9IJP

Polyphosphate bound alpha-synuclein fibril

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000149	molecular_function	SNARE binding
B	0000287	molecular_function	magnesium ion binding
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0001774	biological_process	microglial cell activation
B	0001921	biological_process	positive regulation of receptor recycling
B	0001956	biological_process	positive regulation of neurotransmitter secretion
B	0001963	biological_process	synaptic transmission, dopaminergic
B	0003779	molecular_function	actin binding
B	0004860	molecular_function	protein kinase inhibitor activity
B	0005504	molecular_function	fatty acid binding
B	0005507	molecular_function	copper ion binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005543	molecular_function	phospholipid binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005764	cellular_component	lysosome
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005886	cellular_component	plasma membrane
B	0005938	cellular_component	cell cortex
B	0006469	biological_process	negative regulation of protein kinase activity
B	0006631	biological_process	fatty acid metabolic process
B	0006638	biological_process	neutral lipid metabolic process
B	0006644	biological_process	phospholipid metabolic process
B	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
B	0007006	biological_process	mitochondrial membrane organization
B	0007268	biological_process	chemical synaptic transmission
B	0007269	biological_process	neurotransmitter secretion
B	0008198	molecular_function	ferrous iron binding
B	0008270	molecular_function	zinc ion binding
B	0008289	molecular_function	lipid binding
B	0008344	biological_process	adult locomotory behavior
B	0009410	biological_process	response to xenobiotic stimulus
B	0010040	biological_process	response to iron(II) ion
B	0010517	biological_process	regulation of phospholipase activity
B	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
B	0014048	biological_process	regulation of glutamate secretion
B	0014059	biological_process	regulation of dopamine secretion
B	0015629	cellular_component	actin cytoskeleton
B	0016020	cellular_component	membrane
B	0016079	biological_process	synaptic vesicle exocytosis
B	0016082	biological_process	synaptic vesicle priming
B	0016234	cellular_component	inclusion body
B	0016491	molecular_function	oxidoreductase activity
B	0019894	molecular_function	kinesin binding
B	0022898	biological_process	regulation of transmembrane transporter activity
B	0030424	cellular_component	axon
B	0030426	cellular_component	growth cone
B	0030544	molecular_function	Hsp70 protein binding
B	0030672	cellular_component	synaptic vesicle membrane
B	0031092	cellular_component	platelet alpha granule membrane
B	0031115	biological_process	negative regulation of microtubule polymerization
B	0031623	biological_process	receptor internalization
B	0031648	biological_process	protein destabilization
B	0032026	biological_process	response to magnesium ion
B	0032410	biological_process	negative regulation of transporter activity
B	0032496	biological_process	response to lipopolysaccharide
B	0032769	biological_process	negative regulation of monooxygenase activity
B	0032991	cellular_component	protein-containing complex
B	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
B	0034341	biological_process	response to type II interferon
B	0034599	biological_process	cellular response to oxidative stress
B	0035493	biological_process	SNARE complex assembly
B	0035543	biological_process	positive regulation of SNARE complex assembly
B	0040012	biological_process	regulation of locomotion
B	0042393	molecular_function	histone binding
B	0042416	biological_process	dopamine biosynthetic process
B	0042417	biological_process	dopamine metabolic process
B	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
B	0042802	molecular_function	identical protein binding
B	0042995	cellular_component	cell projection
B	0043014	molecular_function	alpha-tubulin binding
B	0043025	cellular_component	neuronal cell body
B	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
B	0043030	biological_process	regulation of macrophage activation
B	0043065	biological_process	positive regulation of apoptotic process
B	0043066	biological_process	negative regulation of apoptotic process
B	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
B	0043524	biological_process	negative regulation of neuron apoptotic process
B	0043679	cellular_component	axon terminus
B	0045202	cellular_component	synapse
B	0045807	biological_process	positive regulation of endocytosis
B	0045920	biological_process	negative regulation of exocytosis
B	0045921	biological_process	positive regulation of exocytosis
B	0046872	molecular_function	metal ion binding
B	0046928	biological_process	regulation of neurotransmitter secretion
B	0048156	molecular_function	tau protein binding
B	0048168	biological_process	regulation of neuronal synaptic plasticity
B	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0048488	biological_process	synaptic vesicle endocytosis
B	0048489	biological_process	synaptic vesicle transport
B	0050729	biological_process	positive regulation of inflammatory response
B	0050806	biological_process	positive regulation of synaptic transmission
B	0050808	biological_process	synapse organization
B	0050812	biological_process	regulation of acyl-CoA biosynthetic process
B	0051219	molecular_function	phosphoprotein binding
B	0051259	biological_process	protein complex oligomerization
B	0051262	biological_process	protein tetramerization
B	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
B	0051402	biological_process	neuron apoptotic process
B	0051583	biological_process	dopamine uptake involved in synaptic transmission
B	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
B	0051612	biological_process	negative regulation of serotonin uptake
