9ISI
Structure of human C3aR in apo state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0004875 | molecular_function | complement receptor activity |
| B | 0004876 | molecular_function | complement component C3a receptor activity |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0006935 | biological_process | chemotaxis |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016020 | cellular_component | membrane |
| B | 0020037 | molecular_function | heme binding |
| B | 0022900 | biological_process | electron transport chain |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVfLLTAISLDRCLvV |
| Chain | Residue | Details |
| B | ALA108-VAL124 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J6D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J6D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J6D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J6D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J6D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J6D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 7 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J6D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J6D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"38175886","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JA3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
