9IXU

Overall reconstruction of the Bax line

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001783	biological_process	B cell apoptotic process
A	0001836	biological_process	release of cytochrome c from mitochondria
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005757	cellular_component	mitochondrial permeability transition pore complex
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0006915	biological_process	apoptotic process
A	0008053	biological_process	mitochondrial fusion
A	0008289	molecular_function	lipid binding
A	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0008637	biological_process	apoptotic mitochondrial changes
A	0009636	biological_process	response to toxic substance
A	0010248	biological_process	establishment or maintenance of transmembrane electrochemical gradient
A	0010917	biological_process	negative regulation of mitochondrial membrane potential
A	0015267	molecular_function	channel activity
A	0016020	cellular_component	membrane
A	0030544	molecular_function	Hsp70 protein binding
A	0031334	biological_process	positive regulation of protein-containing complex assembly
A	0031966	cellular_component	mitochondrial membrane
A	0032091	biological_process	negative regulation of protein binding
A	0032469	biological_process	endoplasmic reticulum calcium ion homeostasis
A	0032976	biological_process	release of matrix enzymes from mitochondria
A	0033554	biological_process	cellular response to stress
A	0034620	biological_process	cellular response to unfolded protein
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0042981	biological_process	regulation of apoptotic process
A	0043065	biological_process	positive regulation of apoptotic process
A	0043525	biological_process	positive regulation of neuron apoptotic process
A	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
A	0046930	cellular_component	pore complex
A	0046982	molecular_function	protein heterodimerization activity
A	0051087	molecular_function	protein-folding chaperone binding
A	0051434	molecular_function	BH3 domain binding
A	0051881	biological_process	regulation of mitochondrial membrane potential
A	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
A	0070062	cellular_component	extracellular exosome
A	0071944	cellular_component	cell periphery
A	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
A	0097136	cellular_component	Bcl-2 family protein complex
A	0097144	cellular_component	BAX complex
A	0097145	cellular_component	BAK complex
A	0097190	biological_process	apoptotic signaling pathway
A	0097191	biological_process	extrinsic apoptotic signaling pathway
A	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
A	0097193	biological_process	intrinsic apoptotic signaling pathway
A	0097194	biological_process	execution phase of apoptosis
A	0097435	biological_process	supramolecular fiber organization
A	0098586	biological_process	cellular response to virus
A	1902512	biological_process	positive regulation of apoptotic DNA fragmentation
A	1902531	biological_process	regulation of intracellular signal transduction
A	1903896	biological_process	positive regulation of IRE1-mediated unfolded protein response
A	1990117	biological_process	B cell receptor apoptotic signaling pathway
A	2001233	biological_process	regulation of apoptotic signaling pathway
A	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
B	0001783	biological_process	B cell apoptotic process
B	0001836	biological_process	release of cytochrome c from mitochondria
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005757	cellular_component	mitochondrial permeability transition pore complex
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0006915	biological_process	apoptotic process
B	0008053	biological_process	mitochondrial fusion
B	0008289	molecular_function	lipid binding
B	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
B	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
B	0008637	biological_process	apoptotic mitochondrial changes
B	0009636	biological_process	response to toxic substance
B	0010248	biological_process	establishment or maintenance of transmembrane electrochemical gradient
B	0010917	biological_process	negative regulation of mitochondrial membrane potential
B	0015267	molecular_function	channel activity
B	0016020	cellular_component	membrane
B	0030544	molecular_function	Hsp70 protein binding
B	0031334	biological_process	positive regulation of protein-containing complex assembly
B	0031966	cellular_component	mitochondrial membrane
B	0032091	biological_process	negative regulation of protein binding
B	0032469	biological_process	endoplasmic reticulum calcium ion homeostasis
B	0032976	biological_process	release of matrix enzymes from mitochondria
B	0033554	biological_process	cellular response to stress
B	0034620	biological_process	cellular response to unfolded protein
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042981	biological_process	regulation of apoptotic process
B	0043065	biological_process	positive regulation of apoptotic process
B	0043525	biological_process	positive regulation of neuron apoptotic process
B	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
B	0046930	cellular_component	pore complex
B	0046982	molecular_function	protein heterodimerization activity
B	0051087	molecular_function	protein-folding chaperone binding
B	0051434	molecular_function	BH3 domain binding
B	0051881	biological_process	regulation of mitochondrial membrane potential
B	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
B	0070062	cellular_component	extracellular exosome
B	0071944	cellular_component	cell periphery
B	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
