9IJY
Homo sapiens Xenotropic and Polytropic Retrovirus Receptor 1 (XPR1) with Y22A/E23A/K26A mutations
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000822 | molecular_function | inositol hexakisphosphate binding |
| A | 0001618 | molecular_function | virus receptor activity |
| A | 0005315 | molecular_function | phosphate transmembrane transporter activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006817 | biological_process | phosphate ion transport |
| A | 0009615 | biological_process | response to virus |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016036 | biological_process | cellular response to phosphate starvation |
| A | 0030643 | biological_process | intracellular phosphate ion homeostasis |
| A | 0035435 | biological_process | phosphate ion transmembrane transport |
| A | 0046718 | biological_process | symbiont entry into host cell |
| B | 0000822 | molecular_function | inositol hexakisphosphate binding |
| B | 0001618 | molecular_function | virus receptor activity |
| B | 0005315 | molecular_function | phosphate transmembrane transporter activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006817 | biological_process | phosphate ion transport |
| B | 0009615 | biological_process | response to virus |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016036 | biological_process | cellular response to phosphate starvation |
| B | 0030643 | biological_process | intracellular phosphate ion homeostasis |
| B | 0035435 | biological_process | phosphate ion transmembrane transport |
| B | 0046718 | biological_process | symbiont entry into host cell |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 980 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-ARG236 | |
| B | ASP529-THR696 | |
| A | GLY286-GLU318 | |
| A | LYS369-LYS376 | |
| A | ASP424-ALA473 | |
| A | ASP529-THR696 | |
| B | MET1-ARG236 | |
| B | GLY286-GLU318 | |
| B | LYS369-LYS376 | |
| B | ASP424-ALA473 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 328 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL237-PHE257 | |
| B | ILE265-LEU285 | |
| B | ILE319-ILE339 | |
| B | VAL346-TYR368 | |
| B | LEU377-ALA397 | |
| B | LEU403-TRP423 | |
| B | PHE474-TYR496 | |
| B | MET508-TRP528 | |
| A | ILE265-LEU285 | |
| A | ILE319-ILE339 | |
| A | VAL346-TYR368 | |
| A | LEU377-ALA397 | |
| A | LEU403-TRP423 | |
| A | PHE474-TYR496 | |
| A | MET508-TRP528 | |
| B | VAL237-PHE257 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 50 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS258-SER264 | |
| A | SER340-TYR345 | |
| A | ASP398-SER402 | |
| A | SER497-THR507 | |
| B | LYS258-SER264 | |
| B | SER340-TYR345 | |
| B | ASP398-SER402 | |
| B | SER497-THR507 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Important for inositol polyphosphate binding => ECO:0000305|PubMed:27080106 |
| Chain | Residue | Details |
| A | ALA22 | |
| A | ALA26 | |
| B | ALA22 | |
| B | ALA26 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER668 | |
| B | SER668 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | THR690 | |
| B | THR690 |
