Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9IHR

Closed state with NUQM and with flavoprotein (classification state 1) of Pichia pastoris mitochondrial complex I in cMSP26 nanodiscs

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0005739	cellular_component	mitochondrion
1	0016884	molecular_function	carbon-nitrogen ligase activity, with glutamine as amido-N-donor
a	0005743	cellular_component	mitochondrial inner membrane
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0016020	cellular_component	membrane
A	0030964	cellular_component	NADH dehydrogenase complex
A	0031966	cellular_component	mitochondrial membrane
A	1902600	biological_process	proton transmembrane transport
B	0005739	cellular_component	mitochondrion
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0009060	biological_process	aerobic respiration
B	0015990	biological_process	electron transport coupled proton transport
B	0032981	biological_process	mitochondrial respiratory chain complex I assembly
B	0045271	cellular_component	respiratory chain complex I
B	0048038	molecular_function	quinone binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	0005739	cellular_component	mitochondrion
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0016020	cellular_component	membrane
C	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
C	1902600	biological_process	proton transmembrane transport
D	0005739	cellular_component	mitochondrion
D	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
D	0048038	molecular_function	quinone binding
D	0051287	molecular_function	NAD binding
E	0005743	cellular_component	mitochondrial inner membrane
E	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
E	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
E	0016491	molecular_function	oxidoreductase activity
E	0045271	cellular_component	respiratory chain complex I
E	1902600	biological_process	proton transmembrane transport
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
F	0010181	molecular_function	FMN binding
F	0045271	cellular_component	respiratory chain complex I
F	0051287	molecular_function	NAD binding
F	0051539	molecular_function	4 iron, 4 sulfur cluster binding
F	1902600	biological_process	proton transmembrane transport
G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
G	0042773	biological_process	ATP synthesis coupled electron transport
G	0051536	molecular_function	iron-sulfur cluster binding
G	1902600	biological_process	proton transmembrane transport
H	0003954	molecular_function	NADH dehydrogenase activity
H	0005743	cellular_component	mitochondrial inner membrane
H	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
H	0009060	biological_process	aerobic respiration
H	0016020	cellular_component	membrane
H	1902600	biological_process	proton transmembrane transport
I	0003954	molecular_function	NADH dehydrogenase activity
I	0005739	cellular_component	mitochondrion
I	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
I	0009060	biological_process	aerobic respiration
I	0016020	cellular_component	membrane
I	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
I	0032981	biological_process	mitochondrial respiratory chain complex I assembly
I	0051539	molecular_function	4 iron, 4 sulfur cluster binding
j	0005743	cellular_component	mitochondrial inner membrane
j	0045271	cellular_component	respiratory chain complex I
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0031966	cellular_component	mitochondrial membrane
J	1902600	biological_process	proton transmembrane transport
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0022900	biological_process	electron transport chain
k	0032981	biological_process	mitochondrial respiratory chain complex I assembly
k	0045271	cellular_component	respiratory chain complex I
l	0005739	cellular_component	mitochondrion
L	0003954	molecular_function	NADH dehydrogenase activity
L	0005743	cellular_component	mitochondrial inner membrane
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0015990	biological_process	electron transport coupled proton transport
L	0042773	biological_process	ATP synthesis coupled electron transport
M	0003954	molecular_function	NADH dehydrogenase activity
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0009060	biological_process	aerobic respiration
M	0015990	biological_process	electron transport coupled proton transport
M	0016020	cellular_component	membrane
M	0031966	cellular_component	mitochondrial membrane
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0048039	molecular_function	ubiquinone binding
n	0005743	cellular_component	mitochondrial inner membrane
n	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0016020	cellular_component	membrane
N	1902600	biological_process	proton transmembrane transport
o	0005739	cellular_component	mitochondrion
o	0005743	cellular_component	mitochondrial inner membrane
o	0005758	cellular_component	mitochondrial intermembrane space
p	0005743	cellular_component	mitochondrial inner membrane
P	0005739	cellular_component	mitochondrion
P	0044877	molecular_function	protein-containing complex binding
q	0005743	cellular_component	mitochondrial inner membrane
q	0006979	biological_process	response to oxidative stress
q	0016020	cellular_component	membrane
q	0045271	cellular_component	respiratory chain complex I
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0016020	cellular_component	membrane
Q	0022900	biological_process	electron transport chain
R	0005739	cellular_component	mitochondrion
R	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S	0005743	cellular_component	mitochondrial inner membrane
T	0000035	molecular_function	acyl binding
T	0000036	molecular_function	acyl carrier activity
T	0005739	cellular_component	mitochondrion
T	0006633	biological_process	fatty acid biosynthetic process
T	1902494	cellular_component	catalytic complex
U	0000035	molecular_function	acyl binding
U	0000036	molecular_function	acyl carrier activity
U	0005739	cellular_component	mitochondrion
U	0006633	biological_process	fatty acid biosynthetic process
U	0099128	cellular_component	mitochondrial [2Fe-2S] assembly complex
V	0005743	cellular_component	mitochondrial inner membrane
V	0022904	biological_process	respiratory electron transport chain
W	0005743	cellular_component	mitochondrial inner membrane
W	0006979	biological_process	response to oxidative stress
W	0045271	cellular_component	respiratory chain complex I
X	0005743	cellular_component	mitochondrial inner membrane
X	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Z	0005739	cellular_component	mitochondrion
Z	0005743	cellular_component	mitochondrial inner membrane
Z	0016020	cellular_component	membrane
Z	0045271	cellular_component	respiratory chain complex I

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGMDSLDLNDALVAL

Chain	Residue	Details
T	ASP81-LEU96

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP

Chain	Residue	Details
I	CYS123-PRO134
I	CYS162-PRO173

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEsK

Chain	Residue	Details
D	LEU135-LYS146

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREtyDLFgiffegHpdlRrIM

Chain	Residue	Details
C	GLU185-MET206

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PryCYheklavaGnCRmC

Chain	Residue	Details
G	PRO56-CYS73

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPvCDqGGeCdLQ

Chain	Residue	Details
G	CYS123-GLN135

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIhCtRCVrF

Chain	Residue	Details
G	ARG172-PHE182

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GMGAYICGEETALIES

Chain	Residue	Details
F	GLY184-SER199

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
F	GLU361-GLY372

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GVLMaVaDALKLLsKE

Chain	Residue	Details
H	GLY56-GLU71

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDNVEAEseLVs.G

Chain	Residue	Details
H	PRO211-GLY224

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DnlFTlqeveCLGaCvnAP

Chain	Residue	Details
E	ASP158-PRO176

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GvDRIVPVDIYvPgCPP

Chain	Residue	Details
B	GLY159-PRO175

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)