B	0051621	biological_process	regulation of norepinephrine uptake
B	0051622	biological_process	negative regulation of norepinephrine uptake
B	0055074	biological_process	calcium ion homeostasis
B	0060079	biological_process	excitatory postsynaptic potential
B	0060090	molecular_function	molecular adaptor activity
B	0060291	biological_process	long-term synaptic potentiation
B	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
B	0060961	molecular_function	phospholipase D inhibitor activity
B	0061024	biological_process	membrane organization
B	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
B	0070555	biological_process	response to interleukin-1
B	0070840	molecular_function	dynein complex binding
B	0071280	biological_process	cellular response to copper ion
B	0071872	biological_process	cellular response to epinephrine stimulus
B	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
B	0097435	biological_process	supramolecular fiber organization
B	0098794	cellular_component	postsynapse
B	0099512	cellular_component	supramolecular fiber
B	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
B	1903136	molecular_function	cuprous ion binding
B	1903284	biological_process	positive regulation of glutathione peroxidase activity
B	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
B	1903421	biological_process	regulation of synaptic vesicle recycling
B	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
B	1904377	biological_process	positive regulation of protein localization to cell periphery
B	1904715	biological_process	negative regulation of chaperone-mediated autophagy
B	1905606	biological_process	regulation of presynapse assembly
B	1990000	biological_process	amyloid fibril formation
B	2000377	biological_process	regulation of reactive oxygen species metabolic process
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000149	molecular_function	SNARE binding
C	0000287	molecular_function	magnesium ion binding
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0001774	biological_process	microglial cell activation
C	0001921	biological_process	positive regulation of receptor recycling
C	0001956	biological_process	positive regulation of neurotransmitter secretion
C	0001963	biological_process	synaptic transmission, dopaminergic
C	0003779	molecular_function	actin binding
C	0004860	molecular_function	protein kinase inhibitor activity
C	0005504	molecular_function	fatty acid binding
C	0005507	molecular_function	copper ion binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005543	molecular_function	phospholipid binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005764	cellular_component	lysosome
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0005938	cellular_component	cell cortex
C	0006469	biological_process	negative regulation of protein kinase activity
C	0006631	biological_process	fatty acid metabolic process
C	0006638	biological_process	neutral lipid metabolic process
C	0006644	biological_process	phospholipid metabolic process
C	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
C	0007006	biological_process	mitochondrial membrane organization
C	0007268	biological_process	chemical synaptic transmission
C	0007269	biological_process	neurotransmitter secretion
C	0008198	molecular_function	ferrous iron binding
C	0008270	molecular_function	zinc ion binding
C	0008289	molecular_function	lipid binding
C	0008344	biological_process	adult locomotory behavior
C	0009410	biological_process	response to xenobiotic stimulus
C	0010040	biological_process	response to iron(II) ion
C	0010517	biological_process	regulation of phospholipase activity
C	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
C	0014048	biological_process	regulation of glutamate secretion
C	0014059	biological_process	regulation of dopamine secretion
C	0015629	cellular_component	actin cytoskeleton
C	0016020	cellular_component	membrane
C	0016079	biological_process	synaptic vesicle exocytosis
C	0016082	biological_process	synaptic vesicle priming
C	0016234	cellular_component	inclusion body
C	0016491	molecular_function	oxidoreductase activity
C	0019894	molecular_function	kinesin binding
C	0022898	biological_process	regulation of transmembrane transporter activity
C	0030424	cellular_component	axon
C	0030426	cellular_component	growth cone
C	0030544	molecular_function	Hsp70 protein binding
C	0030672	cellular_component	synaptic vesicle membrane
C	0031092	cellular_component	platelet alpha granule membrane
C	0031115	biological_process	negative regulation of microtubule polymerization
C	0031623	biological_process	receptor internalization
C	0031648	biological_process	protein destabilization
C	0032026	biological_process	response to magnesium ion
C	0032410	biological_process	negative regulation of transporter activity
C	0032496	biological_process	response to lipopolysaccharide
C	0032769	biological_process	negative regulation of monooxygenase activity
C	0032991	cellular_component	protein-containing complex
C	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
C	0034341	biological_process	response to type II interferon
C	0034599	biological_process	cellular response to oxidative stress
C	0035493	biological_process	SNARE complex assembly
C	0035543	biological_process	positive regulation of SNARE complex assembly
C	0040012	biological_process	regulation of locomotion
C	0042393	molecular_function	histone binding
C	0042416	biological_process	dopamine biosynthetic process
C	0042417	biological_process	dopamine metabolic process
C	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
C	0042802	molecular_function	identical protein binding
C	0042995	cellular_component	cell projection
C	0043014	molecular_function	alpha-tubulin binding
C	0043025	cellular_component	neuronal cell body
C	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
C	0043030	biological_process	regulation of macrophage activation