B	0097136	cellular_component	Bcl-2 family protein complex
B	0097144	cellular_component	BAX complex
B	0097145	cellular_component	BAK complex
B	0097190	biological_process	apoptotic signaling pathway
B	0097191	biological_process	extrinsic apoptotic signaling pathway
B	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
B	0097193	biological_process	intrinsic apoptotic signaling pathway
B	0097194	biological_process	execution phase of apoptosis
B	0097435	biological_process	supramolecular fiber organization
B	0098586	biological_process	cellular response to virus
B	1902512	biological_process	positive regulation of apoptotic DNA fragmentation
B	1902531	biological_process	regulation of intracellular signal transduction
B	1903896	biological_process	positive regulation of IRE1-mediated unfolded protein response
B	1990117	biological_process	B cell receptor apoptotic signaling pathway
B	2001233	biological_process	regulation of apoptotic signaling pathway
B	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
C	0001783	biological_process	B cell apoptotic process
C	0001836	biological_process	release of cytochrome c from mitochondria
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005757	cellular_component	mitochondrial permeability transition pore complex
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0006915	biological_process	apoptotic process
C	0008053	biological_process	mitochondrial fusion
C	0008289	molecular_function	lipid binding
C	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
C	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
C	0008637	biological_process	apoptotic mitochondrial changes
C	0009636	biological_process	response to toxic substance
C	0010248	biological_process	establishment or maintenance of transmembrane electrochemical gradient
C	0010917	biological_process	negative regulation of mitochondrial membrane potential
C	0015267	molecular_function	channel activity
C	0016020	cellular_component	membrane
C	0030544	molecular_function	Hsp70 protein binding
C	0031334	biological_process	positive regulation of protein-containing complex assembly
C	0031966	cellular_component	mitochondrial membrane
C	0032091	biological_process	negative regulation of protein binding
C	0032469	biological_process	endoplasmic reticulum calcium ion homeostasis
C	0032976	biological_process	release of matrix enzymes from mitochondria
C	0033554	biological_process	cellular response to stress
C	0034620	biological_process	cellular response to unfolded protein
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0042981	biological_process	regulation of apoptotic process
C	0043065	biological_process	positive regulation of apoptotic process
C	0043525	biological_process	positive regulation of neuron apoptotic process
C	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
C	0046930	cellular_component	pore complex
C	0046982	molecular_function	protein heterodimerization activity
C	0051087	molecular_function	protein-folding chaperone binding
C	0051434	molecular_function	BH3 domain binding
C	0051881	biological_process	regulation of mitochondrial membrane potential
C	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
C	0070062	cellular_component	extracellular exosome
C	0071944	cellular_component	cell periphery
C	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
C	0097136	cellular_component	Bcl-2 family protein complex
C	0097144	cellular_component	BAX complex
C	0097145	cellular_component	BAK complex
C	0097190	biological_process	apoptotic signaling pathway
C	0097191	biological_process	extrinsic apoptotic signaling pathway
C	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0097194	biological_process	execution phase of apoptosis
C	0097435	biological_process	supramolecular fiber organization
C	0098586	biological_process	cellular response to virus
C	1902512	biological_process	positive regulation of apoptotic DNA fragmentation
C	1902531	biological_process	regulation of intracellular signal transduction
C	1903896	biological_process	positive regulation of IRE1-mediated unfolded protein response
C	1990117	biological_process	B cell receptor apoptotic signaling pathway
C	2001233	biological_process	regulation of apoptotic signaling pathway
C	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
D	0001783	biological_process	B cell apoptotic process
D	0001836	biological_process	release of cytochrome c from mitochondria
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005635	cellular_component	nuclear envelope
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005741	cellular_component	mitochondrial outer membrane
D	0005757	cellular_component	mitochondrial permeability transition pore complex
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005829	cellular_component	cytosol
D	0006915	biological_process	apoptotic process
D	0008053	biological_process	mitochondrial fusion
D	0008289	molecular_function	lipid binding
D	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
D	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
D	0008637	biological_process	apoptotic mitochondrial changes
D	0009636	biological_process	response to toxic substance
D	0010248	biological_process	establishment or maintenance of transmembrane electrochemical gradient
D	0010917	biological_process	negative regulation of mitochondrial membrane potential
D	0015267	molecular_function	channel activity
D	0016020	cellular_component	membrane
D	0030544	molecular_function	Hsp70 protein binding
D	0031334	biological_process	positive regulation of protein-containing complex assembly
D	0031966	cellular_component	mitochondrial membrane
D	0032091	biological_process	negative regulation of protein binding
