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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9I9K

Cryo-EM structure of CAK-CDK2 (determined in the presence of ADP-AlFx)

Functional Information from GO Data
ChainGOidnamespacecontents
H0000082biological_processG1/S transition of mitotic cell cycle
H0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
H0000439cellular_componenttranscription factor TFIIH core complex
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005675cellular_componenttranscription factor TFIIH holo complex
H0006281biological_processDNA repair
H0006289biological_processnucleotide-excision repair
H0006357biological_processregulation of transcription by RNA polymerase II
H0006367biological_processtranscription initiation at RNA polymerase II promoter
H0008270molecular_functionzinc ion binding
H0030674molecular_functionprotein-macromolecule adaptor activity
H0043066biological_processnegative regulation of apoptotic process
H0045737biological_processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
H0048661biological_processpositive regulation of smooth muscle cell proliferation
H0061575molecular_functioncyclin-dependent protein serine/threonine kinase activator activity
H0070516cellular_componentCAK-ERCC2 complex
H0070985cellular_componenttranscription factor TFIIK complex
H2000045biological_processregulation of G1/S transition of mitotic cell cycle
I0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
I0000439cellular_componenttranscription factor TFIIH core complex
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005675cellular_componenttranscription factor TFIIH holo complex
I0006289biological_processnucleotide-excision repair
I0006351biological_processDNA-templated transcription
I0006357biological_processregulation of transcription by RNA polymerase II
I0006367biological_processtranscription initiation at RNA polymerase II promoter
I0016251molecular_functionRNA polymerase II general transcription initiation factor activity
I0016301molecular_functionkinase activity
I0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
I0050821biological_processprotein stabilization
I0070516cellular_componentCAK-ERCC2 complex
I0070985cellular_componenttranscription factor TFIIK complex
I2000045biological_processregulation of G1/S transition of mitotic cell cycle
J0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
J0000439cellular_componenttranscription factor TFIIH core complex
J0001650cellular_componentfibrillar center
J0004672molecular_functionprotein kinase activity
J0004674molecular_functionprotein serine/threonine kinase activity
J0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
J0005515molecular_functionprotein binding
J0005524molecular_functionATP binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005675cellular_componenttranscription factor TFIIH holo complex
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0006289biological_processnucleotide-excision repair
J0006366biological_processtranscription by RNA polymerase II
J0006367biological_processtranscription initiation at RNA polymerase II promoter
J0006468biological_processprotein phosphorylation
J0008094molecular_functionATP-dependent activity, acting on DNA
J0008353molecular_functionRNA polymerase II CTD heptapeptide repeat kinase activity
J0016301molecular_functionkinase activity
J0042795biological_processsnRNA transcription by RNA polymerase II
J0045944biological_processpositive regulation of transcription by RNA polymerase II
J0048471cellular_componentperinuclear region of cytoplasm
J0050821biological_processprotein stabilization
J0051726biological_processregulation of cell cycle
J0070516cellular_componentCAK-ERCC2 complex
J0070985cellular_componenttranscription factor TFIIK complex
J0106310molecular_functionprotein serine kinase activity
J0140836molecular_functionRNA polymerase II CTD heptapeptide repeat S5 kinase activity
J2000045biological_processregulation of G1/S transition of mitotic cell cycle
K0000082biological_processG1/S transition of mitotic cell cycle
K0000086biological_processG2/M transition of mitotic cell cycle
K0000287molecular_functionmagnesium ion binding
K0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
K0000781cellular_componentchromosome, telomeric region
K0000793cellular_componentcondensed chromosome
K0000805cellular_componentX chromosome
K0000806cellular_componentY chromosome
K0004672molecular_functionprotein kinase activity
K0004674molecular_functionprotein serine/threonine kinase activity
K0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
K0005515molecular_functionprotein binding
K0005524molecular_functionATP binding
K0005634cellular_componentnucleus
K0005635cellular_componentnuclear envelope
K0005654cellular_componentnucleoplasm
K0005667cellular_componenttranscription regulator complex
K0005737cellular_componentcytoplasm
K0005768cellular_componentendosome
K0005813cellular_componentcentrosome
K0005829cellular_componentcytosol
K0006260biological_processDNA replication
K0006338biological_processchromatin remodeling
K0006468biological_processprotein phosphorylation
K0007099biological_processcentriole replication
K0007165biological_processsignal transduction
K0007265biological_processRas protein signal transduction
K0007346biological_processregulation of mitotic cell cycle
K0008284biological_processpositive regulation of cell population proliferation
K0015030cellular_componentCajal body
K0016301molecular_functionkinase activity
K0018105biological_processpeptidyl-serine phosphorylation
K0019904molecular_functionprotein domain specific binding
K0030332molecular_functioncyclin binding
K0031453biological_processpositive regulation of heterochromatin formation
K0031571biological_processmitotic G1 DNA damage checkpoint signaling
K0035173molecular_functionhistone kinase activity
K0036064cellular_componentciliary basal body
K0043247biological_processtelomere maintenance in response to DNA damage
K0043687biological_processpost-translational protein modification
K0045740biological_processpositive regulation of DNA replication
K0051298biological_processcentrosome duplication
K0051321biological_processmeiotic cell cycle
K0071732biological_processcellular response to nitric oxide
K0090398biological_processcellular senescence
K0097123cellular_componentcyclin A1-CDK2 complex
K0097124cellular_componentcyclin A2-CDK2 complex
K0097134cellular_componentcyclin E1-CDK2 complex
K0097135cellular_componentcyclin E2-CDK2 complex
K0097472molecular_functioncyclin-dependent protein kinase activity
K0106310molecular_functionprotein serine kinase activity
K0120186biological_processnegative regulation of protein localization to chromatin
K0120261biological_processregulation of heterochromatin organization
K1905784biological_processregulation of anaphase-promoting complex-dependent catabolic process
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGVVYkArnkltgev..........VALK
ChainResidueDetails
KILE10-LYS33
JLEU18-LYS42
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI
ChainResidueDetails
KVAL123-ILE135
JILE133-LEU145
site_idPS00518
Number of Residues10
DetailsZF_RING_1 Zinc finger RING-type signature. CgHtLCesCV
ChainResidueDetails
HCYS26-VAL35
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by CDK8","evidences":[{"source":"PubMed","id":"10993082","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues283
DetailsDomain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15530371","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15530371","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"41100585","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9I9J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"41100585","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9I9I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9I9K","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"41100585","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9I9J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9I9K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9QCV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9SKQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by CDK1 and CDK2","evidences":[{"source":"PubMed","id":"11113184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9832506","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by CDK2","evidences":[{"source":"PubMed","id":"11113184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15530371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9832506","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsActive site: {"description":"Proton acceptor"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17095507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21565702","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"41100585","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9I9J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9I9K","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"41100585","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9I9K","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21565702","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21565702","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41100585","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9I9K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9QCV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues3
DetailsSite: {"description":"CDK7 binding","evidences":[{"source":"PubMed","id":"17373709","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"1396589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17095507","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by WEE1","evidences":[{"source":"PubMed","id":"1396589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17095507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by CAK and CCRK","evidences":[{"source":"PubMed","id":"1396589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14597612","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16325401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17095507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17570665","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20147522","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360007","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21565702","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41100585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28666995","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

256448

PDB entries from 2026-07-15

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