C	0043065	biological_process	positive regulation of apoptotic process
C	0043066	biological_process	negative regulation of apoptotic process
C	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
C	0043524	biological_process	negative regulation of neuron apoptotic process
C	0043679	cellular_component	axon terminus
C	0045202	cellular_component	synapse
C	0045807	biological_process	positive regulation of endocytosis
C	0045920	biological_process	negative regulation of exocytosis
C	0045921	biological_process	positive regulation of exocytosis
C	0046872	molecular_function	metal ion binding
C	0046928	biological_process	regulation of neurotransmitter secretion
C	0048156	molecular_function	tau protein binding
C	0048168	biological_process	regulation of neuronal synaptic plasticity
C	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0048488	biological_process	synaptic vesicle endocytosis
C	0048489	biological_process	synaptic vesicle transport
C	0050729	biological_process	positive regulation of inflammatory response
C	0050806	biological_process	positive regulation of synaptic transmission
C	0050808	biological_process	synapse organization
C	0050812	biological_process	regulation of acyl-CoA biosynthetic process
C	0051219	molecular_function	phosphoprotein binding
C	0051259	biological_process	protein complex oligomerization
C	0051262	biological_process	protein tetramerization
C	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
C	0051402	biological_process	neuron apoptotic process
C	0051583	biological_process	dopamine uptake involved in synaptic transmission
C	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
C	0051612	biological_process	negative regulation of serotonin uptake
C	0051621	biological_process	regulation of norepinephrine uptake
C	0051622	biological_process	negative regulation of norepinephrine uptake
C	0055074	biological_process	calcium ion homeostasis
C	0060079	biological_process	excitatory postsynaptic potential
C	0060090	molecular_function	molecular adaptor activity
C	0060291	biological_process	long-term synaptic potentiation
C	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
C	0060961	molecular_function	phospholipase D inhibitor activity
C	0061024	biological_process	membrane organization
C	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
C	0070555	biological_process	response to interleukin-1
C	0070840	molecular_function	dynein complex binding
C	0071280	biological_process	cellular response to copper ion
C	0071872	biological_process	cellular response to epinephrine stimulus
C	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
C	0097435	biological_process	supramolecular fiber organization
C	0098794	cellular_component	postsynapse
C	0099512	cellular_component	supramolecular fiber
C	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
C	1903136	molecular_function	cuprous ion binding
C	1903284	biological_process	positive regulation of glutathione peroxidase activity
C	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
C	1903421	biological_process	regulation of synaptic vesicle recycling
C	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
C	1904377	biological_process	positive regulation of protein localization to cell periphery
C	1904715	biological_process	negative regulation of chaperone-mediated autophagy
C	1905606	biological_process	regulation of presynapse assembly
C	1990000	biological_process	amyloid fibril formation
C	2000377	biological_process	regulation of reactive oxygen species metabolic process
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000149	molecular_function	SNARE binding
E	0000287	molecular_function	magnesium ion binding
E	0000976	molecular_function	transcription cis-regulatory region binding
E	0001774	biological_process	microglial cell activation
E	0001921	biological_process	positive regulation of receptor recycling
E	0001956	biological_process	positive regulation of neurotransmitter secretion
E	0001963	biological_process	synaptic transmission, dopaminergic
E	0003779	molecular_function	actin binding
E	0004860	molecular_function	protein kinase inhibitor activity
E	0005504	molecular_function	fatty acid binding
E	0005507	molecular_function	copper ion binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005543	molecular_function	phospholipid binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005764	cellular_component	lysosome
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005886	cellular_component	plasma membrane
E	0005938	cellular_component	cell cortex
E	0006469	biological_process	negative regulation of protein kinase activity
E	0006631	biological_process	fatty acid metabolic process
E	0006638	biological_process	neutral lipid metabolic process
E	0006644	biological_process	phospholipid metabolic process
E	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
E	0007006	biological_process	mitochondrial membrane organization
E	0007268	biological_process	chemical synaptic transmission
E	0007269	biological_process	neurotransmitter secretion
E	0008198	molecular_function	ferrous iron binding
E	0008270	molecular_function	zinc ion binding
E	0008289	molecular_function	lipid binding
E	0008344	biological_process	adult locomotory behavior
E	0009410	biological_process	response to xenobiotic stimulus
E	0010040	biological_process	response to iron(II) ion
E	0010517	biological_process	regulation of phospholipase activity
E	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
E	0014048	biological_process	regulation of glutamate secretion
E	0014059	biological_process	regulation of dopamine secretion
E	0015629	cellular_component	actin cytoskeleton
E	0016020	cellular_component	membrane
E	0016079	biological_process	synaptic vesicle exocytosis
E	0016082	biological_process	synaptic vesicle priming
E	0016234	cellular_component	inclusion body
E	0016491	molecular_function	oxidoreductase activity
