Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9J3P

Human Pigment Epithelium-Derived Factor with Zinc Ions Crystallized in P2(1)2(1)2(1) Space Group

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001822	biological_process	kidney development
A	0004867	molecular_function	serine-type endopeptidase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005604	cellular_component	basement membrane
A	0005615	cellular_component	extracellular space
A	0007614	biological_process	short-term memory
A	0010447	biological_process	response to acidic pH
A	0010596	biological_process	negative regulation of endothelial cell migration
A	0010629	biological_process	negative regulation of gene expression
A	0010976	biological_process	positive regulation of neuron projection development
A	0016525	biological_process	negative regulation of angiogenesis
A	0030424	cellular_component	axon
A	0031012	cellular_component	extracellular matrix
A	0042470	cellular_component	melanosome
A	0042698	biological_process	ovulation cycle
A	0043025	cellular_component	neuronal cell body
A	0043203	cellular_component	axon hillock
A	0046685	biological_process	response to arsenic-containing substance
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050769	biological_process	positive regulation of neurogenesis
A	0060041	biological_process	retina development in camera-type eye
A	0070062	cellular_component	extracellular exosome
A	0071279	biological_process	cellular response to cobalt ion
A	0071300	biological_process	cellular response to retinoic acid
A	0071333	biological_process	cellular response to glucose stimulus
A	0071549	biological_process	cellular response to dexamethasone stimulus
A	1901652	biological_process	response to peptide
B	0001822	biological_process	kidney development
B	0004867	molecular_function	serine-type endopeptidase inhibitor activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005604	cellular_component	basement membrane
B	0005615	cellular_component	extracellular space
B	0007614	biological_process	short-term memory
B	0010447	biological_process	response to acidic pH
B	0010596	biological_process	negative regulation of endothelial cell migration
B	0010629	biological_process	negative regulation of gene expression
B	0010976	biological_process	positive regulation of neuron projection development
B	0016525	biological_process	negative regulation of angiogenesis
B	0030424	cellular_component	axon
B	0031012	cellular_component	extracellular matrix
B	0042470	cellular_component	melanosome
B	0042698	biological_process	ovulation cycle
B	0043025	cellular_component	neuronal cell body
B	0043203	cellular_component	axon hillock
B	0046685	biological_process	response to arsenic-containing substance
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0050769	biological_process	positive regulation of neurogenesis
B	0060041	biological_process	retina development in camera-type eye
B	0070062	cellular_component	extracellular exosome
B	0071279	biological_process	cellular response to cobalt ion
B	0071300	biological_process	cellular response to retinoic acid
B	0071333	biological_process	cellular response to glucose stimulus
B	0071549	biological_process	cellular response to dexamethasone stimulus
B	1901652	biological_process	response to peptide
C	0001822	biological_process	kidney development
C	0004867	molecular_function	serine-type endopeptidase inhibitor activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005604	cellular_component	basement membrane
C	0005615	cellular_component	extracellular space
C	0007614	biological_process	short-term memory
C	0010447	biological_process	response to acidic pH
C	0010596	biological_process	negative regulation of endothelial cell migration
C	0010629	biological_process	negative regulation of gene expression
C	0010976	biological_process	positive regulation of neuron projection development
C	0016525	biological_process	negative regulation of angiogenesis
C	0030424	cellular_component	axon
C	0031012	cellular_component	extracellular matrix
C	0042470	cellular_component	melanosome
C	0042698	biological_process	ovulation cycle
C	0043025	cellular_component	neuronal cell body
C	0043203	cellular_component	axon hillock
C	0046685	biological_process	response to arsenic-containing substance
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0050769	biological_process	positive regulation of neurogenesis
C	0060041	biological_process	retina development in camera-type eye
C	0070062	cellular_component	extracellular exosome
C	0071279	biological_process	cellular response to cobalt ion
C	0071300	biological_process	cellular response to retinoic acid
C	0071333	biological_process	cellular response to glucose stimulus
C	0071549	biological_process	cellular response to dexamethasone stimulus
C	1901652	biological_process	response to peptide
D	0001822	biological_process	kidney development
D	0004867	molecular_function	serine-type endopeptidase inhibitor activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005604	cellular_component	basement membrane
D	0005615	cellular_component	extracellular space
D	0007614	biological_process	short-term memory
D	0010447	biological_process	response to acidic pH
D	0010596	biological_process	negative regulation of endothelial cell migration
D	0010629	biological_process	negative regulation of gene expression
D	0010976	biological_process	positive regulation of neuron projection development
D	0016525	biological_process	negative regulation of angiogenesis
D	0030424	cellular_component	axon
D	0031012	cellular_component	extracellular matrix
D	0042470	cellular_component	melanosome
D	0042698	biological_process	ovulation cycle
D	0043025	cellular_component	neuronal cell body
D	0043203	cellular_component	axon hillock
D	0046685	biological_process	response to arsenic-containing substance
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0050769	biological_process	positive regulation of neurogenesis
D	0060041	biological_process	retina development in camera-type eye
D	0070062	cellular_component	extracellular exosome
D	0071279	biological_process	cellular response to cobalt ion
D	0071300	biological_process	cellular response to retinoic acid
D	0071333	biological_process	cellular response to glucose stimulus
D	0071549	biological_process	cellular response to dexamethasone stimulus
D	1901652	biological_process	response to peptide
E	0001822	biological_process	kidney development
E	0004867	molecular_function	serine-type endopeptidase inhibitor activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005604	cellular_component	basement membrane
E	0005615	cellular_component	extracellular space
E	0007614	biological_process	short-term memory
E	0010447	biological_process	response to acidic pH
E	0010596	biological_process	negative regulation of endothelial cell migration
E	0010629	biological_process	negative regulation of gene expression
E	0010976	biological_process	positive regulation of neuron projection development
E	0016525	biological_process	negative regulation of angiogenesis
E	0030424	cellular_component	axon
E	0031012	cellular_component	extracellular matrix
E	0042470	cellular_component	melanosome
E	0042698	biological_process	ovulation cycle
E	0043025	cellular_component	neuronal cell body
E	0043203	cellular_component	axon hillock
E	0046685	biological_process	response to arsenic-containing substance
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0050769	biological_process	positive regulation of neurogenesis
E	0060041	biological_process	retina development in camera-type eye
E	0070062	cellular_component	extracellular exosome
E	0071279	biological_process	cellular response to cobalt ion
E	0071300	biological_process	cellular response to retinoic acid
E	0071333	biological_process	cellular response to glucose stimulus
E	0071549	biological_process	cellular response to dexamethasone stimulus
E	1901652	biological_process	response to peptide

Functional Information from PROSITE/UniProt

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. YHLNQPFIFvL

Chain	Residue	Details
A	TYR388-LEU398

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Region: {"description":"O-glycosylated at one site"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by CK2","evidences":[{"source":"PubMed","id":"15374885","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"15374885","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"11562499","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)