9J4F

Cryo-EM structure of P25alpha full-length A119V fibril

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0001578	biological_process	microtubule bundle formation
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005815	cellular_component	microtubule organizing center
A	0005819	cellular_component	spindle
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0008017	molecular_function	microtubule binding
A	0014003	biological_process	oligodendrocyte development
A	0015631	molecular_function	tubulin binding
A	0016787	molecular_function	hydrolase activity
A	0030953	biological_process	astral microtubule organization
A	0031334	biological_process	positive regulation of protein-containing complex assembly
A	0031643	biological_process	positive regulation of myelination
A	0032273	biological_process	positive regulation of protein polymerization
A	0032288	biological_process	myelin assembly
A	0042803	molecular_function	protein homodimerization activity
A	0046785	biological_process	microtubule polymerization
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0048709	biological_process	oligodendrocyte differentiation
A	0051301	biological_process	cell division
A	0051418	biological_process	microtubule nucleation by microtubule organizing center
A	0070507	biological_process	regulation of microtubule cytoskeleton organization
A	0072686	cellular_component	mitotic spindle
A	0097427	cellular_component	microtubule bundle
A	0150051	cellular_component	postsynaptic Golgi apparatus
A	1904428	biological_process	negative regulation of tubulin deacetylation
B	0000287	molecular_function	magnesium ion binding
B	0001578	biological_process	microtubule bundle formation
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005815	cellular_component	microtubule organizing center
B	0005819	cellular_component	spindle
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0008017	molecular_function	microtubule binding
B	0014003	biological_process	oligodendrocyte development
B	0015631	molecular_function	tubulin binding
B	0016787	molecular_function	hydrolase activity
B	0030953	biological_process	astral microtubule organization
B	0031334	biological_process	positive regulation of protein-containing complex assembly
B	0031643	biological_process	positive regulation of myelination
B	0032273	biological_process	positive regulation of protein polymerization
B	0032288	biological_process	myelin assembly
B	0042803	molecular_function	protein homodimerization activity
B	0046785	biological_process	microtubule polymerization
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0048709	biological_process	oligodendrocyte differentiation
B	0051301	biological_process	cell division
B	0051418	biological_process	microtubule nucleation by microtubule organizing center
B	0070507	biological_process	regulation of microtubule cytoskeleton organization
B	0072686	cellular_component	mitotic spindle
B	0097427	cellular_component	microtubule bundle
B	0150051	cellular_component	postsynaptic Golgi apparatus
B	1904428	biological_process	negative regulation of tubulin deacetylation
C	0000287	molecular_function	magnesium ion binding
C	0001578	biological_process	microtubule bundle formation
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005815	cellular_component	microtubule organizing center
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0008017	molecular_function	microtubule binding
C	0014003	biological_process	oligodendrocyte development
C	0015631	molecular_function	tubulin binding
C	0016787	molecular_function	hydrolase activity
C	0030953	biological_process	astral microtubule organization
C	0031334	biological_process	positive regulation of protein-containing complex assembly
C	0031643	biological_process	positive regulation of myelination
C	0032273	biological_process	positive regulation of protein polymerization
C	0032288	biological_process	myelin assembly
C	0042803	molecular_function	protein homodimerization activity
C	0046785	biological_process	microtubule polymerization
C	0046872	molecular_function	metal ion binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0048709	biological_process	oligodendrocyte differentiation
C	0051301	biological_process	cell division
C	0051418	biological_process	microtubule nucleation by microtubule organizing center
C	0070507	biological_process	regulation of microtubule cytoskeleton organization
C	0072686	cellular_component	mitotic spindle
C	0097427	cellular_component	microtubule bundle
C	0150051	cellular_component	postsynaptic Golgi apparatus
C	1904428	biological_process	negative regulation of tubulin deacetylation
D	0000287	molecular_function	magnesium ion binding
D	0001578	biological_process	microtubule bundle formation
D	0003924	molecular_function	GTPase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005815	cellular_component	microtubule organizing center