E	0019894	molecular_function	kinesin binding
E	0022898	biological_process	regulation of transmembrane transporter activity
E	0030424	cellular_component	axon
E	0030426	cellular_component	growth cone
E	0030544	molecular_function	Hsp70 protein binding
E	0030672	cellular_component	synaptic vesicle membrane
E	0031092	cellular_component	platelet alpha granule membrane
E	0031115	biological_process	negative regulation of microtubule polymerization
E	0031623	biological_process	receptor internalization
E	0031648	biological_process	protein destabilization
E	0032026	biological_process	response to magnesium ion
E	0032410	biological_process	negative regulation of transporter activity
E	0032496	biological_process	response to lipopolysaccharide
E	0032769	biological_process	negative regulation of monooxygenase activity
E	0032991	cellular_component	protein-containing complex
E	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
E	0034341	biological_process	response to type II interferon
E	0034599	biological_process	cellular response to oxidative stress
E	0035493	biological_process	SNARE complex assembly
E	0035543	biological_process	positive regulation of SNARE complex assembly
E	0040012	biological_process	regulation of locomotion
E	0042393	molecular_function	histone binding
E	0042416	biological_process	dopamine biosynthetic process
E	0042417	biological_process	dopamine metabolic process
E	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
E	0042802	molecular_function	identical protein binding
E	0042995	cellular_component	cell projection
E	0043014	molecular_function	alpha-tubulin binding
E	0043025	cellular_component	neuronal cell body
E	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
E	0043030	biological_process	regulation of macrophage activation
E	0043065	biological_process	positive regulation of apoptotic process
E	0043066	biological_process	negative regulation of apoptotic process
E	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
E	0043524	biological_process	negative regulation of neuron apoptotic process
E	0043679	cellular_component	axon terminus
E	0045202	cellular_component	synapse
E	0045807	biological_process	positive regulation of endocytosis
E	0045920	biological_process	negative regulation of exocytosis
E	0045921	biological_process	positive regulation of exocytosis
E	0046872	molecular_function	metal ion binding
E	0046928	biological_process	regulation of neurotransmitter secretion
E	0048156	molecular_function	tau protein binding
E	0048168	biological_process	regulation of neuronal synaptic plasticity
E	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0048488	biological_process	synaptic vesicle endocytosis
E	0048489	biological_process	synaptic vesicle transport
E	0050729	biological_process	positive regulation of inflammatory response
E	0050806	biological_process	positive regulation of synaptic transmission
E	0050808	biological_process	synapse organization
E	0050812	biological_process	regulation of acyl-CoA biosynthetic process
E	0051219	molecular_function	phosphoprotein binding
E	0051259	biological_process	protein complex oligomerization
E	0051262	biological_process	protein tetramerization
E	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
E	0051402	biological_process	neuron apoptotic process
E	0051583	biological_process	dopamine uptake involved in synaptic transmission
E	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
E	0051612	biological_process	negative regulation of serotonin uptake
E	0051621	biological_process	regulation of norepinephrine uptake
E	0051622	biological_process	negative regulation of norepinephrine uptake
E	0055074	biological_process	calcium ion homeostasis
E	0060079	biological_process	excitatory postsynaptic potential
E	0060090	molecular_function	molecular adaptor activity
E	0060291	biological_process	long-term synaptic potentiation
E	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
E	0060961	molecular_function	phospholipase D inhibitor activity
E	0061024	biological_process	membrane organization
E	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
E	0070555	biological_process	response to interleukin-1
E	0070840	molecular_function	dynein complex binding
E	0071280	biological_process	cellular response to copper ion
E	0071872	biological_process	cellular response to epinephrine stimulus
E	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
E	0097435	biological_process	supramolecular fiber organization
E	0098794	cellular_component	postsynapse
E	0099512	cellular_component	supramolecular fiber
E	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
E	1903136	molecular_function	cuprous ion binding
E	1903284	biological_process	positive regulation of glutathione peroxidase activity
E	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
E	1903421	biological_process	regulation of synaptic vesicle recycling
E	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
E	1904377	biological_process	positive regulation of protein localization to cell periphery
E	1904715	biological_process	negative regulation of chaperone-mediated autophagy
E	1905606	biological_process	regulation of presynapse assembly
E	1990000	biological_process	amyloid fibril formation
E	2000377	biological_process	regulation of reactive oxygen species metabolic process
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000149	molecular_function	SNARE binding
G	0000287	molecular_function	magnesium ion binding
G	0000976	molecular_function	transcription cis-regulatory region binding
G	0001774	biological_process	microglial cell activation
G	0001921	biological_process	positive regulation of receptor recycling
G	0001956	biological_process	positive regulation of neurotransmitter secretion
G	0001963	biological_process	synaptic transmission, dopaminergic
G	0003779	molecular_function	actin binding
G	0004860	molecular_function	protein kinase inhibitor activity