D	0032469	biological_process	endoplasmic reticulum calcium ion homeostasis
D	0032976	biological_process	release of matrix enzymes from mitochondria
D	0033554	biological_process	cellular response to stress
D	0034620	biological_process	cellular response to unfolded protein
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042981	biological_process	regulation of apoptotic process
D	0043065	biological_process	positive regulation of apoptotic process
D	0043525	biological_process	positive regulation of neuron apoptotic process
D	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
D	0046930	cellular_component	pore complex
D	0046982	molecular_function	protein heterodimerization activity
D	0051087	molecular_function	protein-folding chaperone binding
D	0051434	molecular_function	BH3 domain binding
D	0051881	biological_process	regulation of mitochondrial membrane potential
D	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
D	0070062	cellular_component	extracellular exosome
D	0071944	cellular_component	cell periphery
D	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
D	0097136	cellular_component	Bcl-2 family protein complex
D	0097144	cellular_component	BAX complex
D	0097145	cellular_component	BAK complex
D	0097190	biological_process	apoptotic signaling pathway
D	0097191	biological_process	extrinsic apoptotic signaling pathway
D	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
D	0097193	biological_process	intrinsic apoptotic signaling pathway
D	0097194	biological_process	execution phase of apoptosis
D	0097435	biological_process	supramolecular fiber organization
D	0098586	biological_process	cellular response to virus
D	1902512	biological_process	positive regulation of apoptotic DNA fragmentation
D	1902531	biological_process	regulation of intracellular signal transduction
D	1903896	biological_process	positive regulation of IRE1-mediated unfolded protein response
D	1990117	biological_process	B cell receptor apoptotic signaling pathway
D	2001233	biological_process	regulation of apoptotic signaling pathway
D	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
E	0001783	biological_process	B cell apoptotic process
E	0001836	biological_process	release of cytochrome c from mitochondria
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005635	cellular_component	nuclear envelope
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005741	cellular_component	mitochondrial outer membrane
E	0005757	cellular_component	mitochondrial permeability transition pore complex
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005829	cellular_component	cytosol
E	0006915	biological_process	apoptotic process
E	0008053	biological_process	mitochondrial fusion
E	0008289	molecular_function	lipid binding
E	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
E	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
E	0008637	biological_process	apoptotic mitochondrial changes
E	0009636	biological_process	response to toxic substance
E	0010248	biological_process	establishment or maintenance of transmembrane electrochemical gradient
E	0010917	biological_process	negative regulation of mitochondrial membrane potential
E	0015267	molecular_function	channel activity
E	0016020	cellular_component	membrane
E	0030544	molecular_function	Hsp70 protein binding
E	0031334	biological_process	positive regulation of protein-containing complex assembly
E	0031966	cellular_component	mitochondrial membrane
E	0032091	biological_process	negative regulation of protein binding
E	0032469	biological_process	endoplasmic reticulum calcium ion homeostasis
E	0032976	biological_process	release of matrix enzymes from mitochondria
E	0033554	biological_process	cellular response to stress
E	0034620	biological_process	cellular response to unfolded protein
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0042981	biological_process	regulation of apoptotic process
E	0043065	biological_process	positive regulation of apoptotic process
E	0043525	biological_process	positive regulation of neuron apoptotic process
E	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
E	0046930	cellular_component	pore complex
E	0046982	molecular_function	protein heterodimerization activity
E	0051087	molecular_function	protein-folding chaperone binding
E	0051434	molecular_function	BH3 domain binding
E	0051881	biological_process	regulation of mitochondrial membrane potential
E	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
E	0070062	cellular_component	extracellular exosome
E	0071944	cellular_component	cell periphery
E	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
E	0097136	cellular_component	Bcl-2 family protein complex
E	0097144	cellular_component	BAX complex
E	0097145	cellular_component	BAK complex
E	0097190	biological_process	apoptotic signaling pathway
E	0097191	biological_process	extrinsic apoptotic signaling pathway
E	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
E	0097193	biological_process	intrinsic apoptotic signaling pathway
E	0097194	biological_process	execution phase of apoptosis
E	0097435	biological_process	supramolecular fiber organization
E	0098586	biological_process	cellular response to virus
E	1902512	biological_process	positive regulation of apoptotic DNA fragmentation
E	1902531	biological_process	regulation of intracellular signal transduction
E	1903896	biological_process	positive regulation of IRE1-mediated unfolded protein response
E	1990117	biological_process	B cell receptor apoptotic signaling pathway
E	2001233	biological_process	regulation of apoptotic signaling pathway
E	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
F	0001783	biological_process	B cell apoptotic process
