9IOV

Gossypol bound lactate dehydrogenase A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004457	molecular_function	lactate dehydrogenase activity
A	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006089	biological_process	lactate metabolic process
A	0006096	biological_process	glycolytic process
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0035686	cellular_component	sperm fibrous sheath
A	0042802	molecular_function	identical protein binding
A	0042867	biological_process	pyruvate catabolic process
A	0045296	molecular_function	cadherin binding
A	0070062	cellular_component	extracellular exosome
B	0004457	molecular_function	lactate dehydrogenase activity
B	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006089	biological_process	lactate metabolic process
B	0006096	biological_process	glycolytic process
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0035686	cellular_component	sperm fibrous sheath
B	0042802	molecular_function	identical protein binding
B	0042867	biological_process	pyruvate catabolic process
B	0045296	molecular_function	cadherin binding
B	0070062	cellular_component	extracellular exosome
C	0004457	molecular_function	lactate dehydrogenase activity
C	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006089	biological_process	lactate metabolic process
C	0006096	biological_process	glycolytic process
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0035686	cellular_component	sperm fibrous sheath
C	0042802	molecular_function	identical protein binding
C	0042867	biological_process	pyruvate catabolic process
C	0045296	molecular_function	cadherin binding
C	0070062	cellular_component	extracellular exosome
D	0004457	molecular_function	lactate dehydrogenase activity
D	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006089	biological_process	lactate metabolic process
D	0006096	biological_process	glycolytic process
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0035686	cellular_component	sperm fibrous sheath
D	0042802	molecular_function	identical protein binding
D	0042867	biological_process	pyruvate catabolic process
D	0045296	molecular_function	cadherin binding
D	0070062	cellular_component	extracellular exosome
E	0004457	molecular_function	lactate dehydrogenase activity
E	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0006089	biological_process	lactate metabolic process
E	0006096	biological_process	glycolytic process
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0035686	cellular_component	sperm fibrous sheath
E	0042802	molecular_function	identical protein binding
E	0042867	biological_process	pyruvate catabolic process
E	0045296	molecular_function	cadherin binding
E	0070062	cellular_component	extracellular exosome
F	0004457	molecular_function	lactate dehydrogenase activity
F	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0006089	biological_process	lactate metabolic process
F	0006096	biological_process	glycolytic process
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0035686	cellular_component	sperm fibrous sheath
F	0042802	molecular_function	identical protein binding
F	0042867	biological_process	pyruvate catabolic process
F	0045296	molecular_function	cadherin binding
F	0070062	cellular_component	extracellular exosome
G	0004457	molecular_function	lactate dehydrogenase activity
G	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005829	cellular_component	cytosol
G	0006089	biological_process	lactate metabolic process
G	0006096	biological_process	glycolytic process
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0035686	cellular_component	sperm fibrous sheath
G	0042802	molecular_function	identical protein binding
G	0042867	biological_process	pyruvate catabolic process
G	0045296	molecular_function	cadherin binding
G	0070062	cellular_component	extracellular exosome
H	0004457	molecular_function	lactate dehydrogenase activity
H	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005829	cellular_component	cytosol
H	0006089	biological_process	lactate metabolic process
H	0006096	biological_process	glycolytic process
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0035686	cellular_component	sperm fibrous sheath
H	0042802	molecular_function	identical protein binding
H	0042867	biological_process	pyruvate catabolic process
H	0045296	molecular_function	cadherin binding
H	0070062	cellular_component	extracellular exosome
I	0004457	molecular_function	lactate dehydrogenase activity
I	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005829	cellular_component	cytosol
I	0006089	biological_process	lactate metabolic process
I	0006096	biological_process	glycolytic process
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0035686	cellular_component	sperm fibrous sheath
I	0042802	molecular_function	identical protein binding
I	0042867	biological_process	pyruvate catabolic process
I	0045296	molecular_function	cadherin binding
I	0070062	cellular_component	extracellular exosome
J	0004457	molecular_function	lactate dehydrogenase activity
J	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005829	cellular_component	cytosol
J	0006089	biological_process	lactate metabolic process
J	0006096	biological_process	glycolytic process
J	0016020	cellular_component	membrane
