT 3"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues76
DetailsRepeat: {"description":"HEAT 4"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues76
DetailsRepeat: {"description":"HEAT 5"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues76
DetailsRepeat: {"description":"HEAT 7"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues74
DetailsRepeat: {"description":"HEAT 8"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues76
DetailsRepeat: {"description":"HEAT 9"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues74
DetailsRepeat: {"description":"HEAT 10"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues74
DetailsRepeat: {"description":"HEAT 11"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues76
DetailsRepeat: {"description":"HEAT 12"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues76
DetailsRepeat: {"description":"HEAT 13"}
ChainResidueDetails

254587

PDB entries from 2026-06-03

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