F	0001836	biological_process	release of cytochrome c from mitochondria
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005635	cellular_component	nuclear envelope
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005741	cellular_component	mitochondrial outer membrane
F	0005757	cellular_component	mitochondrial permeability transition pore complex
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005829	cellular_component	cytosol
F	0006915	biological_process	apoptotic process
F	0008053	biological_process	mitochondrial fusion
F	0008289	molecular_function	lipid binding
F	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
F	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
F	0008637	biological_process	apoptotic mitochondrial changes
F	0009636	biological_process	response to toxic substance
F	0010248	biological_process	establishment or maintenance of transmembrane electrochemical gradient
F	0010917	biological_process	negative regulation of mitochondrial membrane potential
F	0015267	molecular_function	channel activity
F	0016020	cellular_component	membrane
F	0030544	molecular_function	Hsp70 protein binding
F	0031334	biological_process	positive regulation of protein-containing complex assembly
F	0031966	cellular_component	mitochondrial membrane
F	0032091	biological_process	negative regulation of protein binding
F	0032469	biological_process	endoplasmic reticulum calcium ion homeostasis
F	0032976	biological_process	release of matrix enzymes from mitochondria
F	0033554	biological_process	cellular response to stress
F	0034620	biological_process	cellular response to unfolded protein
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0042981	biological_process	regulation of apoptotic process
F	0043065	biological_process	positive regulation of apoptotic process
F	0043525	biological_process	positive regulation of neuron apoptotic process
F	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
F	0046930	cellular_component	pore complex
F	0046982	molecular_function	protein heterodimerization activity
F	0051087	molecular_function	protein-folding chaperone binding
F	0051434	molecular_function	BH3 domain binding
F	0051881	biological_process	regulation of mitochondrial membrane potential
F	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
F	0070062	cellular_component	extracellular exosome
F	0071944	cellular_component	cell periphery
F	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
F	0097136	cellular_component	Bcl-2 family protein complex
F	0097144	cellular_component	BAX complex
F	0097145	cellular_component	BAK complex
F	0097190	biological_process	apoptotic signaling pathway
F	0097191	biological_process	extrinsic apoptotic signaling pathway
F	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
F	0097193	biological_process	intrinsic apoptotic signaling pathway
F	0097194	biological_process	execution phase of apoptosis
F	0097435	biological_process	supramolecular fiber organization
F	0098586	biological_process	cellular response to virus
F	1902512	biological_process	positive regulation of apoptotic DNA fragmentation
F	1902531	biological_process	regulation of intracellular signal transduction
F	1903896	biological_process	positive regulation of IRE1-mediated unfolded protein response
F	1990117	biological_process	B cell receptor apoptotic signaling pathway
F	2001233	biological_process	regulation of apoptotic signaling pathway
F	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
G	0001783	biological_process	B cell apoptotic process
G	0001836	biological_process	release of cytochrome c from mitochondria
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005635	cellular_component	nuclear envelope
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005741	cellular_component	mitochondrial outer membrane
G	0005757	cellular_component	mitochondrial permeability transition pore complex
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005829	cellular_component	cytosol
G	0006915	biological_process	apoptotic process
G	0008053	biological_process	mitochondrial fusion
G	0008289	molecular_function	lipid binding
G	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
G	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
G	0008637	biological_process	apoptotic mitochondrial changes
G	0009636	biological_process	response to toxic substance
G	0010248	biological_process	establishment or maintenance of transmembrane electrochemical gradient
G	0010917	biological_process	negative regulation of mitochondrial membrane potential
G	0015267	molecular_function	channel activity
G	0016020	cellular_component	membrane
G	0030544	molecular_function	Hsp70 protein binding
G	0031334	biological_process	positive regulation of protein-containing complex assembly
G	0031966	cellular_component	mitochondrial membrane
G	0032091	biological_process	negative regulation of protein binding
G	0032469	biological_process	endoplasmic reticulum calcium ion homeostasis
G	0032976	biological_process	release of matrix enzymes from mitochondria
G	0033554	biological_process	cellular response to stress
G	0034620	biological_process	cellular response to unfolded protein
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0042981	biological_process	regulation of apoptotic process
G	0043065	biological_process	positive regulation of apoptotic process
G	0043525	biological_process	positive regulation of neuron apoptotic process
G	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
G	0046930	cellular_component	pore complex
G	0046982	molecular_function	protein heterodimerization activity
G	0051087	molecular_function	protein-folding chaperone binding
G	0051434	molecular_function	BH3 domain binding
G	0051881	biological_process	regulation of mitochondrial membrane potential
