9IEX

Human Deoxyhypusine Synthase Fragment Screening Campaign - VT0155 follow-up ligand DMP7

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0008216	biological_process	spermidine metabolic process
A	0008284	biological_process	positive regulation of cell population proliferation
A	0034038	molecular_function	deoxyhypusine synthase activity
A	0042802	molecular_function	identical protein binding
A	0046203	biological_process	spermidine catabolic process
A	0051604	biological_process	protein maturation
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006412	biological_process	translation
B	0008216	biological_process	spermidine metabolic process
B	0008284	biological_process	positive regulation of cell population proliferation
B	0034038	molecular_function	deoxyhypusine synthase activity
B	0042802	molecular_function	identical protein binding
B	0046203	biological_process	spermidine catabolic process
B	0051604	biological_process	protein maturation
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006412	biological_process	translation
C	0008216	biological_process	spermidine metabolic process
C	0008284	biological_process	positive regulation of cell population proliferation
C	0034038	molecular_function	deoxyhypusine synthase activity
C	0042802	molecular_function	identical protein binding
C	0046203	biological_process	spermidine catabolic process
C	0051604	biological_process	protein maturation
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006412	biological_process	translation
D	0008216	biological_process	spermidine metabolic process
D	0008284	biological_process	positive regulation of cell population proliferation
D	0034038	molecular_function	deoxyhypusine synthase activity
D	0042802	molecular_function	identical protein binding
D	0046203	biological_process	spermidine catabolic process
D	0051604	biological_process	protein maturation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"9405486","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9493264","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	40
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 687

Chain	Residue	Details
B	GLU137	electrostatic stabiliser
B	VAL337	covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor

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site_id	MCSA2
Number of Residues	2
Details	M-CSA 687

Chain	Residue	Details
D	GLU137	electrostatic stabiliser
D	VAL337	covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor

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