G	0005504	molecular_function	fatty acid binding
G	0005507	molecular_function	copper ion binding
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005543	molecular_function	phospholipid binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005764	cellular_component	lysosome
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005886	cellular_component	plasma membrane
G	0005938	cellular_component	cell cortex
G	0006469	biological_process	negative regulation of protein kinase activity
G	0006631	biological_process	fatty acid metabolic process
G	0006638	biological_process	neutral lipid metabolic process
G	0006644	biological_process	phospholipid metabolic process
G	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
G	0007006	biological_process	mitochondrial membrane organization
G	0007268	biological_process	chemical synaptic transmission
G	0007269	biological_process	neurotransmitter secretion
G	0008198	molecular_function	ferrous iron binding
G	0008270	molecular_function	zinc ion binding
G	0008289	molecular_function	lipid binding
G	0008344	biological_process	adult locomotory behavior
G	0009410	biological_process	response to xenobiotic stimulus
G	0010040	biological_process	response to iron(II) ion
G	0010517	biological_process	regulation of phospholipase activity
G	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
G	0014048	biological_process	regulation of glutamate secretion
G	0014059	biological_process	regulation of dopamine secretion
G	0015629	cellular_component	actin cytoskeleton
G	0016020	cellular_component	membrane
G	0016079	biological_process	synaptic vesicle exocytosis
G	0016082	biological_process	synaptic vesicle priming
G	0016234	cellular_component	inclusion body
G	0016491	molecular_function	oxidoreductase activity
G	0019894	molecular_function	kinesin binding
G	0022898	biological_process	regulation of transmembrane transporter activity
G	0030424	cellular_component	axon
G	0030426	cellular_component	growth cone
G	0030544	molecular_function	Hsp70 protein binding
G	0030672	cellular_component	synaptic vesicle membrane
G	0031092	cellular_component	platelet alpha granule membrane
G	0031115	biological_process	negative regulation of microtubule polymerization
G	0031623	biological_process	receptor internalization
G	0031648	biological_process	protein destabilization
G	0032026	biological_process	response to magnesium ion
G	0032410	biological_process	negative regulation of transporter activity
G	0032496	biological_process	response to lipopolysaccharide
G	0032769	biological_process	negative regulation of monooxygenase activity
G	0032991	cellular_component	protein-containing complex
G	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
G	0034341	biological_process	response to type II interferon
G	0034599	biological_process	cellular response to oxidative stress
G	0035493	biological_process	SNARE complex assembly
G	0035543	biological_process	positive regulation of SNARE complex assembly
G	0040012	biological_process	regulation of locomotion
G	0042393	molecular_function	histone binding
G	0042416	biological_process	dopamine biosynthetic process
G	0042417	biological_process	dopamine metabolic process
G	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
G	0042802	molecular_function	identical protein binding
G	0042995	cellular_component	cell projection
G	0043014	molecular_function	alpha-tubulin binding
G	0043025	cellular_component	neuronal cell body
G	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
G	0043030	biological_process	regulation of macrophage activation
G	0043065	biological_process	positive regulation of apoptotic process
G	0043066	biological_process	negative regulation of apoptotic process
G	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
G	0043524	biological_process	negative regulation of neuron apoptotic process
G	0043679	cellular_component	axon terminus
G	0045202	cellular_component	synapse
G	0045807	biological_process	positive regulation of endocytosis
G	0045920	biological_process	negative regulation of exocytosis
G	0045921	biological_process	positive regulation of exocytosis
G	0046872	molecular_function	metal ion binding
G	0046928	biological_process	regulation of neurotransmitter secretion
G	0048156	molecular_function	tau protein binding
G	0048168	biological_process	regulation of neuronal synaptic plasticity
G	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0048488	biological_process	synaptic vesicle endocytosis
G	0048489	biological_process	synaptic vesicle transport
G	0050729	biological_process	positive regulation of inflammatory response
G	0050806	biological_process	positive regulation of synaptic transmission
G	0050808	biological_process	synapse organization
G	0050812	biological_process	regulation of acyl-CoA biosynthetic process
G	0051219	molecular_function	phosphoprotein binding
G	0051259	biological_process	protein complex oligomerization
G	0051262	biological_process	protein tetramerization
G	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
G	0051402	biological_process	neuron apoptotic process
G	0051583	biological_process	dopamine uptake involved in synaptic transmission
G	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
G	0051612	biological_process	negative regulation of serotonin uptake
G	0051621	biological_process	regulation of norepinephrine uptake
G	0051622	biological_process	negative regulation of norepinephrine uptake
G	0055074	biological_process	calcium ion homeostasis
G	0060079	biological_process	excitatory postsynaptic potential
G	0060090	molecular_function	molecular adaptor activity
G	0060291	biological_process	long-term synaptic potentiation
G	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
G	0060961	molecular_function	phospholipase D inhibitor activity
G	0061024	biological_process	membrane organization
G	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