J	0016491	molecular_function	oxidoreductase activity
J	0035686	cellular_component	sperm fibrous sheath
J	0042802	molecular_function	identical protein binding
J	0042867	biological_process	pyruvate catabolic process
J	0045296	molecular_function	cadherin binding
J	0070062	cellular_component	extracellular exosome
K	0004457	molecular_function	lactate dehydrogenase activity
K	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005829	cellular_component	cytosol
K	0006089	biological_process	lactate metabolic process
K	0006096	biological_process	glycolytic process
K	0016020	cellular_component	membrane
K	0016491	molecular_function	oxidoreductase activity
K	0035686	cellular_component	sperm fibrous sheath
K	0042802	molecular_function	identical protein binding
K	0042867	biological_process	pyruvate catabolic process
K	0045296	molecular_function	cadherin binding
K	0070062	cellular_component	extracellular exosome
L	0004457	molecular_function	lactate dehydrogenase activity
L	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005829	cellular_component	cytosol
L	0006089	biological_process	lactate metabolic process
L	0006096	biological_process	glycolytic process
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
L	0035686	cellular_component	sperm fibrous sheath
L	0042802	molecular_function	identical protein binding
L	0042867	biological_process	pyruvate catabolic process
L	0045296	molecular_function	cadherin binding
L	0070062	cellular_component	extracellular exosome
M	0004457	molecular_function	lactate dehydrogenase activity
M	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005829	cellular_component	cytosol
M	0006089	biological_process	lactate metabolic process
M	0006096	biological_process	glycolytic process
M	0016020	cellular_component	membrane
M	0016491	molecular_function	oxidoreductase activity
M	0035686	cellular_component	sperm fibrous sheath
M	0042802	molecular_function	identical protein binding
M	0042867	biological_process	pyruvate catabolic process
M	0045296	molecular_function	cadherin binding
M	0070062	cellular_component	extracellular exosome
N	0004457	molecular_function	lactate dehydrogenase activity
N	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005739	cellular_component	mitochondrion
N	0005829	cellular_component	cytosol
N	0006089	biological_process	lactate metabolic process
N	0006096	biological_process	glycolytic process
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0035686	cellular_component	sperm fibrous sheath
N	0042802	molecular_function	identical protein binding
N	0042867	biological_process	pyruvate catabolic process
N	0045296	molecular_function	cadherin binding
N	0070062	cellular_component	extracellular exosome
O	0004457	molecular_function	lactate dehydrogenase activity
O	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005739	cellular_component	mitochondrion
O	0005829	cellular_component	cytosol
O	0006089	biological_process	lactate metabolic process
O	0006096	biological_process	glycolytic process
O	0016020	cellular_component	membrane
O	0016491	molecular_function	oxidoreductase activity
O	0035686	cellular_component	sperm fibrous sheath
O	0042802	molecular_function	identical protein binding
O	0042867	biological_process	pyruvate catabolic process
O	0045296	molecular_function	cadherin binding
O	0070062	cellular_component	extracellular exosome
P	0004457	molecular_function	lactate dehydrogenase activity
P	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005739	cellular_component	mitochondrion
P	0005829	cellular_component	cytosol
P	0006089	biological_process	lactate metabolic process
P	0006096	biological_process	glycolytic process
P	0016020	cellular_component	membrane
P	0016491	molecular_function	oxidoreductase activity
P	0035686	cellular_component	sperm fibrous sheath
P	0042802	molecular_function	identical protein binding
P	0042867	biological_process	pyruvate catabolic process
P	0045296	molecular_function	cadherin binding
P	0070062	cellular_component	extracellular exosome
Q	0004457	molecular_function	lactate dehydrogenase activity
Q	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0005739	cellular_component	mitochondrion
Q	0005829	cellular_component	cytosol
Q	0006089	biological_process	lactate metabolic process
Q	0006096	biological_process	glycolytic process
Q	0016020	cellular_component	membrane
Q	0016491	molecular_function	oxidoreductase activity
Q	0035686	cellular_component	sperm fibrous sheath
Q	0042802	molecular_function	identical protein binding
Q	0042867	biological_process	pyruvate catabolic process
Q	0045296	molecular_function	cadherin binding
Q	0070062	cellular_component	extracellular exosome
R	0004457	molecular_function	lactate dehydrogenase activity
R	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0005739	cellular_component	mitochondrion
R	0005829	cellular_component	cytosol
R	0006089	biological_process	lactate metabolic process
R	0006096	biological_process	glycolytic process
R	0016020	cellular_component	membrane
R	0016491	molecular_function	oxidoreductase activity
R	0035686	cellular_component	sperm fibrous sheath
R	0042802	molecular_function	identical protein binding
R	0042867	biological_process	pyruvate catabolic process
R	0045296	molecular_function	cadherin binding