D	0005819	cellular_component	spindle
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0008017	molecular_function	microtubule binding
D	0014003	biological_process	oligodendrocyte development
D	0015631	molecular_function	tubulin binding
D	0016787	molecular_function	hydrolase activity
D	0030953	biological_process	astral microtubule organization
D	0031334	biological_process	positive regulation of protein-containing complex assembly
D	0031643	biological_process	positive regulation of myelination
D	0032273	biological_process	positive regulation of protein polymerization
D	0032288	biological_process	myelin assembly
D	0042803	molecular_function	protein homodimerization activity
D	0046785	biological_process	microtubule polymerization
D	0046872	molecular_function	metal ion binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0048709	biological_process	oligodendrocyte differentiation
D	0051301	biological_process	cell division
D	0051418	biological_process	microtubule nucleation by microtubule organizing center
D	0070507	biological_process	regulation of microtubule cytoskeleton organization
D	0072686	cellular_component	mitotic spindle
D	0097427	cellular_component	microtubule bundle
D	0150051	cellular_component	postsynaptic Golgi apparatus
D	1904428	biological_process	negative regulation of tubulin deacetylation
E	0000287	molecular_function	magnesium ion binding
E	0001578	biological_process	microtubule bundle formation
E	0003924	molecular_function	GTPase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005815	cellular_component	microtubule organizing center
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0008017	molecular_function	microtubule binding
E	0014003	biological_process	oligodendrocyte development
E	0015631	molecular_function	tubulin binding
E	0016787	molecular_function	hydrolase activity
E	0030953	biological_process	astral microtubule organization
E	0031334	biological_process	positive regulation of protein-containing complex assembly
E	0031643	biological_process	positive regulation of myelination
E	0032273	biological_process	positive regulation of protein polymerization
E	0032288	biological_process	myelin assembly
E	0042803	molecular_function	protein homodimerization activity
E	0046785	biological_process	microtubule polymerization
E	0046872	molecular_function	metal ion binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0048709	biological_process	oligodendrocyte differentiation
E	0051301	biological_process	cell division
E	0051418	biological_process	microtubule nucleation by microtubule organizing center
E	0070507	biological_process	regulation of microtubule cytoskeleton organization
E	0072686	cellular_component	mitotic spindle
E	0097427	cellular_component	microtubule bundle
E	0150051	cellular_component	postsynaptic Golgi apparatus
E	1904428	biological_process	negative regulation of tubulin deacetylation
F	0000287	molecular_function	magnesium ion binding
F	0001578	biological_process	microtubule bundle formation
F	0003924	molecular_function	GTPase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005815	cellular_component	microtubule organizing center
F	0005819	cellular_component	spindle
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0008017	molecular_function	microtubule binding
F	0014003	biological_process	oligodendrocyte development
F	0015631	molecular_function	tubulin binding
F	0016787	molecular_function	hydrolase activity
F	0030953	biological_process	astral microtubule organization
F	0031334	biological_process	positive regulation of protein-containing complex assembly
F	0031643	biological_process	positive regulation of myelination
F	0032273	biological_process	positive regulation of protein polymerization
F	0032288	biological_process	myelin assembly
F	0042803	molecular_function	protein homodimerization activity
F	0046785	biological_process	microtubule polymerization
F	0046872	molecular_function	metal ion binding
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0048709	biological_process	oligodendrocyte differentiation
F	0051301	biological_process	cell division
F	0051418	biological_process	microtubule nucleation by microtubule organizing center
F	0070507	biological_process	regulation of microtubule cytoskeleton organization
F	0072686	cellular_component	mitotic spindle
F	0097427	cellular_component	microtubule bundle
F	0150051	cellular_component	postsynaptic Golgi apparatus
F	1904428	biological_process	negative regulation of tubulin deacetylation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21995432","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine; by PKA; in vitro","evidences":[{"source":"PubMed","id":"17693641","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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