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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9IIO

J-shaped conformer of amyloid beta (1-40)

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	BINDING: BINDING => ECO:0000269\|PubMed:11274207, ECO:0000269\|PubMed:26898943

Chain	Residue	Details
2	HIS6
D	HIS14
E	HIS6
E	HIS14
F	HIS6
F	HIS14
G	HIS6
G	HIS14
3	HIS6
3	HIS14
H	HIS6
2	HIS14
H	HIS14
I	HIS6
I	HIS14
J	HIS6
J	HIS14
K	HIS6
K	HIS14
L	HIS6
L	HIS14
M	HIS6
A	HIS6
M	HIS14
N	HIS6
N	HIS14
4	HIS6
4	HIS14
O	HIS6
O	HIS14
P	HIS6
P	HIS14
Q	HIS6
A	HIS14
Q	HIS14
R	HIS6
R	HIS14
S	HIS6
S	HIS14
T	HIS6
T	HIS14
U	HIS6
U	HIS14
5	HIS6
B	HIS6
5	HIS14
V	HIS6
V	HIS14
W	HIS6
W	HIS14
X	HIS6
X	HIS14
Y	HIS6
Y	HIS14
Z	HIS6
B	HIS14
Z	HIS14
a	HIS6
a	HIS14
b	HIS6
b	HIS14
6	HIS6
6	HIS14
c	HIS6
c	HIS14
d	HIS6
C	HIS6
d	HIS14
e	HIS6
e	HIS14
f	HIS6
f	HIS14
g	HIS6
g	HIS14
h	HIS6
h	HIS14
i	HIS6
C	HIS14
i	HIS14
D	HIS6

site_id	SWS_FT_FI2
Number of Residues	40
Details	BINDING: BINDING => ECO:0000305\|PubMed:10413512, ECO:0000305\|PubMed:11274207

Chain	Residue	Details
2	TYR10
H	TYR10
I	TYR10
J	TYR10
K	TYR10
L	TYR10
M	TYR10
N	TYR10
4	TYR10
O	TYR10
P	TYR10
A	TYR10
Q	TYR10
R	TYR10
S	TYR10
T	TYR10
U	TYR10
5	TYR10
V	TYR10
W	TYR10
X	TYR10
Y	TYR10
B	TYR10
Z	TYR10
a	TYR10
b	TYR10
6	TYR10
c	TYR10
d	TYR10
e	TYR10
f	TYR10
g	TYR10
h	TYR10
C	TYR10
i	TYR10
D	TYR10
E	TYR10
F	TYR10
G	TYR10
3	TYR10

site_id	SWS_FT_FI3
Number of Residues	40
Details	BINDING: BINDING => ECO:0000269\|PubMed:10413512, ECO:0000269\|PubMed:11274207, ECO:0000269\|PubMed:26898943

Chain	Residue	Details
2	HIS13
H	HIS13
I	HIS13
J	HIS13
K	HIS13
L	HIS13
M	HIS13
N	HIS13
4	HIS13
O	HIS13
P	HIS13
A	HIS13
Q	HIS13
R	HIS13
S	HIS13
T	HIS13
U	HIS13
5	HIS13
V	HIS13
W	HIS13
X	HIS13
Y	HIS13
B	HIS13
Z	HIS13
a	HIS13
b	HIS13
6	HIS13
c	HIS13
d	HIS13
e	HIS13
f	HIS13
g	HIS13
h	HIS13
C	HIS13
i	HIS13
D	HIS13
E	HIS13
F	HIS13
G	HIS13
3	HIS13

site_id	SWS_FT_FI4
Number of Residues	40
Details	SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671

Chain	Residue	Details
2	ASP1
H	ASP1
I	ASP1
J	ASP1
K	ASP1
L	ASP1
M	ASP1
N	ASP1
4	ASP1
O	ASP1
P	ASP1
A	ASP1
Q	ASP1
R	ASP1
S	ASP1
T	ASP1
U	ASP1
5	ASP1
V	ASP1
W	ASP1
X	ASP1
Y	ASP1
B	ASP1
Z	ASP1
a	ASP1
b	ASP1
6	ASP1
c	ASP1
d	ASP1
e	ASP1
f	ASP1
g	ASP1
h	ASP1
C	ASP1
i	ASP1
D	ASP1
E	ASP1
F	ASP1
G	ASP1
3	ASP1

site_id	SWS_FT_FI5
Number of Residues	40
Details	SITE: Cleavage; by ACE => ECO:0000269\|PubMed:11604391, ECO:0000269\|PubMed:16154999

Chain	Residue	Details
2	ASP7
H	ASP7
I	ASP7
J	ASP7
K	ASP7
L	ASP7
M	ASP7
N	ASP7
4	ASP7
O	ASP7
P	ASP7
A	ASP7
Q	ASP7
R	ASP7
S	ASP7
T	ASP7
U	ASP7
5	ASP7
V	ASP7
W	ASP7
X	ASP7
Y	ASP7
B	ASP7
Z	ASP7
a	ASP7
b	ASP7
6	ASP7
c	ASP7
d	ASP7
e	ASP7
f	ASP7
g	ASP7
h	ASP7
C	ASP7
i	ASP7
D	ASP7
E	ASP7
F	ASP7
G	ASP7
3	ASP7

site_id	SWS_FT_FI6
Number of Residues	40
Details	SITE: Cleavage; by alpha-secretase => ECO:0000305\|PubMed:11851430

