Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
Functional Information from PROSITE/UniProt
| site_id | PS00766 |
| Number of Residues | 26 |
| Details | THF_DHG_CYH_1 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. EsEVMkyItsLNeDstvhgFLVQLPL |
| Chain | Residue | Details |
| A | GLU78-LEU103 |
| site_id | PS00767 |
| Number of Residues | 9 |
| Details | THF_DHG_CYH_2 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. PGGVGPMTV |
| Chain | Residue | Details |
| A | PRO272-VAL280 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"10828945","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10828945","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DIA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DIB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10828945","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9519408","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DIA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DIB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DIG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 389 |
| Chain | Residue | Details |
| A | LYS56 | activator |
| A | GLN100 | activator |
| A | ASP125 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 458 |
| Chain | Residue | Details |
| A | SER49 | activator |
| A | LYS56 | proton shuttle (general acid/base) |
| A | GLN100 | activator |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 389 |
| Chain | Residue | Details |
| B | LYS56 | activator |
| B | GLN100 | activator |
| B | ASP125 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 3 |
| Details | M-CSA 458 |
| Chain | Residue | Details |
| B | SER49 | activator |
| B | LYS56 | proton shuttle (general acid/base) |
| B | GLN100 | activator |
| site_id | MCSA5 |
| Number of Residues | 3 |
| Details | M-CSA 389 |
| Chain | Residue | Details |
| C | LYS56 | activator |
| C | GLN100 | activator |
| C | ASP125 | electrostatic stabiliser |
| site_id | MCSA6 |
| Number of Residues | 3 |
| Details | M-CSA 458 |
| Chain | Residue | Details |
| C | SER49 | activator |
| C | LYS56 | proton shuttle (general acid/base) |
| C | GLN100 | activator |
| site_id | MCSA7 |
| Number of Residues | 3 |
| Details | M-CSA 389 |
| Chain | Residue | Details |
| D | LYS56 | activator |
| D | GLN100 | activator |
| D | ASP125 | electrostatic stabiliser |
| site_id | MCSA8 |
| Number of Residues | 3 |
| Details | M-CSA 458 |
| Chain | Residue | Details |
| D | SER49 | activator |
| D | LYS56 | proton shuttle (general acid/base) |
| D | GLN100 | activator |