G	0070555	biological_process	response to interleukin-1
G	0070840	molecular_function	dynein complex binding
G	0071280	biological_process	cellular response to copper ion
G	0071872	biological_process	cellular response to epinephrine stimulus
G	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
G	0097435	biological_process	supramolecular fiber organization
G	0098794	cellular_component	postsynapse
G	0099512	cellular_component	supramolecular fiber
G	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
G	1903136	molecular_function	cuprous ion binding
G	1903284	biological_process	positive regulation of glutathione peroxidase activity
G	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
G	1903421	biological_process	regulation of synaptic vesicle recycling
G	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
G	1904377	biological_process	positive regulation of protein localization to cell periphery
G	1904715	biological_process	negative regulation of chaperone-mediated autophagy
G	1905606	biological_process	regulation of presynapse assembly
G	1990000	biological_process	amyloid fibril formation
G	2000377	biological_process	regulation of reactive oxygen species metabolic process
I	0000122	biological_process	negative regulation of transcription by RNA polymerase II
I	0000149	molecular_function	SNARE binding
I	0000287	molecular_function	magnesium ion binding
I	0000976	molecular_function	transcription cis-regulatory region binding
I	0001774	biological_process	microglial cell activation
I	0001921	biological_process	positive regulation of receptor recycling
I	0001956	biological_process	positive regulation of neurotransmitter secretion
I	0001963	biological_process	synaptic transmission, dopaminergic
I	0003779	molecular_function	actin binding
I	0004860	molecular_function	protein kinase inhibitor activity
I	0005504	molecular_function	fatty acid binding
I	0005507	molecular_function	copper ion binding
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005543	molecular_function	phospholipid binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005764	cellular_component	lysosome
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005886	cellular_component	plasma membrane
I	0005938	cellular_component	cell cortex
I	0006469	biological_process	negative regulation of protein kinase activity
I	0006631	biological_process	fatty acid metabolic process
I	0006638	biological_process	neutral lipid metabolic process
I	0006644	biological_process	phospholipid metabolic process
I	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
I	0007006	biological_process	mitochondrial membrane organization
I	0007268	biological_process	chemical synaptic transmission
I	0007269	biological_process	neurotransmitter secretion
I	0008198	molecular_function	ferrous iron binding
I	0008270	molecular_function	zinc ion binding
I	0008289	molecular_function	lipid binding
I	0008344	biological_process	adult locomotory behavior
I	0009410	biological_process	response to xenobiotic stimulus
I	0010040	biological_process	response to iron(II) ion
I	0010517	biological_process	regulation of phospholipase activity
I	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
I	0014048	biological_process	regulation of glutamate secretion
I	0014059	biological_process	regulation of dopamine secretion
I	0015629	cellular_component	actin cytoskeleton
I	0016020	cellular_component	membrane
I	0016079	biological_process	synaptic vesicle exocytosis
I	0016082	biological_process	synaptic vesicle priming
I	0016234	cellular_component	inclusion body
I	0016491	molecular_function	oxidoreductase activity
I	0019894	molecular_function	kinesin binding
I	0022898	biological_process	regulation of transmembrane transporter activity
I	0030424	cellular_component	axon
I	0030426	cellular_component	growth cone
I	0030544	molecular_function	Hsp70 protein binding
I	0030672	cellular_component	synaptic vesicle membrane
I	0031092	cellular_component	platelet alpha granule membrane
I	0031115	biological_process	negative regulation of microtubule polymerization
I	0031623	biological_process	receptor internalization
I	0031648	biological_process	protein destabilization
I	0032026	biological_process	response to magnesium ion
I	0032410	biological_process	negative regulation of transporter activity
I	0032496	biological_process	response to lipopolysaccharide
I	0032769	biological_process	negative regulation of monooxygenase activity
I	0032991	cellular_component	protein-containing complex
I	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
I	0034341	biological_process	response to type II interferon
I	0034599	biological_process	cellular response to oxidative stress
I	0035493	biological_process	SNARE complex assembly
I	0035543	biological_process	positive regulation of SNARE complex assembly
I	0040012	biological_process	regulation of locomotion
I	0042393	molecular_function	histone binding
I	0042416	biological_process	dopamine biosynthetic process
I	0042417	biological_process	dopamine metabolic process
I	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
I	0042802	molecular_function	identical protein binding
I	0042995	cellular_component	cell projection
I	0043014	molecular_function	alpha-tubulin binding
I	0043025	cellular_component	neuronal cell body
I	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
I	0043030	biological_process	regulation of macrophage activation
I	0043065	biological_process	positive regulation of apoptotic process
I	0043066	biological_process	negative regulation of apoptotic process
I	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
I	0043524	biological_process	negative regulation of neuron apoptotic process
I	0043679	cellular_component	axon terminus
I	0045202	cellular_component	synapse
I	0045807	biological_process	positive regulation of endocytosis
I	0045920	biological_process	negative regulation of exocytosis