Chain	Residue	Details
2	LYS16
H	LYS16
I	LYS16
J	LYS16
K	LYS16
L	LYS16
M	LYS16
N	LYS16
4	LYS16
O	LYS16
P	LYS16
A	LYS16
Q	LYS16
R	LYS16
S	LYS16
T	LYS16
U	LYS16
5	LYS16
V	LYS16
W	LYS16
X	LYS16
Y	LYS16
B	LYS16
Z	LYS16
a	LYS16
b	LYS16
6	LYS16
c	LYS16
d	LYS16
e	LYS16
f	LYS16
g	LYS16
h	LYS16
C	LYS16
i	LYS16
D	LYS16
E	LYS16
F	LYS16
G	LYS16
3	LYS16

site_id	SWS_FT_FI7
Number of Residues	40
Details	SITE: Cleavage; by theta-secretase => ECO:0000269\|PubMed:16816112

Chain	Residue	Details
2	PHE19
H	PHE19
I	PHE19
J	PHE19
K	PHE19
L	PHE19
M	PHE19
N	PHE19
4	PHE19
O	PHE19
P	PHE19
A	PHE19
Q	PHE19
R	PHE19
S	PHE19
T	PHE19
U	PHE19
5	PHE19
V	PHE19
W	PHE19
X	PHE19
Y	PHE19
B	PHE19
Z	PHE19
a	PHE19
b	PHE19
6	PHE19
c	PHE19
d	PHE19
e	PHE19
f	PHE19
g	PHE19
h	PHE19
C	PHE19
i	PHE19
D	PHE19
E	PHE19
F	PHE19
G	PHE19
3	PHE19

site_id	SWS_FT_FI8
Number of Residues	40
Details	SITE: Implicated in free radical propagation => ECO:0000250

Chain	Residue	Details
2	GLY33
H	GLY33
I	GLY33
J	GLY33
K	GLY33
L	GLY33
M	GLY33
N	GLY33
4	GLY33
O	GLY33
P	GLY33
A	GLY33
Q	GLY33
R	GLY33
S	GLY33
T	GLY33
U	GLY33
5	GLY33
V	GLY33
W	GLY33
X	GLY33
Y	GLY33
B	GLY33
Z	GLY33
a	GLY33
b	GLY33
6	GLY33
c	GLY33
d	GLY33
e	GLY33
f	GLY33
g	GLY33
h	GLY33
C	GLY33
i	GLY33
D	GLY33
E	GLY33
F	GLY33
G	GLY33
3	GLY33

site_id	SWS_FT_FI9
Number of Residues	40
Details	SITE: Susceptible to oxidation => ECO:0000269\|PubMed:10535332

Chain	Residue	Details
2	MET35
H	MET35
I	MET35
J	MET35
K	MET35
L	MET35
M	MET35
N	MET35
4	MET35
O	MET35
P	MET35
A	MET35
Q	MET35
R	MET35
S	MET35
T	MET35
U	MET35
5	MET35
V	MET35
W	MET35
X	MET35
Y	MET35
B	MET35
Z	MET35
a	MET35
b	MET35
6	MET35
c	MET35
d	MET35
e	MET35
f	MET35
g	MET35
h	MET35
C	MET35
i	MET35
D	MET35
E	MET35
F	MET35
G	MET35
3	MET35

site_id	SWS_FT_FI10
Number of Residues	40
Details	SITE: Cleavage; by gamma-secretase; site 1 => ECO:0000305\|PubMed:11851430

Chain	Residue	Details
2	VAL40
H	VAL40
I	VAL40
J	VAL40
K	VAL40
L	VAL40
M	VAL40
N	VAL40
4	VAL40
O	VAL40
P	VAL40
A	VAL40
Q	VAL40
R	VAL40
S	VAL40
T	VAL40
U	VAL40
5	VAL40
V	VAL40
W	VAL40
X	VAL40
Y	VAL40
B	VAL40
Z	VAL40
a	VAL40
b	VAL40
6	VAL40
c	VAL40
d	VAL40
e	VAL40
f	VAL40
g	VAL40
h	VAL40
C	VAL40
i	VAL40
D	VAL40
E	VAL40
F	VAL40
G	VAL40
3	VAL40

site_id	SWS_FT_FI11
Number of Residues	40
Details	CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269\|PubMed:22576872

Chain	Residue	Details
2	TYR10
H	TYR10
I	TYR10
J	TYR10
K	TYR10
L	TYR10
M	TYR10
N	TYR10
4	TYR10
O	TYR10
P	TYR10
A	TYR10
Q	TYR10
R	TYR10
S	TYR10
T	TYR10
U	TYR10
5	TYR10
V	TYR10
W	TYR10
X	TYR10
Y	TYR10
B	TYR10
Z	TYR10
a	TYR10
b	TYR10
6	TYR10
c	TYR10
d	TYR10
e	TYR10
f	TYR10
g	TYR10
h	TYR10
C	TYR10
i	TYR10
D	TYR10
E	TYR10
F	TYR10
G	TYR10
3	TYR10

235458

PDB entries from 2025-04-30

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