R	0070062	cellular_component	extracellular exosome
S	0004457	molecular_function	lactate dehydrogenase activity
S	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0005739	cellular_component	mitochondrion
S	0005829	cellular_component	cytosol
S	0006089	biological_process	lactate metabolic process
S	0006096	biological_process	glycolytic process
S	0016020	cellular_component	membrane
S	0016491	molecular_function	oxidoreductase activity
S	0035686	cellular_component	sperm fibrous sheath
S	0042802	molecular_function	identical protein binding
S	0042867	biological_process	pyruvate catabolic process
S	0045296	molecular_function	cadherin binding
S	0070062	cellular_component	extracellular exosome
T	0004457	molecular_function	lactate dehydrogenase activity
T	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005737	cellular_component	cytoplasm
T	0005739	cellular_component	mitochondrion
T	0005829	cellular_component	cytosol
T	0006089	biological_process	lactate metabolic process
T	0006096	biological_process	glycolytic process
T	0016020	cellular_component	membrane
T	0016491	molecular_function	oxidoreductase activity
T	0035686	cellular_component	sperm fibrous sheath
T	0042802	molecular_function	identical protein binding
T	0042867	biological_process	pyruvate catabolic process
T	0045296	molecular_function	cadherin binding
T	0070062	cellular_component	extracellular exosome
U	0004457	molecular_function	lactate dehydrogenase activity
U	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005737	cellular_component	cytoplasm
U	0005739	cellular_component	mitochondrion
U	0005829	cellular_component	cytosol
U	0006089	biological_process	lactate metabolic process
U	0006096	biological_process	glycolytic process
U	0016020	cellular_component	membrane
U	0016491	molecular_function	oxidoreductase activity
U	0035686	cellular_component	sperm fibrous sheath
U	0042802	molecular_function	identical protein binding
U	0042867	biological_process	pyruvate catabolic process
U	0045296	molecular_function	cadherin binding
U	0070062	cellular_component	extracellular exosome
V	0004457	molecular_function	lactate dehydrogenase activity
V	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005737	cellular_component	cytoplasm
V	0005739	cellular_component	mitochondrion
V	0005829	cellular_component	cytosol
V	0006089	biological_process	lactate metabolic process
V	0006096	biological_process	glycolytic process
V	0016020	cellular_component	membrane
V	0016491	molecular_function	oxidoreductase activity
V	0035686	cellular_component	sperm fibrous sheath
V	0042802	molecular_function	identical protein binding
V	0042867	biological_process	pyruvate catabolic process
V	0045296	molecular_function	cadherin binding
V	0070062	cellular_component	extracellular exosome
W	0004457	molecular_function	lactate dehydrogenase activity
W	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005737	cellular_component	cytoplasm
W	0005739	cellular_component	mitochondrion
W	0005829	cellular_component	cytosol
W	0006089	biological_process	lactate metabolic process
W	0006096	biological_process	glycolytic process
W	0016020	cellular_component	membrane
W	0016491	molecular_function	oxidoreductase activity
W	0035686	cellular_component	sperm fibrous sheath
W	0042802	molecular_function	identical protein binding
W	0042867	biological_process	pyruvate catabolic process
W	0045296	molecular_function	cadherin binding
W	0070062	cellular_component	extracellular exosome
X	0004457	molecular_function	lactate dehydrogenase activity
X	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
X	0005739	cellular_component	mitochondrion
X	0005829	cellular_component	cytosol
X	0006089	biological_process	lactate metabolic process
X	0006096	biological_process	glycolytic process
X	0016020	cellular_component	membrane
X	0016491	molecular_function	oxidoreductase activity
X	0035686	cellular_component	sperm fibrous sheath
X	0042802	molecular_function	identical protein binding
X	0042867	biological_process	pyruvate catabolic process
X	0045296	molecular_function	cadherin binding
X	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00064
Number of Residues	7
Details	L_LDH L-lactate dehydrogenase active site. LGEHGDS

Chain	Residue	Details
A	LEU189-SER195

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	696
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11276087","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	96
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	72
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P06151","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	72
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	24
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	24
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	72
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P06151","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	24
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P06151","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	48
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P04642","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	24
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	48
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---