I	0045921	biological_process	positive regulation of exocytosis
I	0046872	molecular_function	metal ion binding
I	0046928	biological_process	regulation of neurotransmitter secretion
I	0048156	molecular_function	tau protein binding
I	0048168	biological_process	regulation of neuronal synaptic plasticity
I	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
I	0048471	cellular_component	perinuclear region of cytoplasm
I	0048488	biological_process	synaptic vesicle endocytosis
I	0048489	biological_process	synaptic vesicle transport
I	0050729	biological_process	positive regulation of inflammatory response
I	0050806	biological_process	positive regulation of synaptic transmission
I	0050808	biological_process	synapse organization
I	0050812	biological_process	regulation of acyl-CoA biosynthetic process
I	0051219	molecular_function	phosphoprotein binding
I	0051259	biological_process	protein complex oligomerization
I	0051262	biological_process	protein tetramerization
I	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
I	0051402	biological_process	neuron apoptotic process
I	0051583	biological_process	dopamine uptake involved in synaptic transmission
I	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
I	0051612	biological_process	negative regulation of serotonin uptake
I	0051621	biological_process	regulation of norepinephrine uptake
I	0051622	biological_process	negative regulation of norepinephrine uptake
I	0055074	biological_process	calcium ion homeostasis
I	0060079	biological_process	excitatory postsynaptic potential
I	0060090	molecular_function	molecular adaptor activity
I	0060291	biological_process	long-term synaptic potentiation
I	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
I	0060961	molecular_function	phospholipase D inhibitor activity
I	0061024	biological_process	membrane organization
I	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
I	0070555	biological_process	response to interleukin-1
I	0070840	molecular_function	dynein complex binding
I	0071280	biological_process	cellular response to copper ion
I	0071872	biological_process	cellular response to epinephrine stimulus
I	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
I	0097435	biological_process	supramolecular fiber organization
I	0098794	cellular_component	postsynapse
I	0099512	cellular_component	supramolecular fiber
I	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
I	1903136	molecular_function	cuprous ion binding
I	1903284	biological_process	positive regulation of glutathione peroxidase activity
I	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
I	1903421	biological_process	regulation of synaptic vesicle recycling
I	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
I	1904377	biological_process	positive regulation of protein localization to cell periphery
I	1904715	biological_process	negative regulation of chaperone-mediated autophagy
I	1905606	biological_process	regulation of presynapse assembly
I	1990000	biological_process	amyloid fibril formation
I	2000377	biological_process	regulation of reactive oxygen species metabolic process
L	0000122	biological_process	negative regulation of transcription by RNA polymerase II
L	0000149	molecular_function	SNARE binding
L	0000287	molecular_function	magnesium ion binding
L	0000976	molecular_function	transcription cis-regulatory region binding
L	0001774	biological_process	microglial cell activation
L	0001921	biological_process	positive regulation of receptor recycling
L	0001956	biological_process	positive regulation of neurotransmitter secretion
L	0001963	biological_process	synaptic transmission, dopaminergic
L	0003779	molecular_function	actin binding
L	0004860	molecular_function	protein kinase inhibitor activity
L	0005504	molecular_function	fatty acid binding
L	0005507	molecular_function	copper ion binding
L	0005509	molecular_function	calcium ion binding
L	0005515	molecular_function	protein binding
L	0005543	molecular_function	phospholipid binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005764	cellular_component	lysosome
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005886	cellular_component	plasma membrane
L	0005938	cellular_component	cell cortex
L	0006469	biological_process	negative regulation of protein kinase activity
L	0006631	biological_process	fatty acid metabolic process
L	0006638	biological_process	neutral lipid metabolic process
L	0006644	biological_process	phospholipid metabolic process
L	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
L	0007006	biological_process	mitochondrial membrane organization
L	0007268	biological_process	chemical synaptic transmission
L	0007269	biological_process	neurotransmitter secretion
L	0008198	molecular_function	ferrous iron binding
L	0008270	molecular_function	zinc ion binding
L	0008289	molecular_function	lipid binding
L	0008344	biological_process	adult locomotory behavior
L	0009410	biological_process	response to xenobiotic stimulus
L	0010040	biological_process	response to iron(II) ion
L	0010517	biological_process	regulation of phospholipase activity
L	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
L	0014048	biological_process	regulation of glutamate secretion
L	0014059	biological_process	regulation of dopamine secretion
L	0015629	cellular_component	actin cytoskeleton
L	0016020	cellular_component	membrane
L	0016079	biological_process	synaptic vesicle exocytosis
L	0016082	biological_process	synaptic vesicle priming
L	0016234	cellular_component	inclusion body
L	0016491	molecular_function	oxidoreductase activity
L	0019894	molecular_function	kinesin binding
L	0022898	biological_process	regulation of transmembrane transporter activity
L	0030424	cellular_component	axon
L	0030426	cellular_component	growth cone
L	0030544	molecular_function	Hsp70 protein binding
L	0030672	cellular_component	synaptic vesicle membrane
L	0031092	cellular_component	platelet alpha granule membrane