G	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
G	0070062	cellular_component	extracellular exosome
G	0071944	cellular_component	cell periphery
G	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
G	0097136	cellular_component	Bcl-2 family protein complex
G	0097144	cellular_component	BAX complex
G	0097145	cellular_component	BAK complex
G	0097190	biological_process	apoptotic signaling pathway
G	0097191	biological_process	extrinsic apoptotic signaling pathway
G	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
G	0097193	biological_process	intrinsic apoptotic signaling pathway
G	0097194	biological_process	execution phase of apoptosis
G	0097435	biological_process	supramolecular fiber organization
G	0098586	biological_process	cellular response to virus
G	1902512	biological_process	positive regulation of apoptotic DNA fragmentation
G	1902531	biological_process	regulation of intracellular signal transduction
G	1903896	biological_process	positive regulation of IRE1-mediated unfolded protein response
G	1990117	biological_process	B cell receptor apoptotic signaling pathway
G	2001233	biological_process	regulation of apoptotic signaling pathway
G	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
H	0001783	biological_process	B cell apoptotic process
H	0001836	biological_process	release of cytochrome c from mitochondria
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005635	cellular_component	nuclear envelope
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005741	cellular_component	mitochondrial outer membrane
H	0005757	cellular_component	mitochondrial permeability transition pore complex
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0005829	cellular_component	cytosol
H	0006915	biological_process	apoptotic process
H	0008053	biological_process	mitochondrial fusion
H	0008289	molecular_function	lipid binding
H	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
H	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
H	0008637	biological_process	apoptotic mitochondrial changes
H	0009636	biological_process	response to toxic substance
H	0010248	biological_process	establishment or maintenance of transmembrane electrochemical gradient
H	0010917	biological_process	negative regulation of mitochondrial membrane potential
H	0015267	molecular_function	channel activity
H	0016020	cellular_component	membrane
H	0030544	molecular_function	Hsp70 protein binding
H	0031334	biological_process	positive regulation of protein-containing complex assembly
H	0031966	cellular_component	mitochondrial membrane
H	0032091	biological_process	negative regulation of protein binding
H	0032469	biological_process	endoplasmic reticulum calcium ion homeostasis
H	0032976	biological_process	release of matrix enzymes from mitochondria
H	0033554	biological_process	cellular response to stress
H	0034620	biological_process	cellular response to unfolded protein
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0042981	biological_process	regulation of apoptotic process
H	0043065	biological_process	positive regulation of apoptotic process
H	0043525	biological_process	positive regulation of neuron apoptotic process
H	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
H	0046930	cellular_component	pore complex
H	0046982	molecular_function	protein heterodimerization activity
H	0051087	molecular_function	protein-folding chaperone binding
H	0051434	molecular_function	BH3 domain binding
H	0051881	biological_process	regulation of mitochondrial membrane potential
H	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
H	0070062	cellular_component	extracellular exosome
H	0071944	cellular_component	cell periphery
H	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
H	0097136	cellular_component	Bcl-2 family protein complex
H	0097144	cellular_component	BAX complex
H	0097145	cellular_component	BAK complex
H	0097190	biological_process	apoptotic signaling pathway
H	0097191	biological_process	extrinsic apoptotic signaling pathway
H	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
H	0097193	biological_process	intrinsic apoptotic signaling pathway
H	0097194	biological_process	execution phase of apoptosis
H	0097435	biological_process	supramolecular fiber organization
H	0098586	biological_process	cellular response to virus
H	1902512	biological_process	positive regulation of apoptotic DNA fragmentation
H	1902531	biological_process	regulation of intracellular signal transduction
H	1903896	biological_process	positive regulation of IRE1-mediated unfolded protein response
H	1990117	biological_process	B cell receptor apoptotic signaling pathway
H	2001233	biological_process	regulation of apoptotic signaling pathway
H	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS01080
Number of Residues	20
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. MFsDGnfNWGRVVALFyFAS

Chain	Residue	Details
A	MET99-SER118

---

site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdqGGWDgLL

Chain	Residue	Details
A	TRP151-LEU162

---

site_id	PS01259
Number of Residues	15
Details	BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. LsecLKrIGDELDSN

Chain	Residue	Details
A	LEU59-ASN73

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	Motif: {"description":"BH3","evidences":[{"source":"PubMed","id":"8521816","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	80
Details	Motif: {"description":"BH1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	30
Details	Motif: {"description":"BH2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36361894","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	40
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---