9IPY

Structure of JR14a-bound human C3aR

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
R	0004875	molecular_function	complement receptor activity
R	0004876	molecular_function	complement component C3a receptor activity
R	0004930	molecular_function	G protein-coupled receptor activity
R	0005506	molecular_function	iron ion binding
R	0006935	biological_process	chemotaxis
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0009055	molecular_function	electron transfer activity
R	0016020	cellular_component	membrane
R	0020037	molecular_function	heme binding
R	0022900	biological_process	electron transport chain
R	0042597	cellular_component	periplasmic space

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVfLLTAISLDRCLvV

Chain	Residue	Details
R	ALA108-VAL124

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J6D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	33
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J6D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J6D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J6D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J6D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J6D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J6D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	7
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J6D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8I9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J6D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Sulfotyrosine","evidences":[{"source":"PubMed","id":"12871936","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"38175886","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JA3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---