L	0031115	biological_process	negative regulation of microtubule polymerization
L	0031623	biological_process	receptor internalization
L	0031648	biological_process	protein destabilization
L	0032026	biological_process	response to magnesium ion
L	0032410	biological_process	negative regulation of transporter activity
L	0032496	biological_process	response to lipopolysaccharide
L	0032769	biological_process	negative regulation of monooxygenase activity
L	0032991	cellular_component	protein-containing complex
L	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
L	0034341	biological_process	response to type II interferon
L	0034599	biological_process	cellular response to oxidative stress
L	0035493	biological_process	SNARE complex assembly
L	0035543	biological_process	positive regulation of SNARE complex assembly
L	0040012	biological_process	regulation of locomotion
L	0042393	molecular_function	histone binding
L	0042416	biological_process	dopamine biosynthetic process
L	0042417	biological_process	dopamine metabolic process
L	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
L	0042802	molecular_function	identical protein binding
L	0042995	cellular_component	cell projection
L	0043014	molecular_function	alpha-tubulin binding
L	0043025	cellular_component	neuronal cell body
L	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
L	0043030	biological_process	regulation of macrophage activation
L	0043065	biological_process	positive regulation of apoptotic process
L	0043066	biological_process	negative regulation of apoptotic process
L	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
L	0043524	biological_process	negative regulation of neuron apoptotic process
L	0043679	cellular_component	axon terminus
L	0045202	cellular_component	synapse
L	0045807	biological_process	positive regulation of endocytosis
L	0045920	biological_process	negative regulation of exocytosis
L	0045921	biological_process	positive regulation of exocytosis
L	0046872	molecular_function	metal ion binding
L	0046928	biological_process	regulation of neurotransmitter secretion
L	0048156	molecular_function	tau protein binding
L	0048168	biological_process	regulation of neuronal synaptic plasticity
L	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0048488	biological_process	synaptic vesicle endocytosis
L	0048489	biological_process	synaptic vesicle transport
L	0050729	biological_process	positive regulation of inflammatory response
L	0050806	biological_process	positive regulation of synaptic transmission
L	0050808	biological_process	synapse organization
L	0050812	biological_process	regulation of acyl-CoA biosynthetic process
L	0051219	molecular_function	phosphoprotein binding
L	0051259	biological_process	protein complex oligomerization
L	0051262	biological_process	protein tetramerization
L	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
L	0051402	biological_process	neuron apoptotic process
L	0051583	biological_process	dopamine uptake involved in synaptic transmission
L	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
L	0051612	biological_process	negative regulation of serotonin uptake
L	0051621	biological_process	regulation of norepinephrine uptake
L	0051622	biological_process	negative regulation of norepinephrine uptake
L	0055074	biological_process	calcium ion homeostasis
L	0060079	biological_process	excitatory postsynaptic potential
L	0060090	molecular_function	molecular adaptor activity
L	0060291	biological_process	long-term synaptic potentiation
L	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
L	0060961	molecular_function	phospholipase D inhibitor activity
L	0061024	biological_process	membrane organization
L	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
L	0070555	biological_process	response to interleukin-1
L	0070840	molecular_function	dynein complex binding
L	0071280	biological_process	cellular response to copper ion
L	0071872	biological_process	cellular response to epinephrine stimulus
L	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
L	0097435	biological_process	supramolecular fiber organization
L	0098794	cellular_component	postsynapse
L	0099512	cellular_component	supramolecular fiber
L	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
L	1903136	molecular_function	cuprous ion binding
L	1903284	biological_process	positive regulation of glutathione peroxidase activity
L	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
L	1903421	biological_process	regulation of synaptic vesicle recycling
L	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
L	1904377	biological_process	positive regulation of protein localization to cell periphery
L	1904715	biological_process	negative regulation of chaperone-mediated autophagy
L	1905606	biological_process	regulation of presynapse assembly
L	1990000	biological_process	amyloid fibril formation
L	2000377	biological_process	regulation of reactive oxygen species metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
C	ASP2
E	HIS50
B	ASP2
B	HIS50
C	HIS50
G	ASP2
G	HIS50
I	ASP2
I	HIS50
L	ASP2
L	HIS50
E	ASP2

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: N-acetylmethionine => ECO:0000269|PubMed:22407793

Chain	Residue	Details
C	MET1
G	MET1
I	MET1
L	MET1
E	MET1
B	MET1

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:10617630

Chain	Residue	Details
C	SER87
G	SER87
I	SER87
L	SER87
E	SER87
B	SER87

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphotyrosine; by FYN => ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:12893833

Chain	Residue	Details
C	TYR125
G	TYR125
I	TYR125
L	TYR125
E	TYR125
B	TYR125

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphoserine; by BARK1, PLK2, CK2, CK1 and GRK5 => ECO:0000269|PubMed:10617630, ECO:0000269|PubMed:11813001, ECO:0000269|PubMed:24936070

Chain	Residue	Details
C	SER129
G	SER129
I	SER129
L	SER129
E	SER129
B	SER129

---